Cytidine Monophosphate (CID 6131) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(4)
 
 
Inconclusive(1)
 
 
Unspecified(14)
 
 
Top Targets:
ADK(2)
 
 
RNase A canon..(2)
 
 
BioAssay Types:
Literature(28)
 
 
 
 
 
BioActivity Types:
IC50(4)
 
 
 
Ki(4)
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 28   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103272478]
ED50 0.05In vitro cytotoxicity with cleavage by phosphodiesterase-I concentration for 50% loss of viability was determined at 72 hours. [AID98043, Type: Literature]
View
2
[SID103272478]
IC50 0.1In vitro cytotoxicity of compounds were determined on Inhibition of human leukemia cell line(CCRF-CEM) . [AID43713, Type: Literature]
View
3
[SID103272478]
ID50 0.35Growth inhibition of cultured L1210 mouse leukemia cells was determined [AID98676, Type: Literature]
View
4
[SID103272478]
IC50 0.41Inhibitory concentration on multidrug-resistant L1210 leukemia cells. [AID101082, Type: Literature]
View
5
[SID103272478]
IC50 0.43Inhibitory concentration on parentral (sensitive) L1210 leukemia cells. [AID101083, Type: Literature]
View
6
[SID103272478]
ID50 1.5Growth inhibition of B16 mouse melanoma cells in culture was determined [AID38074, Type: Literature]
View
7
[SID103272478]
 Inhibition of aspermatogenic activity of bovine pancreatic ribonuclease A in mouse ICR assessed as weight of the testes at 1:1 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469228, Type: Literature]
View
8
[SID103272478]
 Inhibition of aspermatogenic activity of bovine pancreatic ribonuclease A in mouse ICR assessed as width of spermatogenic layer at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469224, Type: Literature]
View
9
[SID103272478]
 Inhibition of aspermatogenic activity of bovine pancreatic ribonuclease A in mouse ICR assessed as diameter of somniferous tubule at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469221, Type: Literature]
View
10
[SID103272478]
Km 56Activity of human YMPK expressed in Huh7 cells assessed as phosphorylation by coupled enzyme assay [AID278934, Type: Literature]UMP-CMP kinase [gi:12644008]
View
11
[SID103272478]
Ki 64Inhibitory activity evaluated against alpha-2,6-sialyltransferase from rat liver [AID218819, Type: Literature]
View
12
[SID103272478]
Ki 65Inhibitory activity evaluated against alpha-2,3-sialyltransferase from rat liver [AID218818, Type: Literature]
View
13
[SID103272478]
IC50 100In vitro inhibition of UDP-[3H]-GlcNAc import into the lumen of the Golgi membranes from rabbit liver homogenate. [AID74259, Type: Literature]
View
14
[SID103272478]
Ki 844.2Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6 [AID469231, Type: Literature]Ribonuclease pancreatic [gi:48429071]
View
15
[SID103272478]
Kd 903.63Binding affinity to Escherichia coli BL21 (DE3) IspF at 10 degC in pH 7 sodium phosphate buffer by SPR binding assay [AID415022, Type: Literature]
View
16
[SID103272478]
Ki 1557.9Inhibition of bovine seminal ribonuclease assessed as enzyme activity by spectrophotometric method at pH 6 [AID469230, Type: Literature]Seminal ribonuclease [gi:133237]
View
17
[SID103272478]
 Ratio of Kcat to Km for YMPK activity expressed in Huh7 cells [AID278935, Type: Literature]UMP-CMP kinase [gi:12644008]
View
18
[SID103272478]
 Binding energy by using the equation deltaG obsd = -RT ln KD [AID227718, Type: Literature]
View
19
[SID103272478]
 Ratio of IC50 for Parental L1210 to that of multidrug resistant L1210. [AID229265, Type: Literature]
View
20
[SID103272478]
 Percent of Monophosphate forms of compound at 4 hr after phosphorylation by nucleoside monophosphate kinase [AID146812, Type: Literature]
View
21
[SID103272478]
 Percent of diphosphate forms of compound at 4 hr after phosphorylation by nucleoside monophosphate kinase [AID146814, Type: Literature]
View
22
[SID103272478]
 Percent of triphosphate forms of compound at 4 hr after phosphorylation by nucleoside monophosphate kinase [AID146818, Type: Literature]
View
23
[SID103272478]
 Inhibition of L1210/0 cell proliferation [AID99156, Type: Literature]
View
24
[SID103272478]
 Inhibition of L1210/arac cell proliferation at 200 ug/mL; IA means Inactive [AID99187, Type: Literature]
View
25
[SID103272478]
 Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as width of spermatogenic layer at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469225, Type: Literature]
View
26
[SID103272478]
 Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as weight of the testes at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469227, Type: Literature]
View
27
[SID103272478]
 Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as diameter of somniferous tubule at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes [AID469222, Type: Literature]
View
28
[SID103272478]
 Inhibitory concentration at which there is accumulation of UDP-[3H]-GlcNAc in the lumen of the Golgi membranes; Not determined [AID74254, Type: Literature]
View