Estrone (CID 5870) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(49)
 
 
Inactive(956)
 
 
Inconclusive(49)
 
 
Unspecified(297)
 
 
Top Targets:
NR LBD ER(65)
 
 
 
 
 
7TM GPCR Srx(36)
 
 
 
7TM GPCR Srsx(22)
 
 
 
 
Tryp SPc(15)
 
 
 
 
alkPPc(14)
 
 
BioAssay Types:
Screening(552)
 
 
 
 
Confirmatory(412)
 
 
 
 
 
Literature(198)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(343)
 
 
 
 
 
IC50(174)
 
 
 
 
EC50(22)
 
 
 
Ki(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1231    Data Row: 1351   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103483583]
EC50 7.72e-05Growth response in cultures of MCF-7 (human breast cancer cell line) cells [AID103554, Type: Literature]
View
2
[SID103483583]
EC50 0.0007Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
View
3
[SID103483583]
EC50 0.0021Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
View
4
[SID103483583]
Ki 0.003Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+ [AID396108, Type: Literature]
View
5
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
View
6
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
View
7
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
View
8
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
View
9
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
View
10
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
View
11
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
View
12
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
View
13
[SID103483583]
EC50 0.008Activity at human recombinant ERbeta by fluorescence polarization assay [AID440682, Type: Literature]Estrogen receptor beta [gi:6166154]
View
14
[SID103483583]
EC50 0.008Activity at human recombinant ERbeta by fluorescence polarization assay [AID440682, Type: Literature]Estrogen receptor beta [gi:6166154]
View
15
[SID103483583]
EC50 0.008Activity at human recombinant ERbeta by fluorescence polarization assay [AID440682, Type: Literature]Estrogen receptor beta [gi:6166154]
View
16
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
17
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
18
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
19
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
20
[SID103483583]
EC50 0.026Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
View
21
[SID103483583]
EC50 0.026Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
View
22
[SID103483583]
EC50 0.026Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
View
23
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
View
24
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
View
25
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
View
26
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
View
27
[SID103483583]
IC50 0.031Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
View
28
[SID103483583]
IC50 0.031Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
View
29
[SID103483583]
IC50 0.031Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
View
30
[SID103483583]
ED50 0.051Affinity of compound towards human estrogen receptor alpha [AID70192, Type: Literature]
View
31
[SID103483583]
ED50 0.07Affinity of compound towards human estrogen receptor beta [AID70508, Type: Literature]
View
32
[SID103483583]
IC50 0.096Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells [AID467824, Type: Literature]Estrogen receptor [gi:544257]
View
33
[SID103483583]
IC50 0.096Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells [AID467824, Type: Literature]Estrogen receptor [gi:544257]
View
34
[SID103483583]
IC50 0.096Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells [AID467824, Type: Literature]Estrogen receptor [gi:544257]
View
35
[SID103483583]
IC50 0.096Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells [AID467824, Type: Literature]Estrogen receptor [gi:544257]
View
36
[SID103483583]
IC50 0.109Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintillation counting [AID467823, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
View
37
[SID103483583]
EC50 0.12Ability to activate estrogen receptor 1-mediated transcription. [AID70185, Type: Literature]
View
38
[SID103483583]
EC50 0.12Ability to activate estrogen receptor 2-mediated transcription. [AID70504, Type: Literature]
View
39
[SID103483583]
EC50 0.166Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM [AID262955, Type: Literature]Estrogen receptor beta [gi:6166154]
View
40
[SID103483583]
EC50 0.166Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM [AID262955, Type: Literature]Estrogen receptor beta [gi:6166154]
View
41
[SID103483583]
EC50 0.166Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM [AID262955, Type: Literature]Estrogen receptor beta [gi:6166154]
View
42
[SID103483583]
IC50 0.21Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement. [AID70200, Type: Literature]
View
43
[SID103483583]
IC50 0.218Inhibition of 17beta-HSD1 in human T47D cells assessed as inhibition of transformation of [14C]-estrone into [14C]estrogen [AID320275, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
View
44
[SID103483583]
IC50 0.33Inhibition of 17-beta HSD1 in T47D cells [AID260452, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
View
45
[SID103483583]
EC50 0.48Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor alpha. [AID70191, Type: Literature]
View
46
[SID103483583]
IC50 0.54Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement. [AID70515, Type: Literature]
View
47
[SID103483583]
IC50 0.6Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol [AID396111, Type: Literature]
View
48
[SID103483583]
IC50 0.81Inhibition of 17beta-HSD1 expressed in HEK 293 cells assessed as conversion of [14C]estrone to [14C]estradiol using NADH [AID396110, Type: Literature]
View
49
[SID103483583]
EC50 1.135Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta. [AID70507, Type: Literature]
View
50
[SID103483583]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View