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BioActivity Data for Compound Isoflurophate (CID 5936)

BioActivity Outcomes:
Active(11)
 
 
Inactive(149)
 
 
Inconclusive(7)
 
 
Unspecified(140)
 
 
Top Targets:
Esterase lipa..(10)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
 
Bromo ALL-1(3)
 
 
BioAssay Types:
Confirmatory(78)
 
 
 
Literature(77)
 
 
 
 
 
Summary(15)
 
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(3)
 
 
 
In vivo(135)
 
 
Biochemical(14)
 
 
 
 
Toxicity(141)
 
 
 
BioActivity Types:
Potency(90)
 
 
 
IC50(8)
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 243    Data Row: 307   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103274564]
IC50 0.05Inhibition of porcine liver carboxylesterase using [14C]GS-7340 substrate [AID279735, Type: Literature]Liver carboxylesterase [gi:2494384]
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2
[SID103274564]
IC50 0.12Inhibition of human AChE by modified Ellman's spectrophotometric method [AID462368, Type: Literature]Acetylcholinesterase [gi:113037]
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3
[SID103274564]
IC50 0.48In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30849, Type: Literature]Acetylcholinesterase [gi:14916521]
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4
[SID103274564]
IC50 5Inhibition of purified prodrug hydrolase using [14C]GS-7340 substrate [AID279731, Type: Literature]
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5
[SID103274564]
Ki 6Inhibition of human AChE assessed as equilibrium binding by modified Ellman's spectrophotometric method [AID462369, Type: Literature]Acetylcholinesterase [gi:113037]
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6
[SID103274564]
IC50 10Inhibition of recombinant CatA using [14C]GS-7340 substrate [AID279732, Type: Literature]Lysosomal protective protein [gi:20178316]
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7
[SID103274564]
IC50 20Inhibition of crude human PBMC extract prodrug hydrolase using [14C]GS-7340 substrate [AID279733, Type: Literature]
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8
[SID103274564]
Acetylcholinesterase inhibitor [AID742924, Type: Literature]Acetylcholinesterase [gi:113037]
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9
[SID103274564]
Acetylcholinesterase inhibitor [AID742924, Type: Literature]Acetylcholinesterase [gi:113037]
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10
[SID103274564]
Ki Binding affinity to human AChE [AID404441, Type: Literature]Acetylcholinesterase [gi:113037]
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11
[SID103274564]
Inhibition of esterase mediated-hydrolysis of tenofovir disoproxil fumarate in human intestinal sub cellular fraction S9 assessed as rate of tenofovir disoproxil fumarate degradation at 2 uM after 30 mins [AID417046, Type: Literature]
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12
[SID103274564]
Ki 33000In vitro inhibition of N8-Acetylspermidine deacetylase from rat liver cytosol(apparent Ki) [AID144355, Type: Literature]
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13
[SID103274564]
IC50 Inhibition of human AChE [AID407780, Type: Literature]Acetylcholinesterase [gi:113037]
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14
[SID103274564]
In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30864, Type: Literature]Acetylcholinesterase [gi:14916521]
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15
[SID103274564]
IC50 Inhibition of Torpedo californica AChE [AID404434, Type: Literature]Acetylcholinesterase [gi:543754]
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16
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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17
[SID103274564]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: RBCNUC (Nucleated Erythrocytes); Study_ID: S020729 [AID928260, Type: other]
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18
[SID103274564]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: NEUTSG (Neutrophils, Segmented); Study_ID: S020729 [AID928261, Type: other]
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19
[SID103274564]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: MCHC (Ery. Mean Corpuscular HGB Concentration); Study_ID: S020729 [AID928262, Type: other]
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20
[SID103274564]
DrugMatrix: Regimen: Daily Repeat; Time: 3 day; Dose: High; Vehicle: 100 % water; Route: oral gavage | Dataset: Hematology; Assay: EOSLE (Eosinophils/Leukocytes); Study_ID: S020729 [AID928263, Type: other]
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