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Ethinyl Estradiol (CID 5991) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(132)
 
 
Inactive(1172)
 
 
Inconclusive(168)
 
 
Unspecified(1734)
 
 
Top Targets:
NR LBD ER(90)
 
 
 
 
 
7TM GPCR Srx(40)
 
 
 
 
NR LBD PPAR(40)
 
 
 
 
7TM GPCR Srsx(38)
 
 
 
 
p450(32)
 
 
 
 
 
BioAssay Types:
Confirmatory(688)
 
 
 
 
 
Screening(535)
 
 
 
 
Literature(298)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(592)
 
 
 
 
 
IC50(169)
 
 
 
 
EC50(10)
 
 
 
Ki(5)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2749    Data Row: 3206   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192563]
IC50 0.000448DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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2
[SID144208489]
Ratio Potency (uM) 0.000756751qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144210731]
Ratio Potency (uM) 0.001qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144208489]
Potency-Replicate_1 0.0012qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID144204698]
Ratio Potency (uM) 0.0015664qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID103192563]
IC50 0.002Binding affinity to ERalpha [AID264999, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID144204698]
Potency-Replicate_1 0.0021qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID103192563]
IC50 0.00804Binding affinity to ERalpha by fluorescence polarization-based competitive binding assay [AID478658, Type: Literature]
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9
[SID103192563]
IC50 0.0081Binding affinity to ERbeta [AID265000, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103192563]
IC50 0.01778Binding affinity to ERbeta by fluorescence polarization-based competitive binding assay [AID478659, Type: Literature]
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11
[SID103192563]
IC50 0.054DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103192563]
Kd 0.15488Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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13
[SID103192563]
IC50 0.559DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
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14
[SID103192563]
IC50 0.57Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
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15
[SID144208489]
Potency-Replicate_1 0.6868qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144210731]
Ratio Potency (uM) 0.746844qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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17
[SID103192563]
IC50 0.959DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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18
[SID103192563]
IC50 1.067DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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19
[SID103192563]
IC50 1.634DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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20
[SID103192563]
IC50 1.71DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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21
[SID103192563]
IC50 2.2Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay [AID721751, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
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22
[SID144204698]
Ratio Potency (uM) 2.39145qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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23
[SID144208489]
Ratio Potency (uM) 2.43702qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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24
[SID103192563]
EC50 3Cytotoxicity against HEK293 cells [AID345683, Type: Literature]
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25
[SID144210731]
Ratio Potency (uM) 4.53485qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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26
[SID103192563]
IC50 5.678DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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27
[SID144210731]
Potency-Replicate_1 6.1131qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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28
[SID144204698]
AR Potency (uM) 6.94386qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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29
[SID103192563]
IC50 6.987DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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30
[SID144208489]
Potency-Replicate_1 7.6411qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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31
[SID103192563]
IC50 7.953DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) [AID625220, Type: other]5-hydroxytryptamine receptor 4 [gi:6224984]
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32
[SID103192563]
IC50 8.12831Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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33
[SID144204698]
Potency-Replicate_1 8.4127qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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34
[SID144208489]
Ratio Potency (uM) 8.57349qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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35
[SID144210731]
Ratio Potency (uM) 8.63492qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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36
[SID103192563]
Km 9Drug glucuronidation reaction catalyzed by human recombinant UGT1A1 [AID624630, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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37
[SID8139942]
Potency 9.2qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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38
[SID144210731]
Potency-Replicate_1 9.6885qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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39
[SID17389896]
Potency 10qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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40
[SID144204698]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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41
[SID144204698]
Ratio Potency (uM) 12.5873qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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42
[SID26753042]
Potency 12.5893qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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43
[SID17389896]
Potency-Replicate_1 12.5893qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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44
[SID29215113]
Potency 12.8178S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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45
[SID144204698]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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46
[SID144204698]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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47
[SID144204698]
Potency-Replicate_1 13.3332qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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48
[SID144208489]
Potency-Replicate_1 13.5881qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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49
[SID144210731]
Potency-Replicate_1 13.6854qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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50
[SID144204698]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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