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Isoflurophate (CID 5936) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(146)
 
 
Inconclusive(9)
 
 
Unspecified(5)
 
 
Top Targets:
Esterase lipa..(9)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
 
Bromo ALL-1(3)
 
 
BioAssay Types:
Confirmatory(77)
 
 
 
Literature(75)
 
 
 
 
 
Summary(15)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(89)
 
 
 
IC50(8)
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 107    Data Row: 170   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103274564]
IC50 0.05Inhibition of porcine liver carboxylesterase using [14C]GS-7340 substrate [AID279735, Type: Literature]Liver carboxylesterase [gi:2494384]
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2
[SID103274564]
IC50 0.12Inhibition of human AChE by modified Ellman's spectrophotometric method [AID462368, Type: Literature]Acetylcholinesterase [gi:113037]
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3
[SID103274564]
IC50 0.48In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30849, Type: Literature]Acetylcholinesterase [gi:14916521]
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4
[SID103274564]
IC50 5Inhibition of purified prodrug hydrolase using [14C]GS-7340 substrate [AID279731, Type: Literature]
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5
[SID103274564]
Ki 6Inhibition of human AChE assessed as equilibrium binding by modified Ellman's spectrophotometric method [AID462369, Type: Literature]Acetylcholinesterase [gi:113037]
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6
[SID103274564]
IC50 10Inhibition of recombinant CatA using [14C]GS-7340 substrate [AID279732, Type: Literature]Lysosomal protective protein [gi:20178316]
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7
[SID103274564]
IC50 20Inhibition of crude human PBMC extract prodrug hydrolase using [14C]GS-7340 substrate [AID279733, Type: Literature]
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8
[SID103274564]
Inhibition of esterase mediated-hydrolysis of tenofovir disoproxil fumarate in human intestinal sub cellular fraction S9 assessed as rate of tenofovir disoproxil fumarate degradation at 2 uM after 30 mins [AID417046, Type: Literature]
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9
[SID103274564]
Acetylcholinesterase inhibitor [AID742924, Type: other]Acetylcholinesterase [gi:113037]
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10
[SID103274564]
Ki Binding affinity to human AChE [AID404441, Type: Literature]Acetylcholinesterase [gi:113037]
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11
[SID103274564]
Ki 33000In vitro inhibition of N8-Acetylspermidine deacetylase from rat liver cytosol(apparent Ki) [AID144355, Type: Literature]
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12
[SID103274564]
In vitro inhibitory activity against acetylcholinesterase from electric eel [AID30864, Type: Literature]Acetylcholinesterase [gi:14916521]
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13
[SID103274564]
IC50 Inhibition of human AChE [AID407780, Type: Literature]Acetylcholinesterase [gi:113037]
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14
[SID103274564]
IC50 Inhibition of Torpedo californica AChE [AID404434, Type: Literature]Acetylcholinesterase [gi:543754]
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15
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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16
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_1, Type: Literature]
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17
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
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18
[SID144206196]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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19
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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20
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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21
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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22
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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23
[SID144206196]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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24
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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25
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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26
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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27
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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28
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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29
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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30
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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31
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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32
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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33
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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34
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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35
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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36
[SID144206196]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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37
[SID144206196]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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38
[SID144206196]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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39
[SID144206196]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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40
[SID144206196]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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41
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
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42
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_5, Type: Literature]
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43
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_6, Type: Literature]
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44
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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45
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_8, Type: Literature]
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46
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_9, Type: Literature]
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47
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_10, Type: Literature]
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48
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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49
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_12, Type: Literature]
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50
[SID50113285]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_13, Type: Literature]
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