Adenosine Monophosphate (CID 6083) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(38)
 
 
Top Targets:
FBPase(6)
 
 
GT1 Glycogen..(3)
 
 
ADA AMPD(1)
 
 
ADPGK ADPPFK(1)
 
 
RNase A canon..(1)
 
 
BioAssay Types:
Literature(31)
 
 
BioActivity Types:
IC50(11)
 
 
EC50(6)
 
 
Kd(6)
 
 
Ki(3)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 33    Data Row: 38   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103201463]
Ki 0.00023Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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2
[SID103201463]
Kd 0.00113Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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3
[SID103201463]
IC50 0.1Inhibition of p60c-src expressed in chick embryo fibroblast [AID358183, Type: other]
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4
[SID103201463]
IC50 0.14Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate [AID453457, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:311033495]
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5
[SID103201463]
IC50 0.3Inhibition of Rous sarcoma virus p60 v-src-induced IgG phosphorylation in tumor bearing rabbits by SDS PAGE [AID358182, Type: other]
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6
[SID103201463]
IC50 0.44Inhibition of FBPase in human liver [AID453456, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:311033495]
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7
[SID103201463]
IC50 0.8Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. [AID89523, Type: Literature]
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8
[SID103201463]
IC50 1Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry [AID354019, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:311033495]
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9
[SID103201463]
IC50 1Inhibition of rat FBPase [AID580981, Type: other]
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10
[SID103201463]
IC50 1.3Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry [AID419859, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:1706735]
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11
[SID103201463]
IC50 1.3Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay [AID477766, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:1706735]
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12
[SID103201463]
EC50 1.4Activation of rat GPPase [AID580980, Type: other]
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13
[SID103201463]
Kd 2.7Dissociation constant of the compound [AID238114, Type: Literature]
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14
[SID103201463]
EC50 3.5Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell [AID165253, Type: Literature]
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15
[SID103201463]
EC50 3.7Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell [AID150498, Type: Literature]
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16
[SID103201463]
Kd 5.4Displacement of [35S]APS from Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase by liquid scintillation counting [AID440580, Type: Literature]
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17
[SID103201463]
Kd 5.4Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in absence of MgCl2 [AID440581, Type: Literature]
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18
[SID103201463]
EC50 5.9Activation of human AMPK after 15 mins [AID580978, Type: other]
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19
[SID103201463]
EC50 7.2Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell [AID150332, Type: Literature]
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20
[SID103201463]
IC50 9.8Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay [AID477767, Type: Literature]Fructose-1,6-bisphosphatase 1 [gi:311033495]
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21
[SID103201463]
IC50 12.3Inhibition of human recombinant FBPase using fructose-1,6-biphosphate as substrate incubated for 3 mins prior to substrate addition by spectrophotometric analysis [AID684832, Type: other]
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22
[SID103201463]
Km 14Activity at ecto-5'-nucleotidase [AID448478, Type: Literature]
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23
[SID103201463]
EC50 17.25Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM [AID150488, Type: Literature]
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24
[SID103201463]
Kd 21Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in presence of 0.5 mM MgCl2 [AID440582, Type: Literature]
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25
[SID103201463]
Kd 31Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in presence of 2 mM MgCl2 [AID440583, Type: Literature]
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26
[SID103201463]
Km 32.8Activity of recombinant human ADAL1 expressed in Escherichia coli by UV-spectrophotometry [AID612651, Type: Literature]Adenosine deaminase-like protei [gi:146286026]
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27
[SID103201463]
Ki 38Inhibition constant was evaluated against horse liver alcohol dehydrogenase [AID33710, Type: Literature]
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28
[SID103201463]
 Tested for relaxation of carbachol-contracted guinea pig taenia coli at 37 degree C; Significantly less potent than ATP [AID77361, Type: Literature]
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29
[SID48415520]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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30
[SID103201463]
 Measure of Agonist Potency at human P2Y purinoceptor 4 (hP2Y4) stably expressed in 131N1 astrocytoma cell; Antagonist effect [AID150626, Type: Literature]
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31
[SID103201463]
Ki Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 5.5 by single turnover method in absence of thioredoxin [AID440574, Type: Literature]
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32
[SID103201463]
 Inhibition of Escherichia coli KPR at 1 mM [AID269131, Type: Literature]
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33
[SID46392931]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structural Basis For The Activation Of Glycogen Phosphorylase B By Adenosine Monophosphate [gi:494494]
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34
[SID46393301]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of An Adp-Dependent Glucokinase From Pyrococcus Furiosus [gi:46015797]
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35
[SID46393711]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Ribonuclease A- Amp Complex [gi:75765679]
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36
[SID46394204]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Xac Nucleotide Pyrophosphatase/phosphodiesterase In Complex With Amp [gi:112490889]
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37
[SID46394436]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structural Mechanism For Glycogen Phosphorylase Control By Phosphorylation And Amp [gi:231257]
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38
[SID46394446]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structural Mechanism For Glycogen Phosphorylase Control By Phosphorylation And Amp [gi:157837173]
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