Papaverine (CID 6084) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(54)
 
 
Inactive(944)
 
 
Inconclusive(84)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(14)
 
 
Tryp SPc(12)
 
 
7TM GPCR Srsx(12)
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(569)
 
 
 
 
Confirmatory(427)
 
 
 
 
 
Literature(21)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(288)
 
 
 
 
 
IC50(48)
 
 
 
 
EC50(15)
 
 
 
AC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 969    Data Row: 1098   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103307406]
ID50 0.019Inhibitory effect on the response of isolated ileum to transmural electrical stimulation in guinea pig (anti-TMS activity) was determined [AID79532, Type: Literature]
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2
[SID26747626]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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3
[SID26747626]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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4
[SID26747626]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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5
[SID56422444]
AC50 2.48Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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6
[SID855961]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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7
[SID855961]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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8
[SID855961]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
9
[SID855961]
EC50 3.01Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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10
[SID56422444]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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11
[SID144203777]
Potency 5.0807qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID144203777]
Potency 5.0807qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID144203777]
Potency 5.0807qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID855961]
AC50 5.657Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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15
[SID56422444]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID56422444]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID56422444]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
18
[SID855961]
EC50 7.303Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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19
[SID103307406]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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20
[SID56422444]
AC50 8.06Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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21
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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24
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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25
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
26
[SID26747626]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
27
[SID855961]
EC50 8.857Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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28
[SID26747626]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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29
[SID50106832]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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30
[SID50106832]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
31
[SID50106832]
Potency 14.1254qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
32
[SID56422444]
Potency 14.581Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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33
[SID56422444]
Potency 14.581Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
34
[SID56422444]
Potency 14.581Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
35
[SID56422444]
Potency 14.581Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
36
[SID56422444]
AC50 20.83Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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37
[SID103307406]
IC50 21Antiviral activity against HCMV in MRC5 cells by plaque reduction assay [AID293734, Type: Literature]
View
38
[SID26747626]
Potency 50.1187Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
View
39
[SID855961]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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40
[SID855961]
 Confirmatory screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2032, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
View
41
[SID855961]
 uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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42
[SID855961]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID463073, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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43
[SID855961]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID463073, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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44
[SID56422444]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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45
[SID56422444]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
View
46
[SID56422444]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
View
47
[SID56422444]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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48
[SID56422444]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
View
49
[SID56422444]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
View
50
[SID56422444]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
View