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Thioctic Acid (CID 6112) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(186)
 
 
Inconclusive(20)
 
 
Unspecified(237)
 
 
Top Targets:
7tm 4(39)
 
 
 
 
p450(8)
 
 
Esterase lipa..(7)
 
 
 
HELICc(6)
 
 
 
prostaglandin..(6)
 
 
BioAssay Types:
Confirmatory(280)
 
 
 
 
Literature(132)
 
 
 
 
 
Screening(18)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(163)
 
 
 
 
IC50(132)
 
 
 
Kd(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 417    Data Row: 456   Total Pages: 23   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103372397]
IC50 0.001Inhibition of human AchE [AID314091, Type: Literature]Acetylcholinesterase [gi:113037]
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2
[SID103372397]
IC50 1.95Antioxidant activity assessed as hypochlorous acid scavenging activity by fluorescent rhodamine formation assay [AID453279, Type: Literature]
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3
[SID103372397]
IC50 2.4Hypochlorous acid scavenging activity assessed as inhibition of DHR oxidation [AID289322, Type: Literature]
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4
[SID103372397]
IC50 11Antioxidant activity assessed as hydroxyl radical scavenging activity [AID347225, Type: Literature]
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5
[SID103372397]
IC50 19.6Neuroprotective effect was measured by its ability to protect mouse hippocampal neuronal HT-22 cell lines from oxidative stress caused by glutamate [AID84280, Type: Literature]
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6
[SID103372397]
Antiapoptotic activity in rat L6 cells assessed as suppression of 23.5 mM D-glucose-induced JNK-46 phosphorylation at 2 mM after 30 mins by Western blot analysis [AID778728, Type: Literature]
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7
[SID103372397]
Antiapoptotic activity in rat L6 cells assessed as suppression of 23.5 mM D-glucose-induced JNK-54 phosphorylation at 2 mM after 30 mins by Western blot analysis [AID778729, Type: Literature]
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8
[SID103372397]
Antioxidant activity in rat L6 cells assessed as trolox equivalents of ABTS free radical scavenging activity at 2 mM after 2 hrs by ELISA reader analysis in presence of 23.5 mM D-glucose [AID778732, Type: Literature]
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9
[SID103372397]
Cytoprotective activity in rat L6 cells assessed as increase in glucose oxidase-reduced cell survival at 2 mM incubated for 30 mins prior to glucose oxidase challenge measured after 5 hrs by MTT assay in presence of 23.5 mM D-glucose [AID778734, Type: Literature]
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10
[SID103372397]
Inhibition of mushroom tyrosinase using L-DOPA as substrate at 2.5 mM preincubated for 10 to 15 mins prior to substrate addition by spectrophotometry [AID776261, Type: Literature]
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11
[SID103372397]
Antihyperglycemic activity in rat L6 cells assessed as increase in [3H]dGlc uptake at 2 mM after 30 mins by liquid scintillation counting analysis [AID778750, Type: Literature]
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12
[SID103372397]
Radical reducing potency by ABTS cation radical reduction assay per 30 mins at 1 umol/mL [AID264481, Type: Literature]
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13
[SID103372397]
Induction of human myc epitope-tagged GLUT1 translocation to plasma membrane overexpressed in rat L6 cells at 2 mM after 30 mins by immunocolorimetric analysis in presence of 23.5 mM D-glucose [AID778746, Type: Literature]Solute carrier family 2, facilitated glucose transporter member 1 [gi:115502394]
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14
[SID103372397]
Kd 10Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor) [AID239871, Type: Literature]
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15
[SID103372397]
Kd 10Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor) [AID239872, Type: Literature]
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16
[SID103372397]
Kd 10Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor) [AID239873, Type: Literature]
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17
[SID103372397]
IC50 54.86Antioxidant activity against formation of ROS was determined in t-BuOOH treated LNCaP cells after 24 hr of incubation with compounds (1-100 uM) [AID248861, Type: Literature]
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18
[SID103372397]
EC50 68Cytoprotective activity in H2O2-induced human ECV304 cells assessed as proliferation rate incubated for 24 hrs prior to H2O2-challenge measured after 12 hrs by MTT assay [AID1079689, Type: confirmatory]
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19
[SID103372397]
EC50 121.6Ability for prevention of GSH depletion was measured in mouse [AID127631, Type: Literature]
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20
[SID103372397]
EC50 250Induction of apoptosis in human HT-29 cells [AID481542, Type: Literature]
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