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1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole (CID 6095481) - Compound BioActivity Data
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BioActivity Outcomes:
Active(58)
 
 
Inactive(767)
 
 
Inconclusive(105)
 
 
Unspecified(34)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
NR LBD ER(24)
 
 
 
 
 
TRP 2(20)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(12)
 
 
 
BioAssay Types:
Confirmatory(499)
 
 
 
 
 
Screening(378)
 
 
 
 
Literature(49)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(397)
 
 
 
 
 
IC50(38)
 
 
 
 
EC50(13)
 
 
 
AC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 761    Data Row: 964   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103357561]
EC50 0.0001Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707063, Type: Literature]Estrogen receptor [gi:544257]
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2
[SID103357561]
EC50 0.003Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control [AID707065, Type: Literature]Estrogen receptor [gi:544257]
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3
[SID26752190]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID90341714]
Potency 0.2908qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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5
[SID50104850]
Potency 1.9953Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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6
[SID50104850]
Potency 1.9953qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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7
[SID90341714]
Potency 2.0596qHTS for Activators of Parkin Expression: LOPAC Validation Assay (NLuc Reporter) [AID720572, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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8
[SID11114080]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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9
[SID26732630]
AC50_uM 2.916Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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10
[SID11111273]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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11
[SID11111273]
Potency 3.1623qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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12
[SID11114080]
Potency 3.1623qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID11114080]
Potency 3.1623qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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14
[SID26732630]
AC50_uM 3.781Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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15
[SID26732630]
AC50_uM 4.366Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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16
[SID26732630]
EC50_uM 4.88Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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17
[SID26732630]
AC50_uM 6.097Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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18
[SID103357561]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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19
[SID11111273]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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20
[SID11111273]
Potency 10qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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21
[SID11111273]
Potency 10qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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22
[SID11114080]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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23
[SID11114080]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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24
[SID90341714]
Potency 16.3601qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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25
[SID26752190]
Potency 22.3872qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling [AID588537, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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26
[SID90341714]
Potency 25.1189qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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27
[SID103357561]
IC50 27.2Cytotoxicity in hormone-dependent human MCF7 cells assessed as growth inhibition incubated for 4 day s by crystal violet assay [AID707062, Type: Literature]
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28
[SID26752190]
Potency 28.1838qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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29
[SID11111273]
Potency 39.8107qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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30
[SID26752190]
Potency 70.7946qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
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31
[SID26732630]
EC50_uM 216.3Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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32
[SID11114080]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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33
[SID11114080]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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34
[SID11111273]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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35
[SID11114080]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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36
[SID26732630]
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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37
[SID26732630]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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38
[SID26732630]
Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]potassium voltage-gated channel subfamily E member 1 [Homo sapiens] [gi:189095237]
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39
[SID103357561]
Estrogenic activity at estrogen receptor in human MCF7:D5L cells co-expressing ERE assessed as induction of luciferase gene expression at 100 nM after 16 hrs by microplate reader relative to untreated vehicle control [AID658964, Type: Literature]
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40
[SID103357561]
Estrogenic activity at estrogen receptor in human Ishikawa cells assessed as induction of alkaline phosphatase expression at 100 nM after 72 hrs by microplate reader [AID658974, Type: Literature]
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41
[SID103357561]
Down regulation of ERalpha human MCF7 cells at 10 uM by Western blotting [AID707059, Type: Literature]
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42
[SID26732630]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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43
[SID26732630]
Second counter screen for compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID434979, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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44
[SID26732630]
Confirmatory screen for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2555, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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45
[SID26732630]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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46
[SID26732630]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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47
[SID26732630]
Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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48
[SID26732630]
Counter screen assay of the parental CHO cells for identification of compounds that inhibit KCNQ1 potassium channels [AID588366, Type: other]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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49
[SID26732630]
Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
View
50
[SID17405137]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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