Bookmark and Share
Triiodothyronine (CID 5920) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(97)
 
 
Inactive(956)
 
 
Inconclusive(92)
 
 
Unspecified(288)
 
 
Top Targets:
NR LBD TR(51)
 
 
 
 
 
7TM GPCR Srx(41)
 
 
 
 
7TM GPCR Srsx(38)
 
 
 
 
NR LBD PPAR(24)
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
BioAssay Types:
Screening(569)
 
 
 
 
Confirmatory(380)
 
 
 
 
 
Literature(250)
 
 
 
 
 
Summary(39)
 
 
 
 
BioActivity Types:
Potency(356)
 
 
 
 
 
IC50(168)
 
 
 
 
EC50(16)
 
 
 
Ki(12)
 
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1142    Data Row: 1433   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103570000]
Kd 5.8e-05Displacement of [125I]T3 from human TRalpha receptor [AID323174, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
2
[SID103570000]
Kd 6e-05Binding affinity of compound was determined against Thyroid hormone receptor alpha1 [AID213173, Type: Literature]
View
3
[SID103570000]
Ki 8e-05Inhibitory activity against [125I]T3 binding to human TRbeta1 receptor [AID213186, Type: Literature]
View
4
[SID103570000]
Kd 8.1e-05Displacement of [125I]T3 from human TRbeta receptor [AID323175, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
5
[SID103570000]
Kd 8.7e-05Binding affinity of compound was determined against thyroid hormone receptor beta 1 [AID213185, Type: Literature]
View
6
[SID103570000]
Kd 0.0001Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 [AID213183, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
7
[SID103570000]
Kd 0.0001Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 [AID213172, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
8
[SID103570000]
Kd 0.00014Binding affinity towards thyroid hormone receptor (hTR beta 1) [AID213176, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
9
[SID103570000]
Kd 0.00017Binding affinity towards thyroid hormone receptor (hTR alpha 1) [AID213166, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
10
[SID103570000]
Ki 0.00022Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha expressed in sf9 cells by scintillation proximity assay [AID385607, Type: Literature]
View
11
[SID103570000]
IC50 0.00024Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 [AID254851, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
12
[SID103570000]
IC50 0.00024Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells [AID299560, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
13
[SID103570000]
IC50 0.000257Inhibition of human thyroid hormone receptor beta 1 [AID299948, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
14
[SID103570000]
IC50 0.00026Inhibitory concentration against cloned human thyroid hormone receptor beta 1 [AID254845, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
15
[SID103570000]
IC50 0.00026Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells [AID299561, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
16
[SID103570000]
Ki 0.00033Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay [AID345695, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
17
[SID103570000]
IC50 0.00038Inhibition of rat thyroid hormone receptor [AID566277, Type: Literature]
View
18
[SID103570000]
Ki 0.00055Displacement of [125I]T3 from recombinant thyroid hormone receptor beta expressed in sf9 cells by scintillation proximity assay [AID385608, Type: Literature]
View
19
[SID103570000]
Ki 0.00068Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay [AID345696, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
20
[SID103570000]
IC50 0.0011Inhibition of [125I]L-T3 binding to rat hepatic 3,5,3''-triiodo-L-thyronine receptor [AID3248, Type: Literature]
View
21
[SID103570000]
Ki 0.00156In vitro concentration required todisplace [125I]L-T3 from rat hepatic nuclei. [AID213188, Type: Literature]
View
22
[SID103570000]
EC50 0.002Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity) [AID213168, Type: Literature]
View
23
[SID103570000]
EC50 0.002Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) [AID213169, Type: Literature]
View
24
[SID103570000]
EC50 0.002Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity) [AID213179, Type: Literature]
View
25
[SID103570000]
EC50 0.002Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1) [AID213180, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
26
[SID144203580]
Potency-Replicate_1 0.0021qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
27
[SID103570000]
Ki 0.00229Displacement of [125I]T3 from human recombinant thyroid harmone receptor beta after 16 to 48 hrs by gamma-ray detection [AID664440, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
28
[SID103570000]
Ki 0.00229Displacement of [125I]-T3 from human TRbeta expressed in insect cells after 16 to 48 hrs by gamma-counting [AID722580, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
29
[SID144212260]
Potency-Replicate_1 0.0023qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
30
[SID103570000]
Ki 0.00233Displacement of [125I]T3 from human recombinant thyroid harmone receptor alpha after 16 to 48 hrs by gamma-ray detection [AID664441, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
31
[SID103570000]
Ki 0.00233Displacement of [125I]-T3 from human TRalpha expressed in insect cells after 16 to 48 hrs by gamma-counting [AID722581, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
32
[SID103570000]
EC50 0.0024Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay [AID323178, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
33
[SID103570000]
EC50 0.0024Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay [AID323176, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
View
34
[SID103570000]
EC50 0.0024Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay [AID323179, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
35
[SID103570000]
IC50 0.0044In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor [AID146670, Type: Literature]
View
36
[SID103570000]
EC50 0.011Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay [AID323177, Type: Literature]Thyroid hormone receptor beta [gi:586092]
View
37
[SID103570000]
IC50 0.4109DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A1 [gi:231473]
View
38
[SID103570000]
IC50 0.5In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor [AID160006, Type: Literature]
View
39
[SID144203580]
AhR Potency (uM) 3.34915qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
40
[SID103570000]
IC50 3.6Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay [AID739861, Type: Literature]Proliferating cell nuclear antigen [gi:129694]
View
41
[SID144203580]
Potency-Replicate_1 5.308qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
42
[SID103570000]
EC50 7Non-competitive inhibitory activity against recombinant Gamma-aminobutyric acid A (GABA-A) receptor [AID71696, Type: Literature]
View
43
[SID144203580]
Potency-Replicate_1 9.5112qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
44
[SID144203580]
Ratio Potency (uM) 9.5112qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
45
[SID144212260]
AhR Potency (uM) 10.4678qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
46
[SID144203580]
ER Potency (uM) 22.3838qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
47
[SID103570000]
IC50 23Direct channel-gating action blocked by picrotoxin [AID226684, Type: Literature]
View
48
[SID144203580]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
49
[SID144203580]
Potency-Replicate_1 23.7101qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
50
[SID144203580]
Ratio Potency (uM) 23.9145qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View