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Methylene Blue (CID 6099) - Compound BioActivity Data
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BioActivity Outcomes:
Active(249)
 
 
Inactive(631)
 
 
Inconclusive(113)
 
 
Unspecified(40)
 
 
Top Targets:
NR LBD PPAR(28)
 
 
 
 
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(19)
 
 
 
Pyr redox dim(16)
 
 
 
 
 
NR LBD ER(14)
 
 
 
BioAssay Types:
Screening(501)
 
 
 
 
Confirmatory(375)
 
 
 
 
 
Literature(81)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(320)
 
 
 
 
 
IC50(64)
 
 
 
 
 
EC50(26)
 
 
 
 
AC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 866    Data Row: 1033   Total Pages: 52   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103568829]
IC50 0.0054Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation [AID317969, Type: Literature]
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2
[SID103568829]
EC50 0.0065Antiplasmodial activity after 42 hrs against chloroquine-resistant Plasmodium falciparum K1 treated for 6 hrs by Giemsa stain [AID423535, Type: Literature]
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3
[SID24811249]
Potency 0.0073qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID103568829]
EC50 0.017In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 [AID160054, Type: Literature]
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5
[SID144212404]
Ratio Potency (uM) 0.0815189qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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6
[SID144206050]
Potency 0.1663qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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7
[SID144212404]
Potency-Replicate_1 0.3857qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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8
[SID24811249]
Absolute IC50 0.39Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) [AID1275, Type: confirmatory]neutrophil cytosol factor 1 [Homo sapiens] [gi:115298672]
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9
[SID144206050]
Potency-Replicate_1 0.4216qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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10
[SID170465461]
Ratio Potency (uM) 0.438094qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID144206050]
Potency-Replicate_1 0.4731qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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12
[SID103568829]
IC50 0.61Inhibition of His-tagged human recombinant 2N4R tau protein aggregation assessed as inhibition octadecyl sulphate-induced fibrillation by filter trap assay [AID375602, Type: Literature]
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13
[SID144212404]
Potency-Replicate_1 0.6859qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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14
[SID144212404]
Potency-Replicate_1 0.6859qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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15
[SID24811249]
EC50 0.72A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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16
[SID24811249]
Potency 0.7305qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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17
[SID24811249]
EC50 0.742TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]NCOA2 protein [Homo sapiens] [gi:62201602]
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18
[SID24811249]
EC50 0.742TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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19
[SID144206050]
Potency-Replicate_1 0.7498qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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20
[SID24811249]
AC50_uM 0.936FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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