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Methoxamine (CID 6082) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(65)
 
 
Inconclusive(5)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
Hexokinase 2(3)
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
Literature(14)
 
 
 
 
BioActivity Types:
Potency(66)
 
 
 
IC50(3)
 
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 76    Data Row: 83   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174599]
EC50 0.72Alpha-1 adrenergic receptor activation causing vasoconstriction in the isolated rabbit ear artery [AID36262, Type: Literature]
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2
[SID103174599]
EC50 0.72Alpha-1 adrenergic receptor agonist activity in rabbit ear artery [AID36419, Type: Literature]
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3
[SID103174599]
IC50 3.650% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes [AID36783, Type: Literature]
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4
[SID103174599]
Phentolamine dissociation constant was evaluated in rabbit ear artery [AID166802, Type: Literature]
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5
[SID48416249]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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6
[SID85209476]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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7
[SID103174599]
Dissociation constant for Alpha-1-adrenergic receptor was determined before and after addition of phentolamine [AID36273, Type: Literature]
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8
[SID103174599]
IC50 170Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membranes by 50% was reported. [AID36715, Type: Literature]
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9
[SID103174599]
Approximate efficacy based on maximal effect produced by methoxamine was determined against the alpha-2 adrenergic receptor [AID36658, Type: Literature]
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10
[SID103174599]
Tested for Alpha adrenergic receptor agonistic activity on isolated rat vas deferens [AID33265, Type: Literature]
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11
[SID103174599]
Tested for Alpha adrenergic receptor agonistic activity on isolated rat vas deferens [AID33267, Type: Literature]
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12
[SID103174599]
Evaluated for alpha-2 adrenergic receptor activity in the field stimulated rat vas deferens preparation [AID35490, Type: Literature]
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13
[SID103174599]
Hypertensive activity (increase in arterial pressure to 60 mmHg)) after i.v. administration to pithed rats. [AID197169, Type: Literature]
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14
[SID90341132]
Potency 0.7079qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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15
[SID90341132]
Potency 22.3872qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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16
[SID90341132]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID90341132]
Potency qHTS for Inhibitors of ATXN expression: Validation [AID588378, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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18
[SID90341132]
Potency qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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19
[SID90341132]
Potency qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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20
[SID90341132]
Potency qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463106, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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21
[SID90341132]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: ADP-Glo assay [AID743206, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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22
[SID90341132]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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23
[SID90341132]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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24
[SID90341132]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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25
[SID90341132]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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26
[SID90341132]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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27
[SID90341132]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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28
[SID90341132]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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29
[SID49698962]
IC50 Vibrio cholerae assay for pro-quorum sensing small molecules [AID686977, Type: confirmatory]cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657203]
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30
[SID90341132]
Potency qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 [AID488837, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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31
[SID90341132]
Potency qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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32
[SID90341132]
Potency qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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33
[SID90341132]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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34
[SID90341132]
Potency qHTS of Trypanosoma Brucei Inhibitors: LOPAC Validation [AID624147, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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35
[SID90341132]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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36
[SID90341132]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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37
[SID90341132]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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38
[SID90341132]
Potency Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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39
[SID90341132]
Potency Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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40
[SID90341132]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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41
[SID90341132]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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42
[SID90341132]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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43
[SID90341132]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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44
[SID90341132]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Mutase [AID504548, Type: confirmatory]2,3-bisphosphoglycerate-independent phosphoglycerate mutase [Leishmania major strain Friedlin] [gi:157877932]
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45
[SID90341132]
Potency Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation [AID504836, Type: Literature]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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46
[SID49698962]
High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1332, Type: confirmatory]
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47
[SID90341132]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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48
[SID90341132]
Potency qHTS Validation Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID485345, Type: confirmatory]
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49
[SID90341132]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory] [geneid:4780]
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50
[SID90341132]
Potency qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: LOPAC Validation Assay [AID720559, Type: confirmatory]Amyloid beta A4 protein [gi:112927]
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