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Folic Acid (CID 6037) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(838)
 
 
Inconclusive(75)
 
 
Unspecified(77)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD PPAR(16)
 
 
 
p450(15)
 
 
NR LBD ER(14)
 
 
 
 
BioAssay Types:
Confirmatory(445)
 
 
 
 
 
Screening(368)
 
 
 
 
Literature(67)
 
 
 
 
Summary(48)
 
 
 
BioActivity Types:
Potency(413)
 
 
 
 
 
IC50(34)
 
 
 
EC50(9)
 
 
Kd(4)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 787    Data Row: 1012   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103604564]
Kd 0.001Dissociation constant against folic acid receptor (FAR); Value ranges from 0.1-1 nM [AID238138, Type: Literature]
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2
[SID103604564]
Kd 0.81Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57251, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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3
[SID103604564]
Kd 4.4Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57256, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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4
[SID103604564]
Kd 4.8Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57262, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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5
[SID103604564]
Ki 8.95Tested for inhibition of [14C]-DDATHF influx in CEM/MTX cells of human leukemic lymphoblasts [AID46774, Type: Literature]
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6
[SID11112150]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID11112150]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID144205112]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID26754169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID26754169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID144210447]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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12
[SID144210447]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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13
[SID103604564]
Ki 40Inhibitory constant of thymidylate synthase was determined in human AML cells [AID212457, Type: Literature]
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14
[SID144210447]
Potency-Replicate_1 44.6684qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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15
[SID50085945]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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16
[SID11112150]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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17
[SID11112150]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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18
[SID48416033]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID50085945]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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20
[SID50085945]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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21
[SID50085945]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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22
[SID46394037]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Methionine-Free Mutant Of Escherichia Coli Dihydrofolate Reductase [gi:90109160]
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23
[SID11112150]
Potency 7.9433qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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24
[SID103604564]
Ki 14.1TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cells [AID681604, Type: other]Solute carrier organic anion transporter family member 1A3 [gi:27735248]
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25
[SID103604564]
Km 93Maximum rate of metabolism for hog liver folyl-poly-glutamate synthetase was evaluated [AID18279, Type: Literature]
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26
[SID103604564]
IC50 100Compound was evaluated for inhibition of MTX influx into MOLT-4 cells [AID105505, Type: Literature]
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27
[SID103604564]
Km 104.6Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase [AID71218, Type: Literature]
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28
[SID103604564]
Ki 167Tested for the inhibition of [14C]-DDATHF influx in CCRF-CEM cells of human leukemic lymphoblast [AID43856, Type: Literature]
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29
[SID103604564]
Km 170TP_TRANSPORTER: uptake in membrane vesicles from MRP4-expressing Sf9 cells [AID680355, Type: other]Multidrug resistance-associated protein 4 [gi:206729914]
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30
[SID103604564]
IC50 180Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cells [AID212636, Type: Literature]
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31
[SID103604564]
IC50 290Ability to inhibit thymidylate synthase derived from human leukemia K562 cells [AID212156, Type: Literature]
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32
[SID103604564]
IC50 1000Inhibitory activity against thymidylate synthase in the intact L1210 cells [AID213840, Type: Literature]
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33
[SID103604564]
Km 1960TP_TRANSPORTER: uptake in membrane vesicles from MRP3-expressing HEK293 cells [AID679299, Type: other]Multidrug resistance associated protein [gi:74761045]
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34
[SID103604564]
IC50 10000Inhibitory activity against growth of L1210 leukemia cells in culture [AID101080, Type: Literature]
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35
[SID103604564]
Km 2.34e+08Activity (apparent Km ) was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . [AID71200, Type: Literature]
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36
[SID103604564]
Activity (relative Km ) was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . [AID71201, Type: Literature]
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37
[SID103604564]
Activity (relative Vmax) was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . [AID71205, Type: Literature]
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38
[SID103604564]
Inhibitory activity against growth of L1210 leukemia cells in culture [AID101223, Type: Literature]
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39
[SID103604564]
Inhibitory activity against growth of L1210 leukemia cells in culture at 0.5 mM; No significant inhibition [AID101225, Type: Literature]
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40
[SID103604564]
It is the ratio of apparent kinetic constant to that of relative maximum velocity [AID230430, Type: Literature]
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41
[SID103604564]
Ratio of relative Vmax to that of Km values. [AID230505, Type: Literature]
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42
[SID103604564]
Ratio between Ki values of CCRF-CEM and CEM/MTX [AID231680, Type: Literature]
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43
[SID103604564]
Concentration required to completely block the uptake of either G5-FI-FA or G5-FI-FA-MTX dendrimer (30 nM) in FAR expressing KB cells [AID252410, Type: Literature]
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44
[SID103604564]
Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 uM aminopterin) [AID71229, Type: Literature]
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45
[SID103604564]
Apparent catalytic rate folyl-poly-glutamate synthetase [AID71385, Type: Literature]
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46
[SID103604564]
Catalytic rate folyl-poly-glutamate synthetase [AID71492, Type: Literature]
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47
[SID103604564]
First order catalytic rate folyl-poly-glutamate synthetase [AID71494, Type: Literature]
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48
[SID103604564]
Compound was tested for release of tritium from 1 uM [5-3H]-dUMP into water at a con of 0.4 mM and without addition of bovine thymidylate synthase to cell suspension in absence of CH2O [AID99303, Type: Literature]
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49
[SID103604564]
Compound was tested for release of tritium from 1 uM [5-3H]-dUMP into water at a con of 0.4 mM and without addition of bovine thymidylate synthase to cell suspension in absence of serine [AID99304, Type: Literature]
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50
[SID103604564]
Compound was tested for release of tritium from 1 uM [5-3H]-dUMP into water at a conc of 0.4 mM enzyme(bovine thymidylate synthase) was added to cell suspension in presence of CH2O [AID99305, Type: Literature]
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