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Aspartic Acid (CID 5960) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(279)
 
 
Inconclusive(26)
 
 
Unspecified(27)
 
 
Top Targets:
p450(9)
 
 
 
PLN02808(8)
 
 
PLDc mTdp1 2(7)
 
 
HELICc(7)
 
 
 
7TM GPCR Srx(7)
 
 
BioAssay Types:
Confirmatory(277)
 
 
 
 
Literature(40)
 
 
 
 
 
Screening(12)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(253)
 
 
 
 
Kd(3)
 
 
EC50(3)
 
 
IC50(2)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 246    Data Row: 340   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103172284]
Kd 0.001Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter L130W mutant fluorescence-based assay in presence of NaCl [AID328865, Type: Literature]
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2
[SID103172284]
Kd 0.002Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter [AID328866, Type: Literature]
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3
[SID103172284]
Kd 0.094Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter by isothermal titration calorimetry in presence of NaCl [AID328869, Type: Literature]
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4
[SID103172284]
IC50 1.638Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor [AID144612, Type: Literature]
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5
[SID103172284]
IC50 10Displacement of [3H]CPP from N-methyl-D-aspartate glutamate receptor in rat brain membrane [AID144456, Type: Literature]
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6
[SID103172284]
Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) [AID50347, Type: Literature]
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7
[SID103172284]
Induction of nitrogen-starved wild type sigma1278b yeast Gap1-mediated trehalose activation at 10 mM [AID500825, Type: Literature]
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8
[SID48415581]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID103172284]
EC50 1000Agonistic activity at mGlu6 receptor expressed in CHO cells [AID107251, Type: Literature]
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10
[SID103172284]
EC50 1000Agonistic activity at mGlu1-alpha receptor expressed in CHO cells [AID108645, Type: Literature]
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11
[SID103172284]
EC50 1000Agonistic activity at mGlu2 receptor expressed in CHO cells [AID109003, Type: Literature]
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12
[SID103172284]
Compound was tested for its uptake by the 7800C1 cells [AID166060, Type: Literature]
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13
[SID103172284]
Compound was tested for its uptake by the R5 cells [AID166061, Type: Literature]
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14
[SID11113409]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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15
[SID103172284]
Ischemic myocardial residue fraction of [13N]-labeled amino acid was observed with a single pass uptake technique in open-chest instrumented dogs (control - 14+/-4.2) [AID58928, Type: Literature]
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16
[SID103172284]
Compound was tested for its uptake by the GH4C1 cells [AID73049, Type: Literature]
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17
[SID103172284]
Compound was tested for its uptake by the H4 cells [AID80822, Type: Literature]
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18
[SID103172284]
Tested for its reversal effect on growth of H4 cells at 133 ug/mL concentrations of L-aspargine and DL-threo-beta-fluoroaspartate [AID80832, Type: Literature]
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19
[SID103172284]
Tested for its reversal effect on growth of H4 cells at 330 ug/mL concentrations of L-aspargine and DL-threo-beta-fluoroaspartate [AID80836, Type: Literature]
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20
[SID103172284]
Compound was tested for its uptake by the Jensen sarcoma cells [AID94789, Type: Literature]
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21
[SID103172284]
Compound was tested for its uptake by the MH1C1 cells [AID106504, Type: Literature]
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22
[SID103172284]
Distribution of radioactivity derived form [C14]-labeled compound taken up by 7800C1 cells [AID15291, Type: Literature]
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23
[SID103172284]
Distribution of radioactivity derived form [C14]-labeled compound taken up by 7800C1 cells; acid insoluble (nucleic acids) [AID15416, Type: Literature]
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24
[SID103172284]
Distribution of radioactivity derived form [C14]-labeled compound taken up by 7800C1 cells; acid insoluble (protein) [AID15417, Type: Literature]
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25
[SID103172284]
Distribution of radioactivity derived form [C14]-labeled compound taken up by 7800C1 cells; acid soluble [AID15418, Type: Literature]
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26
[SID103172284]
Distribution of radioactivity derived form [C14]-labeled compound taken up by 7800C1 cells; total uptake [AID15419, Type: Literature]
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27
[SID103172284]
Percent recovery form [C14]-labeled compound taken up by 7800C1 cells [AID20334, Type: Literature]
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28
[SID103172284]
Ischemic myocardial half-life measured after intracoronary injection of [13N]-labeled amino acid in dogs (control - 147+/-12) [AID22734, Type: Literature]
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29
[SID103172284]
Partition coefficient (logP) [AID26797, Type: Literature]
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30
[SID103172284]
Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) [AID47753, Type: Literature]
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31
[SID103172284]
Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes [AID48116, Type: Literature]
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32
[SID103172284]
Bitter threshold value; NB denotes 'Not bitter' [AID233320, Type: Literature]
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33
[SID103172284]
Permeability coefficient in human skin [AID311367, Type: Literature]
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34
[SID50104339]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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35
[SID103172284]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: other]Monocarboxylate transporter 10 [gi:81871541]
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36
[SID90340967]
Potency 9.5283qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay [AID720538, Type: confirmatory]arylsulfatase A [Homo sapiens] [gi:220983390]
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37
[SID50104339]
Potency 14.1254qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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38
[SID50104339]
Potency 14.1254qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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39
[SID11113409]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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40
[SID50104339]
Potency 44.6684qHTS Validation Assay for Identification of Novel General Anesthetics [AID2323, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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41
[SID11113409]
Potency 63.0957qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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42
[SID26751648]
Potency 89.1251qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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43
[SID50104339]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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44
[SID50104339]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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45
[SID17404696]
HTS for 14-3-3 protein interaction modulators [AID422, Type: screening]14-3-3 protein gamma [Homo sapiens] [gi:21464101]
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46
[SID11113409]
Potency qHTS for inhibitors of Vif-A3G interactions: Validation [AID588379, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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47
[SID11113409]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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48
[SID11113409]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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49
[SID11113409]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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50
[SID11113409]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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