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Lysine (CID 5962) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(68)
 
 
Inconclusive(2)
 
 
Unspecified(18)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
 
NR LBD TR(3)
 
 
7TM GPCR Srsx(2)
 
 
BioAssay Types:
Confirmatory(48)
 
 
 
Literature(28)
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(61)
 
 
 
Kd(4)
 
 
Ki(3)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 97    Data Row: 97   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166507]
Kd 0.36Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc by in-line probing assay [AID513343, Type: Literature]
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2
[SID103166507]
Kd 1.7Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc [AID513352, Type: Literature]
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3
[SID103166507]
Kd 2.9Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif [AID513354, Type: Literature]
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4
[SID103166507]
Kd 3Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif [AID513353, Type: Literature]
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5
[SID103166507]
Inhibition of wild-type Bacillus subtilis lysine riboswitch 179 lysc assessed as decrease in transcription termination efficiency at 10 mM [AID513355, Type: Literature]
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6
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif assessed as decrease in transcription termination efficiency at 10 mM [AID513356, Type: Literature]
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7
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif assessed as decrease in transcription termination efficiency at 10 mM [AID513358, Type: Literature]
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8
[SID48416191]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID46393686]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of E. Coli Dihydrodipicolinate Synthase Bound With Allosteric Inhibitor (S)-Lysine To 2.0 A [gi:73535730]
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10
[SID103166507]
Ki 54.6Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysis [AID617312, Type: Literature]Glutathione reductase, mitochondrial [gi:14916998]
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11
[SID103166507]
IC50 61.2Inhibition of human erythrocyte Glutathione reductase [AID617311, Type: Literature]Glutathione reductase, mitochondrial [gi:14916998]
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12
[SID103166507]
Ki 2800Inhibition of recombinant N-glutathione transferase/human DDAH1 fusion protein [AID386454, Type: Literature]
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13
[SID103166507]
Inhibition of alpha-dicarbonyls-induced advanced glycation endproduct formation assessed as protection against 50 eq. MG-induced insulin degradation at 3.75 mM after 24 hrs by RP-HPLC [AID450158, Type: Literature]
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14
[SID103166507]
Inhibition of wild-type Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513346, Type: Literature]
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15
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513350, Type: Literature]
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16
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513351, Type: Literature]
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17
[SID103166507]
pKa was determined [AID26077, Type: Literature]
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18
[SID103166507]
Partition coefficient (logP) [AID26797, Type: Literature]
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19
[SID103166507]
Compound is evaluated for the growth of Escherichia coli W7 in the liquid medium at 100 ug/mL.; Absence of growth [AID64420, Type: Literature]
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20
[SID103166507]
Cleavage rate against hairpin ribozyme at 2 mM, in presence of 0.5 uM magnesium ions [AID198301, Type: Literature]
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21
[SID103166507]
Cleavage rate against hairpin ribozyme at 5 mM with 0.5 uM magnesium ions [AID198302, Type: Literature]
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22
[SID103166507]
Bitter threshold value [AID233318, Type: Literature]
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23
[SID103166507]
Permeability coefficient in human skin [AID311367, Type: Literature]
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24
[SID103166507]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: other]Monocarboxylate transporter 10 [gi:81871541]
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25
[SID103166507]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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26
[SID103166507]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681145, Type: other]SLC16A10 protein [gi:121945115]
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27
[SID103166507]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 60 uM, Lysine: 5000 uM) in Xenopus laevis oocytes [AID680402, Type: other]Solute carrier family 22 member 4 [gi:146345508]
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28
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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29
[SID144205711]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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30
[SID144205711]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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31
[SID144205711]
Ratio Potency (uM) qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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32
[SID144205711]
ATAD5 Potency (uM) qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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33
[SID144205711]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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34
[SID144205711]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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35
[SID144205711]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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36
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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37
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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38
[SID144205711]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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39
[SID144205711]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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40
[SID144205711]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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41
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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42
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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43
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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44
[SID144205711]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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45
[SID103166507]
MIC Antibacterial activity against Bacillus subtilis 168 1A1 after 24 hrs by CLSI method [AID513357, Type: Literature]
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46
[SID144205711]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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47
[SID144205711]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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48
[SID144205711]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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49
[SID144205711]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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50
[SID144205711]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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