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Androstenedione (CID 6128) - Compound BioActivity Data
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BioActivity Outcomes:
Active(59)
 
 
Inactive(1488)
 
 
Inconclusive(162)
 
 
Unspecified(40)
 
 
Top Targets:
NR LBD PPAR(40)
 
 
 
NR LBD ER(29)
 
 
 
 
7TM GPCR Srx(28)
 
 
NR LBD AR(25)
 
 
 
 
7TM GPCR Srsx(24)
 
 
BioAssay Types:
Confirmatory(872)
 
 
 
 
 
Screening(621)
 
 
 
 
Literature(136)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(778)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(11)
 
 
Kd(1)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1120    Data Row: 1749   Total Pages: 88   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168552]
Ki 0.02Binding affinity for aromatase cytochrome P45019A1 by analysis of Dixon plot [AID53887, Type: Literature]Aromatase [gi:117293]
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2
[SID144209467]
Potency-Replicate_1 0.0268qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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3
[SID103168552]
Km 0.03Binding affinity for Cytochrome P450 19A1 [AID53899, Type: Literature]Aromatase [gi:117293]
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4
[SID103168552]
Kd 0.03467Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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5
[SID103168552]
Km 0.051Apparent Km value was determined [AID27326, Type: Literature]
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6
[SID144210896]
Potency-Replicate_1 0.0545qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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7
[SID103168552]
Km 0.0575Michaelis-Menten constant against Aromatase [AID254561, Type: Literature]Aromatase [gi:117293]
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8
[SID103168552]
Km 0.06Km for Cytochrome P450 19A1 [AID53901, Type: Literature]
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9
[SID103168552]
IC50 0.064In vitro antagonist activity against rat prostatic androgen receptor (AR) [AID39178, Type: Literature]
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10
[SID144204444]
Potency-Replicate_1 0.1059qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
11
[SID144209467]
Ratio Potency (uM) 0.172013qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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12
[SID144209467]
Potency-Replicate_1 0.1917qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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13
[SID17389252]
Potency 0.2239qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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14
[SID103168552]
IC50 0.3In vitro competitive inhibitory activity was measured on Cytochrome P450 19A1 of human placental microsomes [AID53551, Type: Literature]
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15
[SID144210896]
Ratio Potency (uM) 0.388952qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144210896]
Potency-Replicate_1 0.389qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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17
[SID103168552]
IC50 0.489Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 3 [AID215941, Type: Literature]
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18
[SID103168552]
IC50 0.65Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 2 [AID215940, Type: Literature]
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19
[SID103168552]
IC50 0.758Inhibitory concentration against type-3 17-beta-HSD expressed in HEK293 cells [AID215943, Type: Literature]Testosterone 17-beta-dehydrogenase 3 [gi:1169300]
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20
[SID103168552]
IC50 0.758Ability to inhibit the Type-3 17-beta- hydroxysteroid dehydrogenase activity transfected in human embryonic kidney (HEK)-293 cells experiment 1 [AID215939, Type: Literature]
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