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BioActivity Data for Compound AGN-PC-0DB7R9 (CID 60196366)

BioActivity Outcomes:
Active(14)
 
 
Inactive(43)
 
 
Inconclusive(14)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
 
NR LBD GR(4)
 
 
 
NR LBD TR(3)
 
 
 
7tm 4(2)
 
 
BioAssay Types:
Confirmatory(49)
 
 
 
 
Summary(15)
 
 
 
 
Literature(9)
 
 
 
 
Screening(2)
 
 
BioAssay Categories:
Toxicity(7)
 
 
 
ADME(1)
 
 
Cell-based(4)
 
 
 
BioActivity Types:
Potency(62)
 
 
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 75    Data Row: 75   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID242573879]
IC50 0.016Antiprotozoal activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes by [3H]hypoxanthine uptake [AID418750, Type: Literature]
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2
[SID242573879]
IC50 0.019Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes after 70 hrs by alamar blue assay [AID418748, Type: Literature]
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3
[SID242573879]
IC50 1.17Antiprotozoal activity against Leishmania donovani MHOM/SD/62/1S-CL2D axenic amastigotes after 72 hrs [AID418752, Type: Literature]
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4
[SID144207153]
Potency 3.7586qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID144207153]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID144207153]
Potency-Replicate_1 5.9557qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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7
[SID242573879]
IC50 6.4Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay [AID418747, Type: Literature]
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8
[SID144207153]
Potency-Replicate_1 6.6824qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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9
[SID144207153]
Potency 7.0795qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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10
[SID144207153]
Potency-Replicate_1 8.4127qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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11
[SID144207153]
Ratio Potency (uM) 18.9959qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID144207153]
Potency-Replicate_1 21.3138qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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13
[SID144207153]
Ratio Potency (uM) 22.5767qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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14
[SID144207153]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
15
[SID242573879]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 trypomastigotes [AID418749, Type: Literature]
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16
[SID242573879]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Leishmania donovani MHOM/SD/62/1S-CL2D axenic amastigotes [AID418753, Type: Literature]
View
17
[SID242573879]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1 [AID418751, Type: Literature]
View
18
[SID242573879]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes infected in NMRI mouse assessed as mouse survival at 5 mg/kg, ip administered from day 3 to day 6 postinfection [AID418764, Type: Literature]
View
19
[SID144207153]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
20
[SID144207153]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View