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aripiprazole (CID 60795) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(121)
 
 
Inactive(762)
 
 
Inconclusive(97)
 
 
Unspecified(112)
 
 
Top Targets:
7TM GPCR Srsx(60)
 
 
 
 
7TM GPCR Srx(55)
 
 
 
 
NR LBD PPAR(14)
 
 
 
Bcl-2 like(11)
 
 
G-alpha(10)
 
 
 
 
BioAssay Types:
Screening(469)
 
 
 
 
Confirmatory(315)
 
 
 
 
 
Literature(250)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(271)
 
 
 
 
 
IC50(51)
 
 
 
 
 
Ki(47)
 
 
 
 
EC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 892    Data Row: 1092   Total Pages: 55   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103307946]
Ki 0.0002Displacement of [3H]raclopride from human D2 dopamine receptor expressed in CHO cell membranes [AID727075, Type: Literature]D(2) dopamine receptor [gi:118206]
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2
[SID103307946]
Ki 0.0004Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate [AID457688, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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3
[SID103307946]
Ki 0.0008Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr [AID723179, Type: Literature]D(2) dopamine receptor [gi:118206]
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4
[SID103307946]
Ki 0.0008Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID492643, Type: Literature]D(1A) dopamine receptor [gi:118229]
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5
[SID103307946]
Ki 0.0008Binding affinity to 5-HT2A [AID616781, Type: Literature]
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6
[SID103307946]
Ki 0.0008Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID410332, Type: Literature]D(2) dopamine receptor [gi:47117674]
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7
[SID103307946]
Ki 0.001Displacement of [3H]nemonapride from D2-like receptor in Wistar rat striatum homogenate [AID457687, Type: Literature]
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8
[SID103307946]
EC50 0.001Agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated cAMP production by luminescence assay [AID698937, Type: Literature]D(2) dopamine receptor [gi:118206]
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9
[SID103307946]
Ki 0.0018Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cells [AID595495, Type: Literature]D(2) dopamine receptor [gi:118206]
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10
[SID103307946]
Ki 0.0026Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells [AID458632, Type: Literature]D(2) dopamine receptor [gi:118206]
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11
[SID103307946]
Ki 0.0028Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells [AID458633, Type: Literature]D(2) dopamine receptor [gi:118206]
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12
[SID103307946]
Ki 0.0031Displacement of [125I]ABN from human recombinant D2L receptor expressed in HEK cells after 60 mins by gamma counter [AID610678, Type: Literature]D(2) dopamine receptor [gi:118206]
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13
[SID103307946]
Ki 0.0033Displacement of [3H]7OH-DPAT from dopamine D3 receptor expressed in Sf9 cells by scintillation spectrometry [AID410333, Type: Literature]
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14
[SID103307946]
Ki 0.0033Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry [AID492642, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
15
[SID103307946]
Ki 0.0039Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting method [AID698938, Type: Literature]D(2) dopamine receptor [gi:118206]
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16
[SID103307946]
Ki 0.004Displacement of [3H]-Spiperone from human dopamine D2L receptor expressed in CHO cells [AID516804, Type: Literature]D(2) dopamine receptor [gi:118206]
View
17
[SID103307946]
Ki 0.004Binding affinity to human 5HT2A receptor [AID516805, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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18
[SID103307946]
EC50 0.004Agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assay [AID698935, Type: Literature]D(2) dopamine receptor [gi:118206]
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19
[SID103307946]
Ki 0.0056Displacement of [3H]8OH-DPAT from 5HT1A receptor in rat CRL:CD(SD)BR-COBS hippocampus by scintillation spectrometry [AID492641, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
View
20
[SID103307946]
Ki 0.0056Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometry [AID410334, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
View