Bookmark and Share
Lactose (CID 6134) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(82)
 
 
Inconclusive(5)
 
 
Unspecified(44)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
GLECT(6)
 
 
NR LBD Fxr(4)
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
Literature(55)
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(80)
 
 
 
IC50(13)
 
 
 
Kd(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 141    Data Row: 144   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234182]
Kd 23Binding affinity to galectin 9N terminal domain at 0 degC by fluorescence polarization assay [AID412879, Type: Literature]
View
2
[SID104234182]
IC50 45Inhibitory concentration against Escherichia coli heat-labile enterotoxin (LT) binding to ganglioside GD1b was determined by ELISA assay [AID71736, Type: Literature]
View
3
[SID48416152]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
4
[SID104234182]
Inhibition of galectin-8 binding to biotinylated lectin at cell surface of human SW480 cells at 2 mM by fluorometric analysis [AID613017, Type: Literature]
View
5
[SID104234182]
Inhibition of galectin-9 binding to biotinylated lectin at cell surface of human SW480 cells at 2 mM by fluorometric analysis [AID613018, Type: Literature]
View
6
[SID104234182]
Inhibition of galectin-3 binding to biotinylated lectin at cell surface of human Jurkat T-cells at 100 uM by fluorometric analysis [AID613024, Type: Literature]
View
7
[SID104234182]
Inhibition of galectin-3 binding to biotinylated lectin at cell surface of human SW480 cells at 100 uM by fluorometric analysis [AID613025, Type: Literature]
View
8
[SID104234182]
Reduction of CD45 co-localization with GM1-enriched microdomain in human Jurkat T cells after 3 days [AID381563, Type: Literature]
View
9
[SID104234182]
Induction of Nck protein binding to TCR complex in human Jurkat T cells by immunoprecipitation [AID381590, Type: Literature]
View
10
[SID46392060]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, High-Resolution Crystal Structure Of Erythrina Cristagalli Lectin In Complex With Lactose [gi:21730304]
View
11
[SID46392050]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Alpha-,1,3 Galactosyltransferase - Lactose Complex [gi:29726233]
View
12
[SID46393700]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Phanerochaete Chrysosporium Cellobiohydrolase Cel7d (Cbh58) In Complex With Lactose [gi:66361309]
View
13
[SID46391476]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Erythrina Corallodendron Lectin In Complex With Lactose [gi:157830124]
View
14
[SID104234182]
Kd 62Binding affinity to galectin 8N terminal domain at 20 degC by fluorescence polarization assay [AID412878, Type: Literature]
View
15
[SID104234182]
Kd 81Affinity towards Cholera toxin B5 pentamer [AID51624, Type: Literature]
View
16
[SID104234182]
Kd 110Binding affinity to galectin 3 at 20 degC by fluorescence polarization assay [AID412876, Type: Literature]
View
17
[SID104234182]
Kd 110Binding affinity to galectin 7 at 0 degC by fluorescence polarization assay [AID412884, Type: Literature]
View
18
[SID104234182]
Kd 220Dissociation constant against galectin-3 using competitive fluorescence polarization [AID238137, Type: Literature]
View
19
[SID104234182]
Kd 222Dissociation constant for mouse Galectin-3 [AID238126, Type: Literature]
View
20
[SID104234182]
Kd 420Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay [AID412875, Type: Literature]
View
21
[SID104234182]
IC50 500Inhibition of binding of biotinylated chicken galectin-1A to surface immobilized asialofetuin by solid phase assay [AID716905, Type: Literature]
View
22
[SID104234182]
IC50 600Inhibition of binding of biotinylated Viscum album agglutinin to surface immobilized asialofetuin by solid phase assay [AID716902, Type: Literature]
View
23
[SID104234182]
IC50 800Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay [AID362218, Type: Literature]
View
24
[SID104234182]
IC50 800Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutination assay [AID362219, Type: Literature]
View
25
[SID104234182]
IC50 1100Inhibition of binding of biotinylated chicken galectin-3 to surface immobilized asialofetuin by solid phase assay [AID716895, Type: Literature]
View
26
[SID104234182]
IC50 1100Inhibition of binding of biotinylated Erythrina crista-galli agglutinin to surface immobilized asialofetuin by solid phase assay [AID716900, Type: Literature]
View
27
[SID104234182]
MIC 1250Minimum inhibitory concentration required for in vitro inhibition of flocculation against cell wall galactose-specific yeast lectin (KbCWL) [AID220224, Type: other]
View
28
[SID104234182]
IC50 1600Inhibition of binding of biotinylated chicken galectin-8N to surface immobilized asialofetuin by solid phase assay [AID716887, Type: Literature]
View
29
[SID104234182]
IC50 1800Inhibition of binding of biotinylated chicken galectin-8S to surface immobilized asialofetuin by solid phase assay [AID716891, Type: Literature]
View
30
[SID104234182]
IC50 4000Inhibition of binding of biotinylated chicken galectin-1B to surface immobilized asialofetuin by solid phase assay [AID716898, Type: Literature]Beta-galactoside-binding lectin [gi:126163]
View
31
[SID104234182]
IC50 4500Inhibition of binding of biotinylated truncated chicken galectin-3 to surface immobilized asialofetuin by solid phase assay [AID716893, Type: Literature]
View
32
[SID104234182]
IC50 5000Inhibition of binding of biotinylated chicken galectin-8L to surface immobilized asialofetuin by solid phase assay [AID716889, Type: Literature]
View
33
[SID104234182]
IC50 6000Inhibition of binding of biotinylated chicken galectin-2 to surface immobilized asialofetuin by solid phase assay [AID716897, Type: Literature]
View
34
[SID104234182]
Km 40000Activity at Neisseria meningitidis lgtC by UV-VIS spectroscopy [AID500278, Type: Literature]
View
35
[SID104234182]
Ratio of Kcat to Km for Neisseria meningitidis lgtC [AID500279, Type: Literature]
View
36
[SID104234182]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
View
37
[SID104234182]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
View
38
[SID104234182]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
View
39
[SID104234182]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
View
40
[SID104234182]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
View
41
[SID104234182]
Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay relative to galactose [AID362220, Type: Literature]
View
42
[SID104234182]
Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutination assay relative to galactose [AID362221, Type: Literature]
View
43
[SID104234182]
Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 1mM [AID305309, Type: Literature]
View
44
[SID104234182]
Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 5 mM [AID305311, Type: Literature]
View
45
[SID104234182]
Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 2mM [AID305312, Type: Literature]
View
46
[SID104234182]
Inhibition of carbohydrate-dependent galectin3 binding to human SW480 cell surface at 0.5mM [AID305313, Type: Literature]
View
47
[SID104234182]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
View
48
[SID104234182]
Inhibition of binding of biotinylated chicken galectin-8S to CHO cells at 1 mM by cytofluorometry [AID716881, Type: Literature]
View
49
[SID104234182]
Inhibition of binding of biotinylated Erythrina crista-galli agglutinin to SW480 cells at 0.2 mM by cytofluorometry [AID716882, Type: Literature]
View
50
[SID104234182]
Inhibition of binding of biotinylated truncated chicken galectin-3 to CHO cells at 2 mM by cytofluorometry [AID716883, Type: Literature]
View