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Pilocarpine (CID 5910) - Compound BioActivity Data
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BioActivity Outcomes:
Active(47)
 
 
Inactive(479)
 
 
Inconclusive(26)
 
 
Unspecified(69)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
 
p450(12)
 
 
 
 
 
PLDc mTdp1 2(9)
 
 
NR LBD VDR(9)
 
 
NR LBD TR(9)
 
 
BioAssay Types:
Confirmatory(399)
 
 
 
 
Literature(157)
 
 
 
 
 
Summary(24)
 
 
Screening(13)
 
 
BioActivity Types:
Potency(382)
 
 
 
 
IC50(18)
 
 
 
Ki(7)
 
 
EC50(3)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 370    Data Row: 621   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177090]
Ki 0.026Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]OXO-M (oxotremorine) as the radioligand. [AID142349, Type: Literature]
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2
[SID103177090]
IC50 0.067In vitro inhibition of [3H]Oxo-Mas binding to M1 and M4 receptors in rat brain homogenate. [AID142501, Type: Literature]
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3
[SID103177090]
IC50 0.068Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand [AID225548, Type: Literature]
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4
[SID103177090]
IC50 0.08Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue. [AID141540, Type: Literature]
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5
[SID103177090]
Ki 0.0829Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranes [AID142081, Type: Literature]
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6
[SID103177090]
IC50 0.96Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. [AID141554, Type: Literature]
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7
[SID103177090]
ED50 1Tested in vitro for agonistic effect on Muscarinic acetylcholine receptor of guinea pig ileum [AID141133, Type: Literature]
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8
[SID103177090]
Ki 1.01Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain. [AID142079, Type: Literature]
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9
[SID103177090]
Ki 1.11The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brain [AID142078, Type: Literature]
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10
[SID103177090]
Ki 3.1Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M1, using [3H]- pirenzepine, a radioligand displacement assay in rat hippocampal membranes [AID141718, Type: confirmatory]
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11
[SID103177090]
Ki 3.67Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-NMS (N-Methylscopolamine) as the radioligand. [AID142348, Type: Literature]
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12
[SID103177090]
IC50 4.43Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 receptors (m1-QNBm1c2) [AID142712, Type: confirmatory]
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13
[SID103177090]
EC50 6.9Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line [AID141319, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:408359949]
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14
[SID103177090]
IC50 7.6Inhibition of specific [3H](R)-QNB binding to Muscarinic acetylcholine receptor in rat brain membranes [AID142488, Type: Literature]
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15
[SID103177090]
IC50 7.6Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranes [AID142711, Type: confirmatory]Muscarinic acetylcholine receptor M2 [gi:12643977]
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16
[SID103177090]
IC50 7.6Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes. [AID104017, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
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17
[SID103177090]
IC50 7.6Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranes [AID142711, Type: confirmatory]Muscarinic acetylcholine receptor M1 [gi:113121]
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18
[SID103177090]
IC50 7.6Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes. [AID104017, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
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19
[SID103177090]
IC50 7.6Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes. [AID104017, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
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20
[SID103177090]
IC50 7.6Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranes [AID142711, Type: confirmatory]Muscarinic acetylcholine receptor M3 [gi:113127]
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