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Ethinyl Estradiol (CID 5991) - Compound BioActivity Data
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BioActivity Outcomes:
Active(133)
 
 
Inactive(1204)
 
 
Inconclusive(154)
 
 
Unspecified(1816)
 
 
Top Targets:
NR LBD ER(91)
 
 
 
 
 
NR LBD PPAR(40)
 
 
 
 
7TM GPCR Srx(39)
 
 
 
 
7TM GPCR Srsx(38)
 
 
 
 
p450(32)
 
 
 
 
 
BioAssay Types:
Confirmatory(805)
 
 
 
 
 
Screening(536)
 
 
 
 
Literature(324)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(594)
 
 
 
 
 
IC50(173)
 
 
 
 
 
EC50(10)
 
 
 
Ki(5)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2837    Data Row: 3307   Total Pages: 166   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192563]
IC50 0.000448DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: confirmatory]Estrogen receptor [gi:544257]
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2
[SID144208489]
Ratio Potency (uM) 0.000756751qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144210731]
Ratio Potency (uM) 0.001qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144208489]
Potency-Replicate_1 0.0012qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID144204698]
Ratio Potency (uM) 0.0015664qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID103192563]
IC50 0.002Binding affinity to ERalpha [AID264999, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID144204698]
Potency-Replicate_1 0.0021qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID103192563]
IC50 0.00804Binding affinity to ERalpha by fluorescence polarization-based competitive binding assay [AID478658, Type: Literature]
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9
[SID103192563]
IC50 0.0081Binding affinity to ERbeta [AID265000, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103192563]
IC50 0.01778Binding affinity to ERbeta by fluorescence polarization-based competitive binding assay [AID478659, Type: Literature]
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11
[SID103192563]
IC50 0.054DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103192563]
Kd 0.15488Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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13
[SID103192563]
IC50 0.559DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: confirmatory]Sodium-dependent dopamine transporter [gi:266667]
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14
[SID103192563]
IC50 0.57Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
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15
[SID144210731]
Ratio Potency (uM) 0.746844qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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16
[SID103192563]
IC50 0.959DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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17
[SID103192563]
IC50 1.067DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: confirmatory]Progesterone receptor [gi:75071465]
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18
[SID144208489]
Potency-Replicate_1 1.5377qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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19
[SID103192563]
IC50 1.634DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: confirmatory]Androgen receptor [gi:113832]
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20
[SID103192563]
IC50 1.71DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: confirmatory]Glucocorticoid receptor [gi:121069]
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