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Estrone (CID 5870) - Compound BioActivity Data
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BioActivity Outcomes:
Active(90)
 
 
Inactive(1225)
 
 
Inconclusive(128)
 
 
Unspecified(344)
 
 
Top Targets:
NR LBD ER(135)
 
 
 
 
 
7TM GPCR Srx(49)
 
 
 
 
7TM GPCR Srsx(40)
 
 
 
NR LBD PPAR(35)
 
 
 
NR LBD AR(24)
 
 
 
 
BioAssay Types:
Confirmatory(656)
 
 
 
 
 
Screening(613)
 
 
 
 
Literature(250)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(632)
 
 
 
 
 
IC50(179)
 
 
 
 
EC50(22)
 
 
 
Ki(3)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1369    Data Row: 1787   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103483583]
EC50 7.72e-05Growth response in cultures of MCF-7 (human breast cancer cell line) cells [AID103554, Type: Literature]
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2
[SID103483583]
EC50 0.0007Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
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3
[SID144208573]
Potency-Replicate_1 0.0014qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144208573]
Ratio Potency (uM) 0.00167429qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID103483583]
EC50 0.0021Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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6
[SID103483583]
Ki 0.003Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+ [AID396108, Type: Literature]
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7
[SID144207116]
Potency-Replicate_1 0.0038qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID144207116]
Ratio Potency (uM) 0.00577522qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID103483583]
Kd 0.00661Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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10
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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12
[SID103483583]
EC50 0.008Activity at human recombinant ERbeta by fluorescence polarization assay [AID440682, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID103483583]
EC50 0.026Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID144213953]
Potency-Replicate_1 0.0268qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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16
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID103483583]
IC50 0.031Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
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18
[SID144213953]
Potency-Replicate_1 0.0477qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID103483583]
ED50 0.051Affinity of compound towards human estrogen receptor alpha [AID70192, Type: Literature]
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20
[SID144213953]
Potency-Replicate_1 0.0535qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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21
[SID144213953]
Potency-Replicate_1 0.054qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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22
[SID144213953]
Potency-Replicate_1 0.06qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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23
[SID103483583]
ED50 0.07Affinity of compound towards human estrogen receptor beta [AID70508, Type: Literature]
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24
[SID103483583]
IC50 0.096Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells [AID467824, Type: Literature]Estrogen receptor [gi:544257]
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25
[SID103483583]
IC50 0.109Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintillation counting [AID467823, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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26
[SID103483583]
EC50 0.12Ability to activate estrogen receptor 1-mediated transcription. [AID70185, Type: Literature]
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27
[SID103483583]
EC50 0.12Ability to activate estrogen receptor 2-mediated transcription. [AID70504, Type: Literature]
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28
[SID144213953]
Potency-Replicate_1 0.1508qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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29
[SID103483583]
EC50 0.166Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM [AID262955, Type: Literature]Estrogen receptor beta [gi:6166154]
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30
[SID103483583]
IC50 0.21Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement. [AID70200, Type: Literature]
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31
[SID144213953]
Potency-Replicate_1 0.213qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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32
[SID103483583]
IC50 0.218Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogen [AID320275, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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33
[SID103483583]
IC50 0.33Inhibition of 17-beta HSD1 in T47D cells [AID260452, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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34
[SID144213953]
Potency-Replicate_1 0.3788qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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35
[SID103483583]
EC50 0.48Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor alpha. [AID70191, Type: Literature]
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36
[SID144213953]
Potency-Replicate_1 0.5351qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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37
[SID103483583]
IC50 0.54Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement. [AID70515, Type: Literature]
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38
[SID103483583]
IC50 0.6Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol [AID396111, Type: Literature]
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39
[SID103483583]
IC50 0.81Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH [AID396110, Type: Literature]
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40
[SID103483583]
EC50 1.135Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta. [AID70507, Type: Literature]
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41
[SID144213953]
AR Potency (uM) 1.2835qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
42
[SID144208573]
Potency-Replicate_1 1.7246qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
43
[SID144208573]
Ratio Potency (uM) 1.95177qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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44
[SID144208573]
Potency-Replicate_1 3.8943qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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45
[SID103483583]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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46
[SID50104169]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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47
[SID144207116]
Potency-Replicate_1 4.2163qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID56423156]
Potency 4.4668qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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49
[SID144207116]
Ratio Potency (uM) 4.59192qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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50
[SID103483583]
Km 4.6Activity of 17beta-HSD1 [AID320283, Type: Literature]
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