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Cholesterol (CID 5997) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(234)
 
 
Inconclusive(13)
 
 
Unspecified(66)
 
 
Top Targets:
NR LBD ER(9)
 
 
 
NR LBD TR(9)
 
 
NR LBD AR(9)
 
 
 
NR LBD PPAR(7)
 
 
 
NR LBD GR(6)
 
 
 
BioAssay Types:
Literature(157)
 
 
 
 
 
Confirmatory(137)
 
 
 
 
Summary(15)
 
 
Screening(8)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
IC50(17)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 255    Data Row: 333   Total Pages: 17   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46393729]
Kd 0.3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structure Of Yeast Oxysterol Binding Protein Osh4 In Complex With Cholesterol [gi:75765756]
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2
[SID46393729]
Kd 0.3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structure Of Yeast Oxysterol Binding Protein Osh4 In Complex With Cholesterol [gi:75765756]
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3
[SID103333811]
Km 0.6Steady-state kinetic parameter on E361D mutant cholesterol oxidase [AID51774, Type: Literature]
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4
[SID103333811]
Km 3Steady-state kinetic parameter on wild-type cholesterol oxidase [AID51775, Type: Literature]
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5
[SID103333811]
Km 4.5Competitive inhibition constant (Km) for bovine cholesterol side-chain cleavage desmolase cytochrome P450 11A1 [AID56610, Type: Literature]Cholesterol side-chain cleavage enzyme, mitochondrial [gi:117259]
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6
[SID26754461]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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7
[SID103333811]
Antibacterial activity against Bacillus sp. by disc-diffusion assay [AID621755, Type: Literature]
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8
[SID103333811]
Antibacterial activity against Ochrobactrum pseudogrignonense 21-6 pin by disc-diffusion assay [AID621756, Type: Literature]
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9
[SID26754461]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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10
[SID26754461]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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11
[SID26754461]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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12
[SID26754461]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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13
[SID26754461]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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14
[SID103333811]
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control [AID1073278, Type: Literature]
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15
[SID103333811]
Binding affinity to Mycobacterium tuberculosis CYP124A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671391, Type: Literature]
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16
[SID103333811]
Binding affinity to Mycobacterium tuberculosis CYP142A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671393, Type: Literature]
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17
[SID103333811]
Growth promotion activity in Phytophthora cactorum at 10 mg/L in liquid culture medium [AID399109, Type: other]
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18
[SID103333811]
Inhibition of serum withdrawal-induced cell differentiation in mouse C2C12 cells assessed as myosin heavy chain expression [AID496785, Type: Literature]
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19
[SID46393729]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Yeast Oxysterol Binding Protein Osh4 In Complex With Cholesterol [gi:75765756]
View
20
[SID103333811]
Binding affinity to Mycobacterium tuberculosis CYP125A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671392, Type: Literature]Steroid C26-monooxygenase [gi:613781061]
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