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duloxetine (CID 60835) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(107)
 
 
Inactive(358)
 
 
Inconclusive(47)
 
 
Unspecified(58)
 
 
Top Targets:
SLC6sbd SERT(17)
 
 
 
SLC6sbd NET(16)
 
 
 
SLC6sbd DAT1(15)
 
 
 
 
7TM GPCR Srx(11)
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(200)
 
 
 
 
Literature(184)
 
 
 
 
 
Confirmatory(169)
 
 
 
 
 
BioActivity Types:
Potency(113)
 
 
 
 
 
IC50(67)
 
 
 
 
 
Ki(34)
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 456    Data Row: 570   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103343183]
Ki 0.000501Inhibition of SERT [AID431326, Type: Literature]
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2
[SID103343183]
Ki 0.0008Binding affinity for 5-hydroxytryptamine transporter [AID238655, Type: Literature]
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3
[SID103343183]
Ki 0.0008Ability to inhibit the reuptake of 5-HT at human serotonin transporter [AID204085, Type: Literature]
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4
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103343183]
IC50 0.003Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103343183]
Ki 0.003Displacement of [3H]nisoxetine from rat NET in rat cerebral cortex [AID537543, Type: Literature]Norepinephrine transporter [gi:81890335]
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8
[SID103343183]
Ki 0.0039Inhibition of rat NET [AID717267, Type: Literature]Norepinephrine transporter [gi:81890335]
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9
[SID103343183]
IC50 0.004Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells [AID423862, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID103343183]
IC50 0.004Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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11
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells [AID352215, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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12
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK cells [AID387487, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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13
[SID103343183]
Ki 0.0046Inhibition constant against serotonin transporter [AID254277, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103343183]
Ki 0.0046Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry [AID411215, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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15
[SID103343183]
Ki 0.0046Inhibition of serotonin uptake into rat synaptosomes [AID187185, Type: Literature]
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16
[SID103343183]
Ki 0.005Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting [AID469543, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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17
[SID103343183]
Ki 0.005Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay [AID484002, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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18
[SID103343183]
IC50 0.005Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells [AID423861, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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19
[SID103343183]
Ki 0.005Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells [AID329322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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20
[SID103343183]
Ki 0.00597Inhibition of human NET [AID717270, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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21
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT from human SERT expressed in HEK293 cells [AID306267, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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22
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cells [AID268714, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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23
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells [AID269937, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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24
[SID103343183]
IC50 0.0066Inhibition of human SERT [AID321309, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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25
[SID103343183]
IC50 0.0066Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from human cloned SERT expressed in HEK293 cells by microplate scintillation counter [AID345212, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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26
[SID103343183]
Ki 0.0075Ability to inhibit the reuptake of NE at human norepinephrine transporter [AID145366, Type: Literature]
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27
[SID103343183]
Ki 0.0075Binding affinity for Norepinephrine transporter [AID238568, Type: Literature]
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28
[SID103343183]
Ki 0.00794Inhibition of NET [AID431327, Type: Literature]
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29
[SID103343183]
IC50 0.0089Inhibition of human NET [AID321308, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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30
[SID103343183]
IC50 0.0089Displacement of Levo[ring-2,5,6-3H]norepinephrine from human cloned NET expressed in HEK293 cells by microplate scintillation counter [AID345211, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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31
[SID103343183]
Ki 0.016Inhibition constant against norepinephrine transporter [AID254282, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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32
[SID103343183]
Ki 0.016Inhibition of norepinephrine uptake into rat synaptosomes [AID187184, Type: Literature]
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33
[SID103343183]
Ki 0.016Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry [AID411214, Type: Literature]Norepinephrine transporter [gi:81890335]
View
34
[SID103343183]
IC50 0.019Inhibition of [3H]NA reuptake at NA transporter in HEK293 cells [AID268715, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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35
[SID103343183]
IC50 0.019Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cells [AID269938, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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36
[SID103343183]
IC50 0.019Inhibition of [3H]NA from human NET expressed in HEK293 cells [AID306268, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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37
[SID103343183]
Ki 0.045Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells [AID329323, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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38
[SID103343183]
Ki 0.045Displacement of [3H]noradrenaline from human NET receptor expressed in HEK293 cells by scintillation counting [AID469544, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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39
[SID103343183]
Ki 0.045Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assay [AID484003, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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40
[SID103343183]
Ki 0.24Binding affinity for Dopamine transporter [AID238456, Type: Literature]
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41
[SID103343183]
Ki 0.24Ability to inhibit the reuptake of dopamine at human dopamine transporter [AID64504, Type: Literature]
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42
[SID103343183]
Ki 0.25119Inhibition of DAT [AID431328, Type: Literature]
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43
[SID103343183]
Ki 0.37Inhibition of dopamine uptake into rat synaptosomes [AID187183, Type: Literature]
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44
[SID103343183]
IC50 0.37Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometry [AID411213, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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45
[SID103343183]
Ki 0.37Inhibition constant against dopamine transporter [AID254272, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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46
[SID103343183]
Ki 0.435Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells [AID329324, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
View
47
[SID103343183]
Ki 0.435Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assay [AID484004, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
View
48
[SID103343183]
Ki 0.435Displacement of [3H]dopamine from human DAT receptor expressed in HEK293 cells by scintillation counting [AID469545, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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49
[SID103343183]
IC50 0.59Inhibition of [3H]DA uptake at human DAT expressed in HEK293 cells [AID423863, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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50
[SID103343183]
IC50 0.66Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from human cloned DAT expressed in HEK293 cells by microplate scintillation counter [AID345213, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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