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duloxetine (CID 60835) - Compound BioActivity Data
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BioActivity Outcomes:
Active(116)
 
 
Inactive(358)
 
 
Inconclusive(47)
 
 
Unspecified(59)
 
 
Top Targets:
SLC6sbd SERT(19)
 
 
 
SLC6sbd NET(17)
 
 
SLC6sbd DAT1(16)
 
 
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srx(11)
 
 
 
BioAssay Types:
Screening(200)
 
 
 
 
Literature(184)
 
 
 
 
 
Confirmatory(174)
 
 
 
 
 
BioActivity Types:
Potency(113)
 
 
 
 
 
IC50(72)
 
 
 
 
 
Ki(38)
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 466    Data Row: 580   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103343183]
Ki 8.2e-05Displacement of [3H]-citalopram from Sprague-Dawley rat brain SERT after 1 hr [AID748485, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400629]
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2
[SID103343183]
IC50 0.000316Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptake [AID731054, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103343183]
Ki 0.000501Inhibition of SERT [AID431326, Type: Literature]
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4
[SID103343183]
Ki 0.0008Binding affinity for 5-hydroxytryptamine transporter [AID238655, Type: Literature]
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5
[SID103343183]
Ki 0.0008Ability to inhibit the reuptake of 5-HT at human serotonin transporter [AID204085, Type: Literature]
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6
[SID103343183]
Ki 0.00124Displacement of [3H]-nisoxetine from Sprague-Dawley rat brain NET after 1 hr [AID748484, Type: confirmatory]
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7
[SID103343183]
IC50 0.00158Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptake [AID731055, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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8
[SID103343183]
IC50 0.0023Displacement of [3H]citalopram from human SERT transfected in HEK293 cells after 3 hrs by Wallac counting analysis [AID748489, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103343183]
IC50 0.003Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103343183]
Ki 0.003Displacement of [3H]nisoxetine from rat NET in rat cerebral cortex [AID537543, Type: Literature]Norepinephrine transporter [gi:81890335]
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13
[SID103343183]
Ki 0.0039Inhibition of rat NET [AID717267, Type: Literature]Norepinephrine transporter [gi:81890335]
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14
[SID103343183]
IC50 0.004Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells [AID423862, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells [AID352215, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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16
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK cells [AID387487, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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17
[SID103343183]
IC50 0.004Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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18
[SID103343183]
Ki 0.0046Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry [AID411215, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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19
[SID103343183]
Ki 0.0046Inhibition constant against serotonin transporter [AID254277, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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20
[SID103343183]
Ki 0.0046Inhibition of serotonin uptake into rat synaptosomes [AID187185, Type: Literature]
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