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Chlordan (CID 5993) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(169)
 
 
Inconclusive(203)
 
 
Unspecified(3)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
 
Summary(24)
 
 
 
 
Literature(2)
 
 
 
BioActivity Types:
Potency(193)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 245    Data Row: 418   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207488]
Potency-Replicate_1 7.6724qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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2
[SID103469382]
IC50 10Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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3
[SID144207488]
Ratio Potency (uM) 13.13qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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4
[SID17389114]
Potency-Replicate_1 14.1254qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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5
[SID17389114]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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6
[SID144207488]
Potency-Replicate_1 21.6238qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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7
[SID144207488]
Potency-Replicate_1 21.8109qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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8
[SID144207488]
Potency-Replicate_1 21.8109qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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9
[SID144207488]
Potency-Replicate_1 24.2623qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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10
[SID144207488]
Potency-Replicate_1 24.4722qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
View
11
[SID17389114]
Potency 37.578qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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12
[SID17389114]
Potency 39.8107qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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13
[SID17389114]
Potency 42.1632qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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14
[SID144207488]
Potency-Replicate_1 48.8285qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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15
[SID17389114]
Potency 50.1187qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
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16
[SID17389114]
Potency 50.1187MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Dead Cells [AID961, Type: confirmatory]
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17
[SID144207488]
Potency-Replicate_1 54.3165qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
View
18
[SID144207488]
Ratio Potency (uM) 54.7528qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144207488]
Potency-Replicate_1 54.7864qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144207488]
Potency-Replicate_1 54.7864qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
View
21
[SID17389114]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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22
[SID17389114]
Potency-Replicate_1 66.8242qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID720652, Type: confirmatory]
View
23
[SID144207488]
Potency-Replicate_1 68.3804qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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24
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_70, Type: other]
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25
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_77, Type: other]
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26
[SID17389114]
Cell Viability - Jurkat [AID426, Type: confirmatory]
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27
[SID17389114]
Cell Viability - Hek293 [AID427, Type: confirmatory]
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28
[SID17389114]
Cell Viability - N2a [AID540, Type: confirmatory]
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29
[SID17389114]
Cell Viability - SH-SY5Y [AID544, Type: confirmatory]
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30
[SID17389114]
Cellular Toxicity (caspase-3) Jurkat [AID655, Type: confirmatory]
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31
[SID17389114]
Cellular Toxicity (caspase-3) Hek293 [AID664, Type: confirmatory]
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32
[SID17389114]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_36, Type: other]
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33
[SID17389114]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_62, Type: other]
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34
[SID17389114]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_77, Type: other]
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35
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_18, Type: other]
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36
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_36, Type: other]
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37
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_45, Type: other]
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38
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_49, Type: other]
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39
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_50, Type: other]
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40
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_58, Type: other]
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41
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_59, Type: other]
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42
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_61, Type: other]
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43
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_64, Type: other]
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44
[SID17389114]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813, Type: other]
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45
[SID17389114]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812, Type: other]
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46
[SID17389114]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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47
[SID144207488]
Potency-Replicate_1 10.8376qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
View
48
[SID17389114]
Potency 15.8489qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
49
[SID17389114]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
View
50
[SID17389114]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity [AID720636, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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