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SMR000308205 (CID 6018993) - Compound BioActivity Data
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BioActivity Outcomes:
Active(99)
 
 
Inactive(525)
 
 
Inconclusive(32)
 
 
Unspecified(8)
 
 
Top Targets:
7tm 4(37)
 
 
 
RGS RGS4(9)
 
 
 
Pyr redox dim(8)
 
 
 
 
 
G-alpha(8)
 
 
 
Bcl-2 like(8)
 
 
BioAssay Types:
Screening(400)
 
 
 
 
Confirmatory(212)
 
 
 
 
 
Literature(31)
 
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(51)
 
 
 
 
 
EC50(15)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 598    Data Row: 664   Total Pages: 34   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104245542]
IC50 0.03DNDI: Inhibition of Human African Trypanosomiasis (HAT), STIB 795, in vitro [AID685529, Type: confirmatory]
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2
[SID104245542]
IC50 0.2Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay [AID504184, Type: Literature]
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3
[SID24781888]
EC50_uM 0.474Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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4
[SID24781888]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID104245542]
EC50 1.1Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay [AID504181, Type: Literature]
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6
[SID104245542]
IC50 1.2Antileishmanial activity against Leishmania amazonensis IFLA/BR/1967/PH-8 promastigotes infected in mouse peritoneal macrophages assessed as parasite growth inhibition after 48 hrs by MTT assay [AID1062980, Type: Literature]
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7
[SID104245542]
EC50 1.9Cytotoxicity against human MDA-MB-468 cells after 72 hrs by SRB assay [AID504183, Type: Literature]
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8
[SID104245542]
IC50 1.94DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. [AID685528, Type: confirmatory]
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9
[SID24781888]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID104245542]
IC50 2.12Cytotoxicity against human PC3 cells after 72 hrs by MTT assay [AID664955, Type: Literature]
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11
[SID104245542]
IC50 2.18Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay [AID664956, Type: Literature]
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12
[SID104245542]
IC50 2.35Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay [AID664957, Type: Literature]
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13
[SID104245542]
IC50 2.5Inhibition of NF-kappaB activation in human K562 cells [AID504182, Type: Literature]
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14
[SID24781888]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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15
[SID24781888]
Potency 3.1623qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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16
[SID24781888]
Potency 3.2643qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay [AID602202, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID24781888]
Potency 3.5481qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay [AID602200, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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18
[SID24781888]
Potency 3.6626A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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19
[SID24781888]
Potency 4.1095qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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20
[SID24781888]
Potency 4.14qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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