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Triiodothyronine (CID 5920) - Compound BioActivity Data
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BioActivity Outcomes:
Active(99)
 
 
Inactive(967)
 
 
Inconclusive(89)
 
 
Unspecified(528)
 
 
Top Targets:
NR LBD TR(53)
 
 
 
 
 
7TM GPCR Srx(41)
 
 
 
 
7TM GPCR Srsx(38)
 
 
 
 
NR LBD PPAR(24)
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
BioAssay Types:
Screening(569)
 
 
 
 
Confirmatory(497)
 
 
 
 
 
Literature(287)
 
 
 
 
 
Summary(39)
 
 
 
 
BioActivity Types:
Potency(357)
 
 
 
 
 
IC50(169)
 
 
 
 
EC50(16)
 
 
 
Ki(12)
 
 
 
Kd(10)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1385    Data Row: 1683   Total Pages: 85   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103570000]
IC50 3.4e-05Displacement of [125I]Triiodothyronine from thyroid hormone receptor in Wistar rat liver after 18 hrs [AID751642, Type: Literature]
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2
[SID103570000]
Kd 5.8e-05Displacement of [125I]T3 from human TRalpha receptor [AID323174, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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3
[SID103570000]
Kd 6e-05Binding affinity of compound was determined against Thyroid hormone receptor alpha1 [AID213173, Type: Literature]
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4
[SID46393605]
Kd 6e-05Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain X, Thyroxine-Thyroid Hormone Receptor Interactions [gi:61679703]
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5
[SID46393605]
Kd 6e-05Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain X, Thyroxine-Thyroid Hormone Receptor Interactions [gi:61679703]
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6
[SID103570000]
Ki 8e-05Inhibitory activity against [125I]T3 binding to human TRbeta1 receptor [AID213186, Type: Literature]
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7
[SID103570000]
Kd 8.1e-05Displacement of [125I]T3 from human TRbeta receptor [AID323175, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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8
[SID103570000]
Kd 8.7e-05Binding affinity of compound was determined against thyroid hormone receptor beta 1 [AID213185, Type: Literature]
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9
[SID103570000]
Kd 0.0001Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 [AID213172, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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10
[SID103570000]
Kd 0.0001Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 [AID213183, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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11
[SID103570000]
Kd 0.00014Binding affinity towards thyroid hormone receptor (hTR beta 1) [AID213176, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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12
[SID103570000]
Kd 0.00017Binding affinity towards thyroid hormone receptor (hTR alpha 1) [AID213166, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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13
[SID103570000]
Ki 0.00022Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha expressed in sf9 cells by scintillation proximity assay [AID385607, Type: Literature]
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14
[SID103570000]
IC50 0.00024Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 [AID254851, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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15
[SID103570000]
IC50 0.00024Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells [AID299560, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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16
[SID103570000]
IC50 0.000257Inhibition of human thyroid hormone receptor beta 1 [AID299948, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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17
[SID103570000]
IC50 0.00026Binding affinity at human thyroid hormone receptor beta-1 expressed in CHOK1 cells [AID299561, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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18
[SID103570000]
IC50 0.00026Inhibitory concentration against cloned human thyroid hormone receptor beta 1 [AID254845, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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19
[SID103570000]
Ki 0.00033Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay [AID345695, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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20
[SID103570000]
IC50 0.00038Inhibition of rat thyroid hormone receptor [AID566277, Type: Literature]
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