Lactose (CID 6134) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(1)
 
 
Unspecified(30)
 
 
Top Targets:
GLECT(5)
 
 
lectin legume..(2)
 
 
GH7 CBH EG(1)
 
 
Glyco transf..(1)
 
 
BioAssay Types:
Literature(41)
 
 
 
 
BioActivity Types:
Kd(8)
 
 
 
IC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 41    Data Row: 44   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234182]
Kd 23Binding affinity to galectin 9N terminal domain at 0 degC by fluorescence polarization assay [AID412879, Type: Literature]
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2
[SID104234182]
IC50 45Inhibitory concentration against Escherichia coli heat-labile enterotoxin (LT) binding to ganglioside GD1b was determined by ELISA assay [AID71736, Type: Literature]
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3
[SID48416152]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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4
[SID104234182]
 Reduction of CD45 co-localization with GM1-enriched microdomain in human Jurkat T cells after 3 days [AID381563, Type: Literature]
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5
[SID104234182]
 Induction of Nck protein binding to TCR complex in human Jurkat T cells by immunoprecipitation [AID381590, Type: Literature]
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6
[SID104234182]
 Inhibition of galectin-8 binding to biotinylated lectin at cell surface of human SW480 cells at 2 mM by fluorometric analysis [AID613017, Type: Literature]
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7
[SID104234182]
 Inhibition of galectin-9 binding to biotinylated lectin at cell surface of human SW480 cells at 2 mM by fluorometric analysis [AID613018, Type: Literature]
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8
[SID104234182]
 Inhibition of galectin-3 binding to biotinylated lectin at cell surface of human Jurkat T-cells at 100 uM by fluorometric analysis [AID613024, Type: Literature]
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9
[SID104234182]
 Inhibition of galectin-3 binding to biotinylated lectin at cell surface of human SW480 cells at 100 uM by fluorometric analysis [AID613025, Type: Literature]
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10
[SID46392060]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, High-Resolution Crystal Structure Of Erythrina Cristagalli Lectin In Complex With Lactose [gi:21730304]
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11
[SID46392050]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Alpha-,1,3 Galactosyltransferase - Lactose Complex [gi:29726233]
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12
[SID46393700]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Phanerochaete Chrysosporium Cellobiohydrolase Cel7d (Cbh58) In Complex With La [gi:66361309]
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13
[SID46391476]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Erythrina Corallodendron Lectin In Complex With Lactose [gi:157830124]
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14
[SID104234182]
Kd 62Binding affinity to galectin 8N terminal domain at 20 degC by fluorescence polarization assay [AID412878, Type: Literature]
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15
[SID104234182]
Kd 81Affinity towards Cholera toxin B5 pentamer [AID51624, Type: Literature]
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16
[SID104234182]
Kd 110Binding affinity to galectin 3 at 20 degC by fluorescence polarization assay [AID412876, Type: Literature]
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17
[SID104234182]
Kd 110Binding affinity to galectin 7 at 0 degC by fluorescence polarization assay [AID412884, Type: Literature]
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18
[SID104234182]
Kd 220Dissociation constant against galectin-3 using competitive fluorescence polarization [AID238137, Type: Literature]
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19
[SID104234182]
Kd 222Dissociation constant for mouse Galectin-3 [AID238126, Type: Literature]
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20
[SID104234182]
Kd 420Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay [AID412875, Type: Literature]
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21
[SID104234182]
IC50 800Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay [AID362218, Type: Literature]
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22
[SID104234182]
IC50 800Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutination assay [AID362219, Type: Literature]
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23
[SID104234182]
MIC 1250Minimum inhibitory concentration required for in vitro inhibition of flocculation against cell wall galactose-specific yeast lectin (KbCWL) [AID220224, Type: other]
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24
[SID104234182]
Km 40000Activity at Neisseria meningitidis lgtC by UV-VIS spectroscopy [AID500278, Type: Literature]
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25
[SID104234182]
 Acceptor substrate specificity toward Fucosyltransferase for the galactosides of GlcNAc with beta 1,3 or beta 1,4-linkages [AID71968, Type: other]
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26
[SID104234182]
 Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay relative to galactose [AID362220, Type: Literature]
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27
[SID104234182]
 Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutination assay relative to galactose [AID362221, Type: Literature]
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28
[SID104234182]
 Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 5 mM [AID305311, Type: Literature]
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29
[SID104234182]
 Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 2mM [AID305312, Type: Literature]
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30
[SID104234182]
 Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 0.5mM [AID305313, Type: Literature]
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31
[SID104234182]
 Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 1mM [AID305309, Type: Literature]
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32
[SID104234182]
 Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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33
[SID104234182]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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34
[SID104234182]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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35
[SID104234182]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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36
[SID104234182]
 Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
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37
[SID104234182]
 Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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38
[SID104234182]
 Ratio of Kcat to Km for Neisseria meningitidis lgtC [AID500279, Type: Literature]
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39
[SID104234182]
 Inhibition of carbohydrate-dependent human galectin1 binding at 10 mM by solid phase assay [AID305307, Type: Literature]Galectin-1 [gi:126155]
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40
[SID104234182]
 Inhibition of Galectin1 [AID261924, Type: Literature]Galectin-1 [gi:126155]
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41
[SID104234182]
 Inhibition of Galectin3 [AID261925, Type: Literature]Galectin-3 [gi:215274262]
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42
[SID104234182]
 Inhibition of carbohydrate-dependent human galectin3 binding at 10 mM by solid phase assay [AID305308, Type: Literature]Galectin-3 [gi:215274262]
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43
[SID104234182]
 Relative affinity for mouse Galectin-3 compared to D-galactose-methyl-beta-glycoside [AID251085, Type: Literature]Galectin-3 [gi:126679]
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44
[SID104234182]
 Inhibition of galectin-3 binding to biotinylated lectin at cell surface of human Jurkat T-cells at 2 mM by fluorometric analysis [AID613015, Type: Literature]
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