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BioActivity Data for Compound DSSTox_CID_26492 (CID 60196290)

BioActivity Outcomes:
Active(48)
 
 
Inactive(58)
 
 
Inconclusive(40)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
NR LBD Fxr(4)
 
 
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Confirmatory(104)
 
 
 
 
Summary(27)
 
 
 
 
Screening(15)
 
 
 
BioAssay Categories:
Toxicity(6)
 
 
 
 
Cell-based(21)
 
 
 
BioActivity Types:
Potency(96)
 
 
 
 
AC50(21)
 
 
 
IC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 146    Data Row: 146   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170465289]
IC50 0.0254VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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2
[SID170465289]
AC50 (uM) 0.7079qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 ratio channel [AID1117305, Type: confirmatory]
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3
[SID170465289]
AC50 (uM) 1qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 blue channel [AID1117304, Type: confirmatory]
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4
[SID170465289]
IC50 1.2784Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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5
[SID170465289]
Antagonist Potency (uM) 1.33332qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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6
[SID170465289]
Ac50 1.5342qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen 3, ratio channel [AID1117313, Type: confirmatory]
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7
[SID170465289]
AC50 (uM) 2.1671qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 3 ratio channel [AID1117300, Type: confirmatory]
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8
[SID144205802]
Ratio Potency (uM) 2.39145qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID170465289]
AC50 (uM) 3.0611qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 3 blue channel [AID1117306, Type: confirmatory]
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10
[SID170465289]
Ac50 3.16228qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen1, ratio channel [AID1117318, Type: confirmatory]
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11
[SID170465289]
AC50 (uM) 3.17qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 1 ratio channel [AID1117303, Type: confirmatory]
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12
[SID170465289]
AC50 (uM) 3.5481qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 1 blue channel [AID1117301, Type: confirmatory]
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13
[SID144205802]
Potency 3.7586qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144205802]
Potency-Replicate_1 3.7902qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID170465289]
IC50 3.8121Increased chromatin condensation in HeLa cells-IC50 [AID1117350, Type: confirmatory]
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16
[SID144205802]
Potency 4.2172qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID170465289]
Potency-Replicate_1 4.7304qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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18
[SID144205802]
Potency-Replicate_1 5.9557qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID144205802]
Potency-Replicate_1 7.4978qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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20
[SID170465289]
Potency-Replicate_1 7.5624qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway - cell viability counter screen [AID1159517, Type: confirmatory]
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