Isoflurophate (CID 5936) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(89)
 
 
Inconclusive(3)
 
 
Unspecified(5)
 
 
Top Targets:
Esterase lipa..(6)
 
 
 
DUF3652(2)
 
 
Geminin(2)
 
 
Menin(2)
 
 
NR LBD ROR li..(2)
 
 
BioAssay Types:
Literature(75)
 
 
 
 
 
Confirmatory(29)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(28)
 
 
 
IC50(8)
 
 
 
Ki(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 106   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103274564]
IC50 0.05Inhibition of porcine liver carboxylesterase using [14C]GS-7340 substrate [AID279735, Type: Literature]Liver carboxylesterase [gi:2494384]
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2
[SID103274564]
IC50 0.12Inhibition of human AChE by modified Ellman's spectrophotometric method [AID462368, Type: Literature]Acetylcholinesterase [gi:113037]
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3
[SID103274564]
IC50 0.48In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30849, Type: Literature]
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4
[SID103274564]
IC50 5Inhibition of purified prodrug hydrolase using [14C]GS-7340 substrate [AID279731, Type: Literature]
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5
[SID103274564]
Ki 6Inhibition of human AChE assessed as equilibrium binding by modified Ellman's spectrophotometric method [AID462369, Type: Literature]Acetylcholinesterase [gi:113037]
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6
[SID103274564]
IC50 10Inhibition of recombinant CatA using [14C]GS-7340 substrate [AID279732, Type: Literature]Lysosomal protective protein [gi:20178316]
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7
[SID103274564]
IC50 20Inhibition of crude human PBMC extract prodrug hydrolase using [14C]GS-7340 substrate [AID279733, Type: Literature]
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8
[SID103274564]
Ki Binding affinity to human AChE [AID404441, Type: Literature]Acetylcholinesterase [gi:113037]
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9
[SID103274564]
 Inhibition of esterase mediated-hydrolysis of tenofovir disoproxil fumarate in human intestinal sub cellular fraction S9 assessed as rate of tenofovir disoproxil fumarate degradation at 2 uM after 30 mins [AID417046, Type: Literature]
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10
[SID103274564]
Ki 33000In vitro inhibition of N8-Acetylspermidine deacetylase from rat liver cytosol(apparent Ki) [AID144355, Type: Literature]
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11
[SID103274564]
 In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30864, Type: Literature]
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12
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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13
[SID103274564]
IC50 Inhibition of Torpedo californica AChE [AID404434, Type: Literature]Acetylcholinesterase [gi:543754]
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14
[SID103274564]
IC50 Inhibition of human AChE [AID407780, Type: Literature]Acetylcholinesterase [gi:113037]
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15
[SID50113285]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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16
[SID144206196]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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17
[SID144206196]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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18
[SID144206196]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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19
[SID144206196]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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20
[SID144206196]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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21
[SID144206196]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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22
[SID144206196]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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23
[SID144206196]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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24
[SID50113285]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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25
[SID50113285]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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26
[SID50113285]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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27
[SID50113285]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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28
[SID50113285]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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29
[SID50113285]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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30
[SID50113285]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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31
[SID50113285]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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32
[SID50113285]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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33
[SID50113285]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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34
[SID50113285]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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35
[SID50113285]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
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36
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
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37
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_5, Type: Literature]
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38
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_6, Type: Literature]
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39
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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40
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_8, Type: Literature]
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41
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_9, Type: Literature]
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42
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_10, Type: Literature]
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43
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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44
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_12, Type: Literature]
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45
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_13, Type: Literature]
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46
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_14, Type: Literature]
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47
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_15, Type: Literature]
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48
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_16, Type: Literature]
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49
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_17, Type: Literature]
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50
[SID50113285]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_18, Type: Literature]
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