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Lysine (CID 5962) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(70)
 
 
Inconclusive(1)
 
 
Unspecified(21)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
DHDPS(2)
 
 
BioAssay Types:
Confirmatory(49)
 
 
 
Literature(37)
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(62)
 
 
 
Ki(7)
 
 
 
Kd(4)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 102    Data Row: 105   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166507]
Kd 0.36Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc by in-line probing assay [AID513343, Type: Literature]
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2
[SID103166507]
Kd 1.7Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc [AID513352, Type: Literature]
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3
[SID103166507]
Kd 2.9Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif [AID513354, Type: Literature]
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4
[SID103166507]
Kd 3Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif [AID513353, Type: Literature]
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5
[SID46393686]
Ki 5Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Structure Of E. Coli Dihydrodipicolinate Synthase Bound With Allosteric Inhibitor (S)-Lysine To 2.0 A [gi:73535730]
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6
[SID46393686]
Ki 5Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain B, Structure Of E. Coli Dihydrodipicolinate Synthase Bound With Allosteric Inhibitor (S)-Lysine To 2.0 A [gi:73535731]
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7
[SID46392835]
Ki 36600Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Set Domain Of Lsmt Bound To Lysine And Adohcy [gi:33357815]
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8
[SID46392835]
Ki 36600Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Set Domain Of Lsmt Bound To Lysine And Adohcy [gi:33357815]
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9
[SID103166507]
Inhibition of wild-type Bacillus subtilis lysine riboswitch 179 lysc assessed as decrease in transcription termination efficiency at 10 mM [AID513355, Type: Literature]
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10
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif assessed as decrease in transcription termination efficiency at 10 mM [AID513356, Type: Literature]
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11
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif assessed as decrease in transcription termination efficiency at 10 mM [AID513358, Type: Literature]
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12
[SID48416191]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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13
[SID46393686]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: other]Chain A, Structure Of E. Coli Dihydrodipicolinate Synthase Bound With Allosteric Inhibitor (S)-Lysine To 2.0 A [gi:73535730]
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14
[SID103166507]
Ki 54.6Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysis [AID617312, Type: Literature]Glutathione reductase, mitochondrial [gi:14916998]
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15
[SID103166507]
IC50 61.2Inhibition of human erythrocyte Glutathione reductase [AID617311, Type: Literature]Glutathione reductase, mitochondrial [gi:14916998]
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16
[SID103166507]
Ki 2800Inhibition of recombinant N-glutathione transferase/human DDAH1 fusion protein [AID386454, Type: Literature]
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17
[SID103166507]
Inhibition of alpha-dicarbonyls-induced advanced glycation end product formation assessed as protection against 50 eq. MG-induced insulin degradation at 3.75 mM after 24 hrs by RP-HPLC [AID450158, Type: Literature]
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18
[SID103166507]
Inhibition of wild-type Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513346, Type: Literature]
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19
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513350, Type: Literature]
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20
[SID103166507]
Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay [AID513351, Type: Literature]
View