NSC318213 (CID 5897572) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(36)
 
 
Inactive(415)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
Peptidase C48(8)
 
 
 
7TM GPCR Srsx(6)
 
 
alkPPc(6)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(322)
 
 
 
 
Confirmatory(135)
 
 
 
 
 
Literature(7)
 
 
 
BioActivity Types:
Potency(100)
 
 
 
 
 
IC50(27)
 
 
 
 
EC50(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 471    Data Row: 471   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49646548]
Potency 0.3162qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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2
[SID49646548]
Potency 0.3162qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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3
[SID49646548]
Potency 1.6944qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID49646548]
Potency 2.8184qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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5
[SID49646548]
Potency 2.8184qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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6
[SID49646548]
Potency 3.5481qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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7
[SID49646548]
Potency 11.2202qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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8
[SID49646548]
Potency 11.2202qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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9
[SID49646548]
Potency 11.2202qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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10
[SID49646548]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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11
[SID103259533]
IC50 14Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer [AID91426, Type: Literature]Integrase [gi:82312013]
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12
[SID103259533]
IC50 23.9Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing [AID91425, Type: Literature]Integrase [gi:82312013]
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13
[SID49646548]
EC50 24.614Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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14
[SID49646548]
EC50 24.614Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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15
[SID49646548]
Potency 31.6228qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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16
[SID49646548]
EC50 42.851Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA [AID1964, Type: confirmatory]POsterior Segregation family member (pos-1) [Caenorhabditis elegans] [gi:17562800]
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17
[SID49646548]
 Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488912, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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18
[SID49646548]
 HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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19
[SID49646548]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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20
[SID49646548]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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21
[SID49646548]
 uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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22
[SID49646548]
 Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488917, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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23
[SID49646548]
 Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488915, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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24
[SID49646548]
 uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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25
[SID49646548]
 Luminescence-based confirmation biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1846, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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26
[SID49646548]
 Luminescence-based confirmation biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1846, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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27
[SID49646548]
 Luminescence-based confirmation biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1846, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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28
[SID49646548]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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29
[SID49646548]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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30
[SID49646548]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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31
[SID49646548]
 Counterscreen for activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM): Luminescence-based cell-based high throughput screening assay to identify non-selective compounds using the VP16 reporter assay [AID686939, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, i [gi:119579215]
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32
[SID49646548]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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33
[SID49646548]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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34
[SID49646548]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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35
[SID49646548]
 uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase [AID2524, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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36
[SID49646548]
 uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase [AID2524, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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37
[SID49646548]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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38
[SID49646548]
 Luminescence-based counterscreen assay for HSP90 inhibitors: biochemical high throughput screening assay to identify inhibitors of native luciferase. [AID1847, Type: screening]
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39
[SID49646548]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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40
[SID49646548]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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41
[SID49646548]
 Luminescence-based cell-based primary high throughput confirmation assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652260, Type: screening]
View
42
[SID49646548]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]
View
43
[SID49646548]
 Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput screening assay to identify activators of the GAA30 frataxin promoter [AID588350, Type: screening]
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44
[SID49646548]
 Luminescence-based cell-based high throughput confirmation assay for activators of the GAA850 frataxin (FXN) promoter [AID588351, Type: screening]
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45
[SID49646548]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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46
[SID49646548]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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47
[SID49646548]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
48
[SID49646548]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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49
[SID49646548]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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50
[SID49646548]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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