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BioActivity Data for Compound AC1NZNJC (CID 5937406)

BioActivity Outcomes:
Active(49)
 
 
Inactive(697)
 
 
Inconclusive(36)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(43)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(9)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(530)
 
 
 
 
 
Confirmatory(228)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(120)
 
 
 
Toxicity(9)
 
 
 
Cell-based(135)
 
 
 
 
Organism-base..(14)
 
 
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(50)
 
 
 
 
EC50(17)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 717    Data Row: 784   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14741094]
IC50 1.554High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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2
[SID14741094]
EC50 1.969Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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3
[SID14741094]
Potency 3.5481qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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4
[SID14741094]
AC50_uM 3.645Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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5
[SID14741094]
AC50_uM 4.086HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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6
[SID14741094]
EC50_MICROM 6.134Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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7
[SID14741094]
IC50_Artemis_Mean 11Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay [AID720701, Type: confirmatory]protein artemis isoform a [Homo sapiens] [gi:76496497]
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8
[SID14741094]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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9
[SID14741094]
Potency 14.581A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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10
[SID14741094]
Potency 16.9441qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID14741094]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID14741094]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID14741094]
Fluorescence-based biochemical high throughput confirmation assay to identify inhibitors of Protein Phosphatase 1 (PP1) [AID2358, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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14
[SID14741094]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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15
[SID14741094]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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16
[SID14741094]
Second counter screen for compounds that modulate the two-pore domain potassium channel (KCNK9) [AID492997, Type: screening]potassium channel subfamily K member 9 [Homo sapiens] [gi:7706135]
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17
[SID14741094]
Confirmatory screen for identification of compounds that inhibit the two-pore domain potassium channel (KCNK9) [AID492992, Type: screening]potassium channel subfamily K member 9 [Homo sapiens] [gi:7706135]
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18
[SID14741094]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]potassium channel subfamily K member 9 [Homo sapiens] [gi:7706135]
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19
[SID14741094]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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20
[SID14741094]
Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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