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Estrone (CID 5870) - Compound BioActivity Data
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BioActivity Outcomes:
Active(86)
 
 
Inactive(1253)
 
 
Inconclusive(119)
 
 
Unspecified(344)
 
 
Top Targets:
NR LBD ER(135)
 
 
 
 
 
7TM GPCR Srx(49)
 
 
 
 
7TM GPCR Srsx(40)
 
 
 
NR LBD PPAR(35)
 
 
 
NR LBD AR(24)
 
 
 
 
BioAssay Types:
Confirmatory(774)
 
 
 
 
 
Screening(615)
 
 
 
 
Literature(276)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(635)
 
 
 
 
 
IC50(179)
 
 
 
 
EC50(22)
 
 
 
Ki(3)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1370    Data Row: 1802   Total Pages: 91   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103483583]
EC50 7.72e-05Growth response in cultures of MCF-7 (human breast cancer cell line) cells [AID103554, Type: Literature]
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2
[SID103483583]
EC50 0.0007Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
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3
[SID144208573]
Potency-Replicate_1 0.0014qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144208573]
Ratio Potency (uM) 0.00167429qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID103483583]
EC50 0.0021Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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6
[SID103483583]
Ki 0.003Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+ [AID396108, Type: Literature]
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7
[SID144207116]
Potency-Replicate_1 0.0038qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID144207116]
Ratio Potency (uM) 0.00577522qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID103483583]
Kd 0.00661Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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10
[SID103483583]
EC50 0.007Activity at human recombinant ERalpha by fluorescence polarization assay [AID440681, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103483583]
IC50 0.00765DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: confirmatory]Estrogen receptor [gi:544257]
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12
[SID103483583]
EC50 0.008Activity at human recombinant ERbeta by fluorescence polarization assay [AID440682, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID26751562]
Potency 0.0112qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID103483583]
EC50 0.026Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay [AID262953, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID144213953]
Potency-Replicate_1 0.0268qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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16
[SID103483583]
IC50 0.029Displacement of [3H]estrone from ER alpha [AID262950, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID103483583]
IC50 0.031Displacement of [3H]estrone from ER beta [AID262948, Type: Literature]Estrogen receptor beta [gi:6166154]
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18
[SID144213953]
Potency-Replicate_1 0.0477qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID103483583]
ED50 0.051Affinity of compound towards human estrogen receptor alpha [AID70192, Type: Literature]
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20
[SID144213953]
Potency-Replicate_1 0.0535qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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