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Testosterone (CID 6013) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(942)
 
 
Inconclusive(56)
 
 
Unspecified(529)
 
 
Top Targets:
p450(44)
 
 
 
 
7TM GPCR Srx(43)
 
 
 
7TM GPCR Srsx(38)
 
 
 
NR LBD AR(36)
 
 
 
 
 
NR LBD ER(23)
 
 
 
 
 
BioAssay Types:
Confirmatory(527)
 
 
 
 
 
Screening(475)
 
 
 
Literature(389)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(376)
 
 
 
 
 
IC50(148)
 
 
 
 
Ki(10)
 
 
 
Kd(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1170    Data Row: 1596   Total Pages: 80   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234228]
Kd 0.000631Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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2
[SID104234228]
Ki 0.0014Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone [AID39296, Type: Literature]Androgen receptor [gi:113832]
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3
[SID144207887]
Ratio Potency (uM) 0.0014244qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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4
[SID17389513]
Potency 0.0016qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144207887]
Potency-Replicate_1 0.0017qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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6
[SID104234228]
EC50 0.002Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay [AID445833, Type: Literature]Androgen receptor [gi:113831]
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7
[SID104234228]
IC50 0.0027Binding affinity at AR [AID310114, Type: Literature]
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8
[SID104234228]
IC50 0.0027Binding affinity to androgen receptor [AID307522, Type: Literature]
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9
[SID104234228]
IC50 0.0027Inhibitory activity against AR [AID260157, Type: Literature]Androgen receptor [gi:113830]
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10
[SID104234228]
EC50 0.00316Agonist activity at androgen receptor in human MDA-KB2 cells transfected with MMTV linked luciferase assessed as transcriptional activation by luciferase reporter gene assay [AID445841, Type: Literature]Androgen receptor [gi:113830]
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11
[SID104234228]
IC50 0.0032In vitro antagonist activity against rat prostatic androgen receptor (AR) [AID39178, Type: Literature]
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12
[SID104234228]
IC50 0.0039Inhibition of human androgen receptor expressed in Escherichia coli [AID242138, Type: Literature]Androgen receptor [gi:113830]
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13
[SID104234228]
IC50 0.00457Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay [AID694143, Type: Literature]Androgen receptor [gi:113830]
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14
[SID104234228]
Ki 0.0049Inhibition of rat prostate cytosolic androgen receptor [AID238931, Type: Literature]
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15
[SID104234228]
Ki 0.0049Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand [AID39293, Type: Literature]
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16
[SID104234228]
IC50 0.00617DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: confirmatory]Androgen receptor [gi:113832]
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17
[SID104234228]
IC50 0.0065Displacement of [3H]Mibolerone from rat recombinant androgen receptor expressed in Escherichia coli after 4 hrs [AID751694, Type: Literature]Androgen receptor [gi:113832]
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18
[SID144207887]
Potency-Replicate_1 0.0069qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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19
[SID104234228]
IC50 0.014Displacement of [3H]DHT from human SHBG [AID274506, Type: Literature]Sex hormone-binding globulin [gi:134907]
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20
[SID144207887]
Potency-Replicate_1 0.0215qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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