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SMR000308205 (CID 6018993) - Compound BioActivity Data
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BioActivity Outcomes:
Active(96)
 
 
Inactive(515)
 
 
Inconclusive(32)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(16)
 
 
 
RGS RGS4(9)
 
 
 
Bcl-2 like(8)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(397)
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(47)
 
 
 
 
EC50(15)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 586    Data Row: 646   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104245542]
IC50 0.03DNDI: Inhibition of Human African Trypanosomiasis (HAT), STIB 795, in vitro [AID685529, Type: other]
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2
[SID104245542]
IC50 0.2Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay [AID504184, Type: Literature]
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3
[SID24781888]
EC50_uM 0.474Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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4
[SID24781888]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID104245542]
EC50 1.1Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay [AID504181, Type: Literature]
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6
[SID104245542]
EC50 1.9Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay [AID504183, Type: Literature]
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7
[SID104245542]
IC50 1.94DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. [AID685528, Type: other]
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8
[SID24781888]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID104245542]
IC50 2.12Cytotoxicity against human PC3 cells after 72 hrs by MTT assay [AID664955, Type: Literature]
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10
[SID104245542]
IC50 2.18Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay [AID664956, Type: Literature]
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11
[SID104245542]
IC50 2.35Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay [AID664957, Type: Literature]
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12
[SID104245542]
IC50 2.5Inhibition of NF-kappaB activation in human K562 cells [AID504182, Type: Literature]
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13
[SID24781888]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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14
[SID24781888]
Potency 3.1623qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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15
[SID24781888]
Potency 3.2643qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay [AID602202, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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16
[SID24781888]
Potency 3.5481qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay [AID602200, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID24781888]
Potency 3.6626A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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18
[SID24781888]
Potency 4.1095qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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19
[SID24781888]
Potency 4.14qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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20
[SID24781888]
AC50_uM 4.246Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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21
[SID24781888]
Potency 4.6109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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22
[SID24781888]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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23
[SID24781888]
Potency 5.0119qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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24
[SID24781888]
Potency 5.0119qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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25
[SID24781888]
Potency 5.3233qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen [AID602199, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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26
[SID24781888]
Potency 6.3096qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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27
[SID24781888]
Potency 6.3096qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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28
[SID24781888]
Potency 7.0795Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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29
[SID24781888]
AC50_uM 8.702HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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30
[SID99494262]
IC50 9.9Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory] [geneid:29480]
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31
[SID99494262]
IC50 9.9Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory]regulator of G-protein signaling 4 [Rattus norvegicus] [gi:8394183]
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32
[SID24781888]
Potency 10qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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33
[SID24781888]
Potency 10qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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34
[SID24781888]
Absolute IC50 (CHOP) 10CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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35
[SID24781888]
Absolute IC50 (XBP1) 10XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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36
[SID24781888]
EC50_Mean 10.1Dose response confirmation of uHTS hits that enhance the survival of human induced pluripotent stem cells when cultured as single cells in a luminescent assay [AID623861, Type: confirmatory]
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37
[SID24781888]
Potency 11.2202qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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38
[SID24781888]
Potency 11.2202qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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39
[SID24781888]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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40
[SID99494262]
IC50 13.6Biochemical assay for compounds that inhibit AlF4- anion-dependent RGS4 binding to Galpha-o [AID588523, Type: confirmatory] [geneid:29480]
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41
[SID99494262]
IC50 13.6Biochemical assay for compounds that inhibit AlF4- anion-dependent RGS4 binding to Galpha-o [AID588523, Type: confirmatory]regulator of G-protein signaling 4 [Rattus norvegicus] [gi:8394183]
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42
[SID24781888]
Potency 18.3117qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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43
[SID24781888]
Potency 20.5962qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Cytotoxicity Assay [AID602204, Type: confirmatory]
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44
[SID24781888]
Potency 21.1923qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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45
[SID24781888]
Potency 22.3872qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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46
[SID24781888]
Potency 44.6684qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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47
[SID24781888]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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48
[SID24781888]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID652008, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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49
[SID24781888]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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50
[SID24781888]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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