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Adenosine (CID 60961) - Compound BioActivity Data
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BioActivity Outcomes:
Active(126)
 
 
Inactive(1191)
 
 
Inconclusive(35)
 
 
Unspecified(261)
 
 
Top Targets:
7TM GPCR Srsx(58)
 
 
 
 
 
7TM GPCR Srx(31)
 
 
 
Tryp SPc(15)
 
 
NR LBD PPAR(14)
 
 
 
alkPPc(14)
 
 
BioAssay Types:
Screening(586)
 
 
 
 
Confirmatory(475)
 
 
 
 
 
Literature(458)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(409)
 
 
 
 
 
IC50(93)
 
 
 
 
EC50(36)
 
 
 
 
Ki(29)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1339    Data Row: 1613   Total Pages: 33   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168984]
EC50 0.00012Coronary vasoactivity in dogs [AID59110, Type: Literature]
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2
[SID103168984]
Ki 0.005Binding affinity for Adenosine A2 receptor in corpora striata of rats using [3H]NECA [AID33726, Type: Literature]Adenosine receptor A2b [gi:112939]
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3
[SID103168984]
Ki 0.005Binding affinity for Adenosine A2 receptor in corpora striata of rats using [3H]NECA [AID33726, Type: Literature]Adenosine receptor A2a [gi:8928539]
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4
[SID103168984]
Ki 0.0051Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor [AID32324, Type: Literature]Adenosine receptor A1 [gi:2827766]
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5
[SID103168984]
Ki 0.01Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor [AID32358, Type: Literature]Adenosine receptor A1 [gi:2827766]
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6
[SID103168984]
Ki 0.01Evaluated for the binding affinity towards the Adenosine A1 receptor in corpora striata of rats using [3H]CHA as radioligand. [AID32361, Type: Literature]
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7
[SID103168984]
Ki 0.0128Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. [AID32503, Type: Literature]
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8
[SID103168984]
Ki 0.0128Affinity for Adenosine A1 receptor determined by [3H]N6-cyclohexyladenosine binding to rat brain membranes [AID31852, Type: other]Adenosine receptor A1 [gi:2827766]
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9
[SID103168984]
Ki 0.02Binding affinity to A2A adenosine receptor [AID647885, Type: Literature]
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10
[SID103168984]
Ki 0.03Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranes [AID32896, Type: Literature]Adenosine receptor A2a [gi:8928539]
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11
[SID103168984]
Ki 0.037Affinity for Adenosine A2 receptor determined by [3H]NECA binding to rat striatal membranes [AID33431, Type: other]Adenosine receptor A2a [gi:8928539]
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12
[SID103168984]
Ki 0.037Affinity for Adenosine A2 receptor determined by [3H]NECA binding to rat striatal membranes [AID33431, Type: other]Adenosine receptor A2b [gi:112939]
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13
[SID103168984]
Ki 0.037Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes. [AID33733, Type: Literature]
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14
[SID103168984]
EC50 0.039Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay [AID699044, Type: Literature]Adenosine receptor A1 [gi:231473]
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15
[SID103168984]
EC50 0.05129Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation [AID30504, Type: Literature]
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16
[SID103168984]
EC50 0.05129Coronary arteries vasodilation at the adenosine A2 receptor in langendorff guinea pig heart preparation [AID30507, Type: Literature]
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17
[SID103168984]
ED50 0.08Concentration that inhibited the growth of cultured human detroit 98 cells. [AID56621, Type: Literature]
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18
[SID103168984]
Ki 0.1Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in CHO cells [AID33360, Type: Literature]Adenosine receptor A3 [gi:2506479]
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19
[SID103168984]
IC50 0.15Concentration required to increase Adenosine A2A receptor mediated P12 Adenylate cyclase activity [AID34467, Type: Literature]
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20
[SID855932]
IC50 0.199526Dose responses of compounds that inhibit the Choline Transporter (CHT) - 10 point CRC [AID588401, Type: confirmatory]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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21
[SID103168984]
EC50 0.29Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium level [AID489229, Type: Literature]Adenosine receptor A3 [gi:1351831]
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22
[SID103168984]
EC50 0.29Agonist activity at human adenosine A3 receptor expressed in CHO cells [AID590343, Type: Literature]Adenosine receptor A3 [gi:1351831]
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23
[SID103168984]
ED50 0.3Concentration that inhibited the growth of Mouse L cells. [AID139636, Type: Literature]
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24
[SID103168984]
EC50 0.31Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as increase of intracellular calcium level [AID489230, Type: Literature]Adenosine receptor A1 [gi:231473]
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25
[SID103168984]
EC50 0.31Agonist activity at human adenosine A1 receptor expressed in CHO cells [AID590344, Type: Literature]Adenosine receptor A1 [gi:231473]
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26
[SID103168984]
ID50 0.4In vitro inhibition of growth of L1210 mouse leukemic cells [AID96809, Type: Literature]
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27
[SID855932]
IC50 0.570653Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC [AID504840, Type: confirmatory]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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28
[SID103168984]
EC50 0.7Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as increase of intracellular calcium level [AID489231, Type: Literature]Adenosine receptor A2a [gi:543740]
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29
[SID103168984]
EC50 0.7Agonist activity at human adenosine A2A receptor expressed in CHO cells [AID590428, Type: Literature]Adenosine receptor A2a [gi:543740]
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30
[SID103168984]
IC50 0.7Compound was evaluated for cytotoxicity against H.Ep.-2 cells , and concentration required to inhibit the growth of treated cells to 50% of untreated control . [AID79419, Type: Literature]
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31
[SID103168984]
Km 0.7Compound was tested for inhibition of Adenosine transporter P2 type by using [2-3H]adenosine as radioligand in Trypanosoma equiperdum [AID34013, Type: Literature]
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32
[SID855932]
EC50 0.759Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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33
[SID103168984]
Km 0.82Enzyme kinetic constant for S-adenosyl-L-homocysteine hydrolase [AID199751, Type: Literature]
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34
[SID103168984]
Ki 0.93Inhibition of rabbit liver adenosine kinase [AID322618, Type: Literature]
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35
[SID103168984]
EC50 1.04Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay [AID264108, Type: Literature]Adenosine receptor A3 [gi:1351831]
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36
[SID103168984]
EC50 1.41Agonist activity at human A1AR assessed as induction of Ca2+ ion mobilization by orthogonal functional assay [AID699042, Type: Literature]Adenosine receptor A1 [gi:231473]
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37
[SID103168984]
IC50 1.8Inhibition of epinephrine induced human blood platelet aggregation [AID44746, Type: Literature]
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38
[SID103168984]
Km 2.4Binding affinity at Toxoplasma gondii adenosine kinase. [AID33981, Type: Literature]Adenosine kinase [gi:18203488]
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39
[SID103168984]
ID50 2.4Compound was evaluated for antiviral activity expressed as ID50 for the inhibition of cellular DNA and protein synthesis in wild-type cells [AID219247, Type: Literature]
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40
[SID103168984]
IC50 2.5Inhibition of ADP induced human blood platelet aggregation [AID44745, Type: Literature]
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41
[SID103168984]
EC50 3.38844Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the A1 adenosine receptor in langendorff guinea pig heart preparation [AID32145, Type: Literature]Adenosine receptor A1 [gi:1351830]
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42
[SID103168984]
EC50 3.38844Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparation [AID32148, Type: Literature]Adenosine receptor A1 [gi:1351830]
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43
[SID103168984]
Km 5Michaelis constant was determined against mammalian Adenosine deaminase [AID33975, Type: Literature]
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44
[SID103168984]
Km 5.5Activity of rabbit liver adenosine kinase [AID322616, Type: Literature]
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45
[SID103168984]
IC50 5.94Concentration that inhibits platelet aggregation induced by ADP (7 uM) by 50% [AID225585, Type: Literature]
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46
[SID103168984]
IC50 6In vitro inhibitory activity was measured against tumor necrosis factor-alpha production [AID90490, Type: Literature]
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47
[SID103168984]
Km 7.8Compound was evaluated for the kinetic constant on adenosine deaminase and expressed as Km [AID33973, Type: Literature]
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48
[SID103168984]
Ki 8.9Binding affinity to purified Toxoplasma gondii adenosine kinase [AID343761, Type: Literature]Adenosine kinase [gi:18203488]
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49
[SID103168984]
ED50 10Inhibition of adenosine kinase-induced MMPR (6-methylmercaptopurine riboside) toxicity in human CEM lymphoblasts [AID47645, Type: Literature]Adenosine kinase [gi:6840802]
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50
[SID103168984]
ID50 10Inhibition of human CEM lymphoblast proliferation [AID47646, Type: Literature]
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