AC1O0WHL (CID 6104167) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(96)
 
 
Inactive(394)
 
 
Inconclusive(30)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
 
7TM GPCR Srsx(8)
 
 
PTPc(7)
 
 
Tryp SPc(7)
 
 
 
BioAssay Types:
Screening(296)
 
 
 
 
Confirmatory(208)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(19)
 
 
 
AC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 521    Data Row: 521   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24823674]
Potency 0.0398qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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2
[SID24823674]
Potency 0.259qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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3
[SID24823674]
Potency 0.3548qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID24823674]
Potency 0.3548qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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5
[SID24823674]
IC50 0.53Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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6
[SID24823674]
IC50 0.53Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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7
[SID24823674]
IC50 0.53Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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8
[SID24823674]
Potency 0.7079qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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9
[SID24823674]
Potency 0.7079qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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10
[SID24823674]
IC50 0.752Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence resonance energy transfer selectivity assay [AID624384, Type: confirmatory]SUMO2 gene product [Homo sapiens] [gi:54792071]
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11
[SID24823674]
Potency 0.7943qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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12
[SID24823674]
Potency 0.7943qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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13
[SID24823674]
Potency 0.7943qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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14
[SID24823674]
Potency 1.122HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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15
[SID24823674]
Potency 1.4125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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16
[SID24823674]
Potency 1.5849qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID24823674]
Potency 1.5849qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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18
[SID24823674]
Potency 1.6231Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID489007, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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19
[SID24823674]
Potency 1.7783qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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20
[SID24823674]
Potency 1.9953qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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21
[SID24823674]
Potency 1.9953CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID493169, Type: confirmatory]enteropeptidase precursor [Homo sapiens] [gi:223942069]
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22
[SID24823674]
EC50 2.249Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
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23
[SID24823674]
EC50 2.249Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
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24
[SID24823674]
IC50 2.443Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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25
[SID24823674]
IC50 2.443Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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26
[SID24823674]
IC50 2.443Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay using pCAP substrate [AID435027, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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27
[SID24823674]
IC50 2.6867Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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28
[SID24823674]
IC50 2.6867Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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29
[SID24823674]
IC50 2.6867Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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30
[SID24823674]
Potency 3.1623qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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31
[SID24823674]
Potency 3.1623qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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32
[SID24823674]
IC50 3.28MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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33
[SID24823674]
IC50 3.28MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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34
[SID24823674]
IC50 3.446Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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35
[SID24823674]
Potency 3.5481qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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36
[SID24823674]
IC50 4.404Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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37
[SID24823674]
IC50 4.404Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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38
[SID24823674]
IC50 4.404Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 [AID435024, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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39
[SID24823674]
IC50 4.43Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID855, Type: confirmatory]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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40
[SID24823674]
IC50 4.43Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID855, Type: confirmatory]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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41
[SID24823674]
Potency 4.4668Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a [AID493170, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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42
[SID24823674]
Potency 4.4668Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a [AID493170, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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43
[SID24823674]
IC50 4.53951LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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44
[SID24823674]
IC50 4.53951LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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45
[SID24823674]
IC50 4.53951LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies. [AID2126, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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46
[SID24823674]
IC50 4.892Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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47
[SID24823674]
IC50 4.892Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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48
[SID24823674]
IC50 4.892Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 [AID435032, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
49
[SID24823674]
IC50 5.46798uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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50
[SID24823674]
IC50 5.46798uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
View