Cholesterol (CID 5997) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(162)
 
 
Inconclusive(12)
 
 
Unspecified(63)
 
 
Top Targets:
NR LBD TR(6)
 
 
NR LBD PPAR(5)
 
 
 
p450(3)
 
 
 
NR LBD VDR(3)
 
 
 
NR LBD Fxr(2)
 
 
BioAssay Types:
Literature(146)
 
 
 
 
 
Confirmatory(82)
 
 
 
 
Screening(6)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
IC50(16)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 183    Data Row: 254   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103333811]
Km 0.6Steady-state kinetic parameter on E361D mutant cholesterol oxidase [AID51774, Type: Literature]
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2
[SID103333811]
Km 3Steady-state kinetic parameter on wild-type cholesterol oxidase [AID51775, Type: Literature]
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3
[SID103333811]
Km 4.5Competitive inhibition constant (Km) for bovine cholesterol side-chain cleavage desmolase cytochrome P450 11A1 [AID56610, Type: Literature]Cholesterol side-chain cleavage enzyme, mitochondrial [gi:117259]
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4
[SID26754461]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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5
[SID26754461]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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6
[SID26754461]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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7
[SID26754461]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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8
[SID26754461]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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9
[SID26754461]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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10
[SID103333811]
 Binding affinity to Mycobacterium tuberculosis CYP125A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671392, Type: Literature]Steroid C26-monooxygenase [gi:54040864]
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11
[SID103333811]
 Antibacterial activity against Bacillus sp. by disc-diffusion assay [AID621755, Type: Literature]
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12
[SID103333811]
 Antibacterial activity against Ochrobactrum pseudogrignonense 21-6 pin by disc-diffusion assay [AID621756, Type: Literature]
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13
[SID26754461]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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14
[SID26754461]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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15
[SID26754461]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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16
[SID103333811]
 Binding affinity to Mycobacterium tuberculosis CYP124A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671391, Type: Literature]
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17
[SID103333811]
 Binding affinity to Mycobacterium tuberculosis CYP142A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry [AID671393, Type: Literature]
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18
[SID46393729]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Yeast Oxysterol Binding Protein Osh4 In Complex With Cholesterol [gi:75765756]
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19
[SID103333811]
 Inhibition of serum withdrawal-induced cell differentiation in mouse C2C12 cells assessed as myosin heavy chain expression [AID496785, Type: Literature]
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20
[SID103333811]
 Growth promotion activity in Phytophthora cactorum at 10 mg/L in liquid culture medium [AID399109, Type: other]
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21
[SID103333811]
IC50 8.2TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cells [AID679734, Type: other]Multidrug resistance protein 1 [gi:238054374]
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22
[SID103333811]
IC50 8.2TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cells [AID679734, Type: other]Multidrug resistance protein 1 [gi:238054374]
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23
[SID103333811]
IC50 8.2TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cells [AID679734, Type: other]Multidrug resistance protein 1 [gi:238054374]
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24
[SID103333811]
IC50 42.6579Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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25
[SID103333811]
IC50 50Cytotoxicity against human HT-29 cells after 48 hrs by Alamar Blue assay [AID375536, Type: Literature]
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26
[SID103333811]
IC50 50Cytotoxicity against human CEM cells after 72 hrs by calcein AM assay [AID648615, Type: Literature]
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27
[SID103333811]
IC50 50Cytotoxicity against human MCF7 cells after 72 hrs by calcein AM assay [AID648616, Type: Literature]
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28
[SID103333811]
IC50 50Cytotoxicity against human HeLa cells after 72 hrs by calcein AM assay [AID648617, Type: Literature]
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29
[SID103333811]
IC50 50Cytotoxicity against human BJ cells after 72 hrs by calcein AM assay [AID648618, Type: Literature]
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30
[SID103333811]
IC50 200Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay [AID322753, Type: Literature]Lanosterol 14-alpha demethylase [gi:3915660]
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31
[SID103333811]
IC50 500Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units [AID242140, Type: Literature]DNA polymerase alpha catalytic subunit [gi:60392197]
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32
[SID103333811]
IC50 500Inhibitory concentration against human DNA topoisomerase II incubated with 0.05 units [AID242141, Type: Literature]DNA topoisomerase 2-alpha [gi:13959709]
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33
[SID103333811]
IC50 500Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 units [AID242084, Type: Literature]
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34
[SID103333811]
 Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay [AID492140, Type: Literature]
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35
[SID103333811]
 Antimicrobial activity Propionibacterium acnes ATCC 11827 after 2 days by broth dilution method [AID332912, Type: other]
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36
[SID103333811]
 Tested for its ability to activate Liver X receptor-alpha expressed as Relative efficacy determined by maximal increase in relative fluorescence in LiSA [AID101844, Type: Literature]
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37
[SID103333811]
 HDL (high density lipoproteins) cholesterol level in Wistar male rats [AID180064, Type: Literature]
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38
[SID103333811]
 LDL (low density lipoproteins) cholesterol level in Wistar male rats [AID184806, Type: Literature]
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39
[SID103333811]
 Cholesterol level in Wistar male rats [AID190828, Type: Literature]
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40
[SID103333811]
 Triglyceride level in Wistar male rats [AID196851, Type: Literature]
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41
[SID103333811]
 Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM [AID205268, Type: Literature]
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42
[SID103333811]
 Cytotoxicity against human SH-SY5Y cells overexpressing alpha-synuclein at 20 uM after 48 hrs by MTT assay [AID512701, Type: Literature]
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43
[SID103333811]
 Cytotoxicity against human SH-SY5Y cells overexpressing alpha-synuclein at 20 uM after 48 hrs by LDH assay [AID512702, Type: Literature]
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44
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as fluorescence after 48 hrs by Thioflavin T fluorescence assay [AID512703, Type: Literature]
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45
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as fluorescence after 72 hrs by Thioflavin T fluorescence assay [AID512704, Type: Literature]
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46
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as fluorescence after 96 hrs by Thioflavin T fluorescence assay [AID512705, Type: Literature]
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47
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as fluorescence after 330 hrs by Thioflavin T fluorescence assay [AID512706, Type: Literature]
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48
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as transition of alpha-synuclein from natively unfolded monomer to cross-beta-sheet conformation after 48 hrs by CD spectroscopy [AID512707, Type: Literature]
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49
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as transition of alpha-synuclein from natively unfolded monomer to cross-beta-sheet conformation after 72 hrs by CD spectroscopy [AID512708, Type: Literature]
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50
[SID103333811]
 Induction of alpha-synuclein aggregation in PBS buffer assessed as transition of alpha-synuclein from natively unfolded monomer to cross-beta-sheet conformation after 96 hrs by CD spectroscopy [AID512709, Type: Literature]
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