duloxetine (CID 60835) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(105)
 
 
Inactive(317)
 
 
Inconclusive(46)
 
 
Unspecified(41)
 
 
Top Targets:
SLC6sbd SERT(15)
 
 
SLC6sbd NET(14)
 
 
SLC6sbd DAT1(14)
 
 
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srx(7)
 
 
 
BioAssay Types:
Screening(181)
 
 
 
 
Literature(165)
 
 
 
 
 
Confirmatory(152)
 
 
 
 
 
BioActivity Types:
Potency(102)
 
 
 
 
 
IC50(63)
 
 
 
 
 
Ki(32)
 
 
 
EC50(9)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 427    Data Row: 509   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103343183]
Ki 0.000501Inhibition of SERT [AID431326, Type: Literature]
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2
[SID103343183]
Ki 0.0008Ability to inhibit the reuptake of 5-HT at human serotonin transporter [AID204085, Type: Literature]
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3
[SID103343183]
Ki 0.0008Binding affinity for 5-hydroxytryptamine transporter [AID238655, Type: Literature]
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4
[SID103343183]
Ki 0.003Displacement of [3H]nisoxetine from rat NET in rat cerebral cortex [AID537543, Type: Literature]Norepinephrine transporter [gi:81890335]
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5
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID103343183]
IC50 0.003Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103343183]
IC50 0.003Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103343183]
IC50 0.003Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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13
[SID103343183]
IC50 0.003Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
14
[SID103343183]
IC50 0.004Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells [AID423862, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103343183]
IC50 0.004Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells [AID423862, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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16
[SID103343183]
IC50 0.004Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cells [AID423862, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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17
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK cells [AID387487, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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18
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK cells [AID387487, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
View
19
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells [AID352215, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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20
[SID103343183]
IC50 0.004Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells [AID352215, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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21
[SID103343183]
IC50 0.004Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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22
[SID103343183]
IC50 0.004Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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23
[SID103343183]
Ki 0.0046Inhibition constant against serotonin transporter [AID254277, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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24
[SID103343183]
Ki 0.0046Inhibition constant against serotonin transporter [AID254277, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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25
[SID103343183]
Ki 0.0046Inhibition constant against serotonin transporter [AID254277, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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26
[SID103343183]
Ki 0.0046Inhibition of serotonin uptake into rat synaptosomes [AID187185, Type: Literature]
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27
[SID103343183]
Ki 0.0046Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometry [AID411215, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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28
[SID103343183]
Ki 0.005Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting [AID469543, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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29
[SID103343183]
Ki 0.005Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting [AID469543, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
30
[SID103343183]
Ki 0.005Displacement of [3H]5HT from human 5HT transporter expressed in HEK293 cells by scintillation counting [AID469543, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
31
[SID103343183]
Ki 0.005Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells [AID329322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
32
[SID103343183]
Ki 0.005Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells [AID329322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
33
[SID103343183]
Ki 0.005Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells [AID329322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
34
[SID103343183]
Ki 0.005Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay [AID484002, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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35
[SID103343183]
Ki 0.005Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay [AID484002, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
36
[SID103343183]
Ki 0.005Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay [AID484002, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
37
[SID103343183]
IC50 0.005Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells [AID423861, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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38
[SID103343183]
IC50 0.005Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells [AID423861, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
View
39
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cells [AID268714, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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40
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cells [AID268714, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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41
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cells [AID268714, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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42
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells [AID269937, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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43
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells [AID269937, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
44
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells [AID269937, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
45
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT from human SERT expressed in HEK293 cells [AID306267, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
46
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT from human SERT expressed in HEK293 cells [AID306267, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
47
[SID103343183]
IC50 0.006Inhibition of [3H]5-HT from human SERT expressed in HEK293 cells [AID306267, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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48
[SID103343183]
IC50 0.0066Inhibition of human SERT [AID321309, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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49
[SID103343183]
IC50 0.0066Inhibition of human SERT [AID321309, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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50
[SID103343183]
IC50 0.0066Inhibition of human SERT [AID321309, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View