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Alanine (CID 5950) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(93)
 
 
Inconclusive(3)
 
 
Unspecified(11)
 
 
Top Targets:
p450(9)
 
 
HSD10-like SD..(4)
 
 
PLDc mTdp1 2(3)
 
 
 
Tubulin-bindi..(3)
 
 
IMPase(2)
 
 
BioAssay Types:
Confirmatory(89)
 
 
 
Literature(12)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(69)
 
 
 
Ki(2)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 98    Data Row: 108   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103182286]
Drug uptake in Escherichia coli ATCC 10536 assessed as membrane localization at 3 uM after 30 mins by confocal microscopic analysis [AID722314, Type: Literature]
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2
[SID103182286]
IC50 78Inhibition of binding of [3H]strychnine to N-methyl-D-aspartate glutamate receptor 1 in rat [AID143466, Type: Literature]
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3
[SID103182286]
IC50 198Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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4
[SID103182286]
Km 14200Km value for Alanine racemase from Pseudomonas aeruginosa [AID33397, Type: Literature]
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5
[SID103182286]
Tested in vitro for activation of Human cloned isozyme carbonic anhydrase II (hCA II) [AID47753, Type: Literature]
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6
[SID103182286]
Tested in vitro for activation of carbonic anhydrase IV (bCA IV), purified from bovine lung microsomes [AID48116, Type: Literature]
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7
[SID103182286]
Tested in vitro for activation of Human cloned isozyme carbonic anhydrase I (hCA I) [AID50347, Type: Literature]
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8
[SID103182286]
Ischemic myocardial residue fraction of [13N]-labeled amino acid was observed with a single pass uptake technique in open-chest instrumented dogs (control - 18.5+/-2.1) [AID58930, Type: Literature]
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9
[SID11113404]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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10
[SID103182286]
Ischemic myocardial half-life measured after intracoronary injection of [13N]-labeled amino acid in dogs (control - 88+/-2) [AID22736, Type: Literature]
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11
[SID103182286]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: Literature]Monocarboxylate transporter 10 [gi:81871541]
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12
[SID103182286]
Ki Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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13
[SID11113404]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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14
[SID11113404]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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15
[SID11113404]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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16
[SID11113404]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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17
[SID11113404]
GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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18
[SID11113404]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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19
[SID11113404]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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20
[SID11113404]
Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450 2D6 isoform 2 [Homo sapiens] [gi:68509921]
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