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Methoxamine (CID 6082) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(66)
 
 
Inconclusive(5)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
Hexokinase 2(3)
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(68)
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(67)
 
 
 
IC50(3)
 
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 79    Data Row: 86   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174599]
EC50 0.72Alpha-1 adrenergic receptor activation causing vasoconstriction in the isolated rabbit ear artery [AID36262, Type: Literature]
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2
[SID103174599]
EC50 0.72Alpha-1 adrenergic receptor agonist activity in rabbit ear artery [AID36419, Type: Literature]
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3
[SID103174599]
IC50 3.650% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes [AID36783, Type: Literature]
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4
[SID103174599]
Phentolamine dissociation constant was evaluated in rabbit ear artery [AID166802, Type: Literature]
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5
[SID85209476]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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6
[SID103174599]
Dissociation constant for Alpha-1-adrenergic receptor was determined before and after addition of phentolamine [AID36273, Type: Literature]
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7
[SID48416249]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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8
[SID103174599]
IC50 170Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membranes by 50% was reported. [AID36715, Type: Literature]
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9
[SID103174599]
Approximate efficacy based on maximal effect produced by methoxamine was determined against the alpha-2 adrenergic receptor [AID36658, Type: Literature]
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10
[SID103174599]
Tested for Alpha adrenergic receptor agonistic activity on isolated rat vas deferens [AID33265, Type: Literature]
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11
[SID103174599]
Tested for Alpha adrenergic receptor agonistic activity on isolated rat vas deferens [AID33267, Type: Literature]
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12
[SID103174599]
Evaluated for alpha-2 adrenergic receptor activity in the field stimulated rat vas deferens preparation [AID35490, Type: Literature]
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13
[SID103174599]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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14
[SID103174599]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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15
[SID103174599]
Hypertensive activity (increase in arterial pressure to 60 mmHg)) after i.v. administration to pithed rats. [AID197169, Type: Literature]
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16
[SID90341132]
Potency 0.7079qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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17
[SID90341132]
Potency 22.3872qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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18
[SID49698962]
High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1332, Type: confirmatory]
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19
[SID90341132]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID49698962]
IC50 Vibrio cholerae assay for pro-quorum sensing small molecules [AID686977, Type: confirmatory]cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657203]
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