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Adenosine (CID 60961) - Compound BioActivity Data
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BioActivity Outcomes:
Active(143)
 
 
Inactive(1211)
 
 
Inconclusive(31)
 
 
Unspecified(264)
 
 
Top Targets:
7tm 4(90)
 
 
 
 
 
Tryp SPc(15)
 
 
NR LBD PPAR(14)
 
 
alkPPc(14)
 
 
CAP ED(13)
 
 
 
 
BioAssay Types:
Screening(587)
 
 
 
 
Confirmatory(494)
 
 
 
 
 
Literature(490)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(411)
 
 
 
 
 
IC50(93)
 
 
 
 
EC50(36)
 
 
 
 
Ki(33)
 
 
 
Kd(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1354    Data Row: 1649   Total Pages: 83   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168984]
EC50 0.00012Coronary vasoactivity in dogs [AID59110, Type: Literature]
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2
[SID103168984]
Ki 0.005Binding affinity for Adenosine A2 receptor in corpora striata of rats using [3H]NECA [AID33726, Type: Literature]Adenosine receptor A2b [gi:112939]
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3
[SID103168984]
Ki 0.005Binding affinity for Adenosine A2 receptor in corpora striata of rats using [3H]NECA [AID33726, Type: Literature]Adenosine receptor A2a [gi:8928539]
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4
[SID103168984]
Ki 0.0051Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor [AID32324, Type: Literature]Adenosine receptor A1 [gi:2827766]
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5
[SID103168984]
Ki 0.01Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor [AID32358, Type: Literature]Adenosine receptor A1 [gi:2827766]
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6
[SID103168984]
Ki 0.01Evaluated for the binding affinity towards the Adenosine A1 receptor in corpora striata of rats using [3H]CHA as radioligand. [AID32361, Type: Literature]
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7
[SID103168984]
Ki 0.0128Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. [AID32503, Type: Literature]
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8
[SID103168984]
Ki 0.0128Affinity for Adenosine A1 receptor determined by [3H]N6-cyclohexyladenosine binding to rat brain membranes [AID31852, Type: confirmatory]Adenosine receptor A1 [gi:2827766]
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9
[SID103168984]
Ki 0.02Binding affinity to A2A adenosine receptor [AID647885, Type: Literature]
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10
[SID103168984]
Ki 0.03Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranes [AID32896, Type: Literature]Adenosine receptor A2a [gi:8928539]
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11
[SID170481835]
Ki 0.0309Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Thermostabilised Human A2a Receptor With Adenosine Bound [gi:333361053]
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12
[SID170481835]
Ki 0.0309Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Thermostabilised Human A2a Receptor With Adenosine Bound [gi:333361053]
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13
[SID103168984]
Ki 0.037Affinity for Adenosine A2 receptor determined by [3H]NECA binding to rat striatal membranes [AID33431, Type: confirmatory]Adenosine receptor A2a [gi:8928539]
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14
[SID103168984]
Ki 0.037Affinity for Adenosine A2 receptor determined by [3H]NECA binding to rat striatal membranes [AID33431, Type: confirmatory]Adenosine receptor A2b [gi:112939]
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15
[SID103168984]
Ki 0.037Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes. [AID33733, Type: Literature]
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16
[SID103168984]
EC50 0.039Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay [AID699044, Type: Literature]Adenosine receptor A1 [gi:231473]
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17
[SID103168984]
EC50 0.05129Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation [AID30504, Type: Literature]
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18
[SID103168984]
EC50 0.05129Coronary arteries vasodilation at the adenosine A2 receptor in langendorff guinea pig heart preparation [AID30507, Type: Literature]
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19
[SID103168984]
ED50 0.08Concentration that inhibited the growth of cultured human detroit 98 cells. [AID56621, Type: Literature]
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20
[SID103168984]
Ki 0.1Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in CHO cells [AID33360, Type: Literature]Adenosine receptor A3 [gi:2506479]
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