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Folic Acid (CID 6037) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(852)
 
 
Inconclusive(69)
 
 
Unspecified(81)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD PPAR(16)
 
 
 
p450(15)
 
 
NR LBD ER(14)
 
 
 
 
BioAssay Types:
Confirmatory(446)
 
 
 
 
 
Screening(369)
 
 
 
 
Literature(95)
 
 
 
 
Summary(48)
 
 
 
BioActivity Types:
Potency(414)
 
 
 
 
 
IC50(35)
 
 
 
 
EC50(9)
 
 
Kd(6)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 798    Data Row: 1030   Total Pages: 52   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103604564]
Kd 0.001Dissociation constant against folic acid receptor (FAR); Value ranges from 0.1-1 nM [AID238138, Type: Literature]
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2
[SID103604564]
IC50 0.5Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay [AID1053335, Type: Literature]
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3
[SID103604564]
Kd 0.81Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57251, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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4
[SID103604564]
Kd 4.4Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57256, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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5
[SID103604564]
Kd 4.8Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 [AID57262, Type: Literature]dihydrofolate reductase [Escherichia coli] [gi:165971782]
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6
[SID103604564]
Ki 8.95Tested for inhibition of [14C]-DDATHF influx in CEM/MTX cells of human leukemic lymphoblasts [AID46774, Type: Literature]
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7
[SID46394037]
Kd 9.51Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Methionine-Free Mutant Of Escherichia Coli Dihydrofolate Reductase [gi:90109160]
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8
[SID46394037]
Kd 9.51Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Methionine-Free Mutant Of Escherichia Coli Dihydrofolate Reductase [gi:90109160]
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9
[SID11112150]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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10
[SID11112150]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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11
[SID144205112]
Potency-Replicate_1 21.1317qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID26754169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID26754169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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14
[SID144210447]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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15
[SID144210447]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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16
[SID103604564]
Ki 40Inhibitory constant of thymidylate synthase was determined in human AML cells [AID212457, Type: Literature]
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17
[SID144210447]
Potency-Replicate_1 44.6684qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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18
[SID50085945]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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19
[SID11112150]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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20
[SID11112150]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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