Cyclic AMP (CID 6076) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(124)
 
 
Inconclusive(17)
 
 
Unspecified(35)
 
 
Top Targets:
ABCC MRP doma..(6)
 
 
Pyr redox dim(5)
 
 
HELICc(4)
 
 
 
7TM GPCR Srx(4)
 
 
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(125)
 
 
 
 
 
Literature(36)
 
 
 
 
Screening(12)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(125)
 
 
 
 
 
EC50(1)
 
 
IC50(1)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 183    Data Row: 189   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103317043]
Km 0.05Inhibition of Phosphodiesterase 8 [AID158285, Type: Literature]CAMP-specific cyclic nucleotide phosphodiesterase PDE8 [gi:81864950]
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2
[SID103317043]
Km 0.2Inhibition of Phosphodiesterase 7 [AID158280, Type: Literature]
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3
[SID90340992]
Potency 0.3663HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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4
[SID90340992]
Potency 0.3663HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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5
[SID90340992]
Potency 0.3663HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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6
[SID90340992]
Potency 0.3663HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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7
[SID103317043]
Km 0.53Affinity for bovine heart phosphodiesterase [AID158420, Type: Literature]
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8
[SID103317043]
Km 0.56Affinity for rabbit lung phosphodiesterase [AID158735, Type: Literature]
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9
[SID103317043]
Km 0.56Inhibition of rabbit lung cAMP Phosphodiesterase [AID219819, Type: Literature]
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10
[SID103317043]
Km 0.79Affinity for rabbit kidney phosphodiesterase [AID158734, Type: Literature]
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11
[SID103317043]
Km 1.3Inhibition of bovine brain cAMP Phosphodiesterase [AID219691, Type: Literature]
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12
[SID50105813]
Potency 2.8184qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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13
[SID103317043]
IC50 48Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis [AID663168, Type: Literature]
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14
[SID103317043]
 Activation of olfactory CNG A2A41b channel expressed in HEK293 cells assessed as effect on half maximal current [AID297178, Type: Literature]
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15
[SID103317043]
 Activity of bovine aortic PDE4 [AID628762, Type: Literature]
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16
[SID17404647]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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17
[SID17404647]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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18
[SID103317043]
EC50 1GRAC: human CNGA2 activator [AID540671, Type: other]Cyclic nucleotide-gated olfactory channel [gi:119370323]
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19
[SID103317043]
Km 44.5TP_TRANSPORTER: uptake in membrane vesicles from MRP4-expressing Sf9 cells [AID679496, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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20
[SID103317043]
Km 150Inhibition of Phosphodiesterase 5 [AID158111, Type: Literature]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:5921804]
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21
[SID103317043]
Km 379TP_TRANSPORTER: uptake in membrane vesicles from MRP5-expressing V79 cells [AID680352, Type: other]Multidrug resistance-associated protein 5 [gi:8928547]
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22
[SID103317043]
Ki 780Inhibition constant was evaluated against horse liver alcohol dehydrogenase [AID33710, Type: Literature]
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23
[SID103317043]
ED50 5000Antiviral activity against Herpes simplex virus -2 strain MS was evaluated in african green monkey kidney [AID84938, Type: Literature]
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24
[SID103317043]
ED50 5000Antiviral activity against Vaccinia virus strain Elstree was evaluated in african green monkey kidney [AID217820, Type: Literature]
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25
[SID103317043]
ED50 5000Antiviral activity against Herpes simplex virus -1 strain KOS was evaluated in african green monkey kidney [AID86027, Type: Literature]
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26
[SID103317043]
ED50 5000Antiviral activity against Para influenza virus type 3 strain C243 was evaluated in african green monkey kidney [AID155571, Type: Literature]
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27
[SID103317043]
 In vitro antiviral activity against Para influenza virus type 3 strain C243 was evaluated in african green monkey kidney [AID155572, Type: Literature]
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28
[SID103317043]
 Percent inhibition against L1210 cell line in mice. [AID97751, Type: Literature]
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29
[SID103317043]
 Percent inhibition against P388 cell line in mice. [AID154165, Type: Literature]
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30
[SID103317043]
 Compound was evaluated for activation of bovine heart protein kinase. [AID164454, Type: Literature]
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31
[SID103317043]
 In vitro antiviral activity against Vaccinia virus strain Elstree was evaluated in african green monkey kidney [AID217969, Type: Literature]
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32
[SID103317043]
 Inhibition of bovine heart cAMP Phosphodiesterase [AID219685, Type: Literature]
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33
[SID103317043]
 Activate a partially purified type II cAMP-dependent protein kinase from bovine brain [AID219827, Type: Literature]
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34
[SID103317043]
 Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney [AID219982, Type: Literature]
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35
[SID103317043]
 Activation of cAMP-dependent protein kinase type I [AID220152, Type: Literature]
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36
[SID103317043]
 Specificity for protein kinase-I and protein kinase-II [AID220153, Type: Literature]
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37
[SID103317043]
 In vitro antiviral activity against Herpes simplex virus -2 strain MS was evaluated in african green monkey kidney [AID85090, Type: Literature]
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38
[SID103317043]
 In vitro antiviral activity against Herpes simplex virus -1 strain KOS was evaluated in african green monkey kidney [AID84060, Type: Literature]
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39
[SID103317043]
 Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis relative to cAMP [AID663169, Type: Literature]
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40
[SID103317043]
 TP_TRANSPORTER: inhibition of cGMP uptake (cGMP: 5 uM, cAMP: 500 uM) in membrane vesicles from MRP5-expressing V79 cells [AID681864, Type: other]Multidrug resistance-associated protein 5 [gi:8928547]
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41
[SID103317043]
 Substrates of transporters of clinical importance in the absorption and dispostion of drugs, MRP4 [AID588979, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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42
[SID103317043]
 TP_TRANSPORTER: inhibition of cGMP uptake (cGAMP: 1 uM, cAMP: 250 uM) in membrane vesicles from MRP4-expressing Sf9 cells [AID681878, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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43
[SID103317043]
 TP_TRANSPORTER: inhibition of MTX uptake (MTX: 20 uM, cAMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells [AID681905, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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44
[SID103317043]
 TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 1 uM, cAMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells [AID681923, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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45
[SID103317043]
 TP_TRANSPORTER: efflux in MRP4-expressing HepG2 cells [AID682097, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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46
[SID103317043]
 TP_TRANSPORTER: uptake in OAT2-expressing EcR293 cells [AID678961, Type: other]Solute carrier family 22 member 7 [gi:74753520]
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47
[SID50105813]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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48
[SID103317043]
 Activation of cAMP-dependent protein kinase type II [AID220154, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125209]
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49
[SID103317043]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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50
[SID103317043]
 TP_TRANSPORTER: efflux in MRP8-1-expressing LLC-PK1 cells [AID679657, Type: other]ATP-binding cassette sub-family C member 11 [gi:74762666]
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