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Progesterone (CID 5994) - Compound BioActivity Data
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BioActivity Outcomes:
Active(272)
 
 
Inactive(2180)
 
 
Inconclusive(545)
 
 
Unspecified(388)
 
 
Top Targets:
7TM GPCR Srx(77)
 
 
 
 
7TM GPCR Srsx(61)
 
 
 
NR LBD ER(55)
 
 
 
 
 
NR LBD PPAR(48)
 
 
 
NR LBD AR(45)
 
 
 
 
 
BioAssay Types:
Confirmatory(1260)
 
 
 
 
 
Screening(1095)
 
 
 
 
Literature(375)
 
 
 
 
 
Summary(64)
 
 
 
 
BioActivity Types:
Potency(1040)
 
 
 
 
 
IC50(269)
 
 
 
 
EC50(45)
 
 
 
 
Ki(39)
 
 
 
 
Kd(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1742    Data Row: 3385   Total Pages: 68   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103175608]
EC50 0.0001Activation of progesterone receptor in human T47D cells after 20 hrs by PRE-tagged luciferase reporter gene assay [AID469431, Type: Literature]Progesterone receptor [gi:90110048]
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2
[SID103175608]
IC50 0.0002Binding affinity to progesterone receptor [AID569787, Type: other]
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3
[SID103175608]
Kd 0.00039Affinity for recombinant Mineralocorticoid receptor [AID126283, Type: Literature]Mineralocorticoid receptor [gi:126885]
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4
[SID103175608]
EC50 0.0005Agonist activity at human progesterone receptor [AID339656, Type: Literature]Progesterone receptor [gi:90110048]
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5
[SID103175608]
EC50 0.0009Activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cells [AID387085, Type: Literature]Progesterone receptor [gi:90110048]
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6
[SID103175608]
EC50 0.0009Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line. [AID208678, Type: Literature]Progesterone receptor [gi:90110048]
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7
[SID103175608]
EC50 0.00092Effective concentration against PR (progesterone receptor) [AID161810, Type: Literature]Progesterone receptor [gi:90110048]
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8
[SID103175608]
EC50 0.00092Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line [AID161815, Type: Literature]
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9
[SID103175608]
EC50 0.0015Effective concentration for half-maximal activation of human progesterone receptor expressed in CV-1 cells [AID162605, Type: Literature]Progesterone receptor [gi:90110048]
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10
[SID103175608]
EC50 0.0018Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell line [AID161816, Type: Literature]
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11
[SID103175608]
EC50 0.0018Agonistic activity against human progesterone receptor in T47D breast cancer cells [AID161789, Type: Literature]
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12
[SID103175608]
EC50 0.0018Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cells [AID161796, Type: Literature]
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13
[SID103175608]
EC50 0.0022Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activity [AID343211, Type: Literature]Progesterone receptor [gi:90110048]
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14
[SID103175608]
EC50 0.00289Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells. [AID161792, Type: Literature]Progesterone receptor [gi:90110048]
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15
[SID103175608]
EC50 0.0029Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cell [AID47046, Type: Literature]Progesterone receptor [gi:90110048]
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16
[SID103175608]
EC50 0.0029Human progesterone receptor (hPR) agonist activity expressed in CV-1 cells [AID161819, Type: Literature]Progesterone receptor [gi:90110048]
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17
[SID103175608]
EC50 0.0029Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells [AID161800, Type: Literature]
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18
[SID103175608]
EC50 0.0029Agonistic activity against human progesterone receptor in CV-1 cells [AID161788, Type: Literature]
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19
[SID103175608]
EC50 0.0029Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%) [AID161790, Type: Literature]
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20
[SID103175608]
EC50 0.0029Agonistic activity to the human progesterone receptor (hPR)assayed in CV-1 cells in cotransfection assay. [AID161791, Type: Literature]
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21
[SID103175608]
EC50 0.0029Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells [AID161794, Type: Literature]
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22
[SID103175608]
IC50 0.0034Displacement of [3H]progesterone at progesterone receptor of T47D cells [AID162464, Type: Literature]
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23
[SID103175608]
Ki 0.0034Binding affinity at human progesterone receptor [AID343234, Type: Literature]Progesterone receptor [gi:90110048]
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24
[SID103175608]
Ki 0.0035The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. [AID162298, Type: Literature]Progesterone receptor [gi:90110048]
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25
[SID103175608]
Ki 0.0035Binding affinity against baculovirus expressed human Progesterone receptor [AID162296, Type: Literature]Progesterone receptor [gi:90110048]
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26
[SID103175608]
IC50 0.0035Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cells [AID162132, Type: Literature]Progesterone receptor [gi:90110048]
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27
[SID103175608]
Ki 0.0035Binding affinity towards human progesterone receptor A isoform using progesterone as radioligand [AID162469, Type: Literature]
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28
[SID103175608]
Ki 0.0035Binding affinity determined for human Progesterone receptor A isoform [AID162470, Type: Literature]
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29
[SID103175608]
Ki 0.0035The binding affinity on Human progesterone receptor (hPR-A) using progesterone as radioligand. [AID162297, Type: Literature]
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30
[SID103175608]
Ki 0.0035Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay [AID162288, Type: Literature]
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31
[SID103175608]
Ki 0.0035Binding affinity against human progesterone receptor [AID162289, Type: Literature]
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32
[SID103175608]
Ki 0.0035Binding affinity to human progesterone receptor [AID162290, Type: Literature]
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33
[SID103175608]
Ki 0.0035Binding affinity against human progesterone receptor (hPR) in a competitive binding assay [AID162299, Type: Literature]
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34
[SID103175608]
Ki 0.0038Binding affinity for human progesterone receptor isoform A expressed in CV-1 cells [AID162603, Type: Literature]Progesterone receptor [gi:90110048]
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35
[SID103175608]
Kd 0.0039Equilibrium dissociation constant for rat uterine estrogen receptor binding [3H]estradiol [AID69387, Type: Literature]Estrogen receptor [gi:119600]
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36
[SID103175608]
Kd 0.0039Equilibrium dissociation constant for rat uterine estrogen receptor binding [3H]estradiol [AID69387, Type: Literature]Estrogen receptor beta [gi:6166156]
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37
[SID103175608]
IC50 0.005Binding affinity towards human progesterone receptor [AID162114, Type: Literature]Progesterone receptor [gi:90110048]
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38
[SID103175608]
Ki 0.0051Displacement of [3H]progesterone from human progesterone receptor B after 16 hrs by scintillation counting [AID487133, Type: Literature]Progesterone receptor [gi:90110048]
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39
[SID103175608]
IC50 0.006Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting [AID578353, Type: Literature]Progesterone receptor [gi:130896]
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40
[SID103175608]
IC50 0.006Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting [AID626474, Type: Literature]Progesterone receptor [gi:130896]
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41
[SID103175608]
Ki 0.0085Binding affinity against human androgen receptor [AID39145, Type: Literature]
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42
[SID103175608]
Ki 0.0085Binding affinity against baculovirus expressed human androgen receptor (hAR) [AID39146, Type: Literature]
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43
[SID103175608]
Ki 0.0085Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand. [AID39149, Type: Literature]
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44
[SID103175608]
Ki 0.0085Binding affinity for human Androgen receptor [AID39011, Type: Literature]Androgen receptor [gi:113830]
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45
[SID103175608]
Ki 0.0085Displacement of DHT from human androgen receptor [AID39142, Type: Literature]Androgen receptor [gi:113830]
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46
[SID103175608]
Ki 0.0085Displacement of DHT from human androgen receptor expressed in baculovirus SF-12 cells [AID39144, Type: Literature]Androgen receptor [gi:113830]
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47
[SID103175608]
Ki 0.0104Inhibition of [3H]R5020 binding to rabbit uterine progesterone receptor [AID162448, Type: Literature]Progesterone receptor [gi:130896]
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48
[SID103175608]
IC50 0.014Antagonist activity at mineralocorticoid receptor (hMR) [AID126264, Type: Literature]Mineralocorticoid receptor [gi:126885]
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49
[SID103175608]
IC50 0.014Inhibitory activity against human Mineralocorticoid receptor [AID126273, Type: Literature]Mineralocorticoid receptor [gi:126885]
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50
[SID103175608]
IC50 0.014Inhibitory activity (IC50) against human mineralocorticoid receptor expressed in CV-1 cells [AID47056, Type: Literature]Mineralocorticoid receptor [gi:126885]
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