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aripiprazole (CID 60795) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(122)
 
 
Inactive(750)
 
 
Inconclusive(99)
 
 
Unspecified(109)
 
 
Top Targets:
7TM GPCR Srsx(60)
 
 
 
 
7TM GPCR Srx(55)
 
 
 
 
NR LBD PPAR(14)
 
 
 
 
Bcl-2 like(11)
 
 
G-alpha(10)
 
 
 
 
BioAssay Types:
Screening(468)
 
 
 
 
Confirmatory(314)
 
 
 
 
 
Literature(240)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(270)
 
 
 
 
 
IC50(51)
 
 
 
 
 
Ki(47)
 
 
 
 
EC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 887    Data Row: 1080   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103307946]
Ki 0.0002Displacement of [3H]raclopride from human D2 dopamine receptor expressed in CHO cell membranes [AID727075, Type: Literature]D(2) dopamine receptor [gi:118206]
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2
[SID103307946]
Ki 0.0004Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate [AID457688, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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3
[SID103307946]
Ki 0.0008Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr [AID723179, Type: Literature]D(2) dopamine receptor [gi:118206]
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4
[SID103307946]
Ki 0.0008Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID492643, Type: Literature]D(1A) dopamine receptor [gi:118229]
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5
[SID103307946]
Ki 0.0008Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID410332, Type: Literature]D(2) dopamine receptor [gi:47117674]
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6
[SID103307946]
Ki 0.0008Binding affinity to 5-HT2A [AID616781, Type: Literature]
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7
[SID103307946]
Ki 0.001Displacement of [3H]nemonapride from D2-like receptor in Wistar rat striatum homogenate [AID457687, Type: Literature]
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8
[SID103307946]
EC50 0.001Agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated cAMP production by luminescence assay [AID698937, Type: Literature]D(2) dopamine receptor [gi:118206]
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9
[SID103307946]
Ki 0.0018Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cells [AID595495, Type: Literature]D(2) dopamine receptor [gi:118206]
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10
[SID103307946]
Ki 0.0026Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells [AID458632, Type: Literature]D(2) dopamine receptor [gi:118206]
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11
[SID103307946]
Ki 0.0028Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells [AID458633, Type: Literature]D(2) dopamine receptor [gi:118206]
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12
[SID103307946]
Ki 0.0031Displacement of [125I]ABN from human recombinant D2L receptor expressed in HEK cells after 60 mins by gamma counter [AID610678, Type: Literature]D(2) dopamine receptor [gi:118206]
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13
[SID103307946]
Ki 0.0033Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID492642, Type: Literature]D(2) dopamine receptor [gi:47117674]
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14
[SID103307946]
Ki 0.0033Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometry [AID410333, Type: Literature]
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15
[SID103307946]
Ki 0.0039Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting method [AID698938, Type: Literature]D(2) dopamine receptor [gi:118206]
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16
[SID103307946]
Ki 0.004Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cells [AID516804, Type: Literature]D(2) dopamine receptor [gi:118206]
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17
[SID103307946]
EC50 0.004Agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assay [AID698935, Type: Literature]D(2) dopamine receptor [gi:118206]
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18
[SID103307946]
Ki 0.004Binding affinity to human 5HT2A receptor [AID516805, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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19
[SID103307946]
Ki 0.0056Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 after 1 hr [AID723184, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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20
[SID103307946]
Ki 0.0056Displacement of [3H]8OH-DPAT from 5HT1A receptor in rat CRL:CD(SD)BR-COBS hippocampus by scintillation spectrometry [AID492641, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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21
[SID103307946]
Ki 0.0056Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometry [AID410334, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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22
[SID103307946]
Ki 0.0068Displacement of [125I]ABN from human recombinant D3 receptor expressed in HEK cells after 60 mins by gamma counter [AID610679, Type: Literature]D(3) dopamine receptor [gi:1169206]
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23
[SID103307946]
Ki 0.007Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate [AID457689, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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24
[SID103307946]
Ki 0.007Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells [AID516806, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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25
[SID103307946]
IC50 0.0076Antagonist activity at human D2 dopamine receptor expressed in CHO cell membrane by GTPgammaS-binding assay [AID727074, Type: Literature]D(2) dopamine receptor [gi:118206]
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26
[SID103307946]
Ki 0.0087Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry [AID492640, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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27
[SID103307946]
Ki 0.0087Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry [AID410335, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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28
[SID103307946]
Ki 0.0096Binding affinity to human 5HT2A receptor [AID595497, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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29
[SID103307946]
Ki 0.0097Displacement of [3H]-methylspiperone from human dopamine D3 receptor expressed in HEK293 after 1 hr [AID722917, Type: Literature]D(3) dopamine receptor [gi:1169206]
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30
[SID103307946]
Ki 0.0103Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells [AID595498, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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31
[SID103307946]
Ki 0.014Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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32
[SID103307946]
Ki 0.021Displacement of [3H]-ketanserin from human 5HT2A receptor expressed in HEK293 after 1.5 hrs [AID723183, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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33
[SID103307946]
Ki 0.022Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells [AID599883, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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34
[SID103307946]
Ki 0.022Displacement of [3H]mesulergine from 5HT2C receptor in CRL:(HA) BR albino guinea pig cortex by scintillation spectrometry [AID410336, Type: Literature]
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35
[SID103307946]
Ki 0.022Displacement of [3H]mesulergine from 5HT2C receptor in CRL:(HA) BR albino guinea pig cortex by scintillation spectrometry [AID492639, Type: Literature]
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36
[SID103307946]
Ki 0.0257Displacement of [3H]-Prazosin from adrenergic alpha1 receptor in rat cortex after 30 mins by scintillation counting [AID723177, Type: Literature]
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37
[SID103307946]
Ki 0.026Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr [AID723182, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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38
[SID103307946]
Ki 0.09Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 after 1 hr [AID723181, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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39
[SID103307946]
Ki 0.098Binding affinity to SERT [AID616780, Type: Literature]
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40
[SID103307946]
Ki 0.168Displacement of [125I]ABN from human recombinant D4 receptor expressed in HEK cells after 60 mins by gamma counter [AID610680, Type: Literature]D(4) dopamine receptor [gi:1345939]
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41
[SID103307946]
Ki 0.574Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells [AID599884, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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42
[SID103307946]
Ki 0.598Displacement of [3H]dofetilide from human ERG [AID516803, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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43
[SID103307946]
IC50 0.63096Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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44
[SID103307946]
IC50 0.78Inhibition of human ABCB1-mediated rhodamine 123 efflux in mouse L5178 cells expressing human MDR1 after 20 mins by FACS analysis [AID598251, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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45
[SID103307946]
IC50 1Inhibition of human ERG [AID539465, Type: Literature]
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46
[SID103307946]
Ki 1.02Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clamp method [AID410338, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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47
[SID103307946]
Ki 1.02Binding affinity to human ERG expressed in HEK293 cells [AID492638, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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48
[SID103307946]
Ki 1.08Displacement of [3H]-citalopram from SERT in rat cerebral cortex after 1 hr by scintillation counting [AID723175, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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49
[SID103307946]
Ki 1.96Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID410331, Type: Literature]D(1A) dopamine receptor [gi:118229]
View
50
[SID144205281]
Potency-Replicate_1 5.308qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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