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Cysteine (CID 5862) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(1)
 
 
Unspecified(33)
 
 
Top Targets:
Aa trans(7)
 
 
 
SATase N(1)
 
 
MFS(1)
 
 
PBPb(1)
 
 
BioAssay Types:
Literature(40)
 
 
 
 
BioActivity Types:
IC50(5)
 
 
Ki(4)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 42    Data Row: 43   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103224626]
EC50 20Concentration required for obtaining 50% of the fluorescence intensity of copper-free calcein 1, in bovine serum albumin [AID51033, Type: Literature]
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2
[SID48415836]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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3
[SID103224626]
Antioxidant activity assessed as ABTS radical scavenging activity at 4 uM after 3 mins in presence of Cu2+ [AID390226, Type: Literature]
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4
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 36 uM after 3 mins in presence of Cu2++ [AID390227, Type: Literature]
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5
[SID103224626]
Induction of H2S production measured every 15 sec to 1 min by thiobimane fluorescent method [AID695527, Type: Literature]
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6
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM [AID701010, Type: Literature]
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7
[SID103224626]
Effect on CU2+-mediated superoxide-dependent cytochrome c reduction at 10 to 30 uM [AID390220, Type: Literature]
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8
[SID46393167]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Serine Acetyltransferase- Complex With Cysteine [gi:49259141]
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9
[SID46393595]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Cysteine-Binding Protein From Campylobacter Jejuni At 2.0 A Resolution [gi:75765505]
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10
[SID103224626]
IC50 50Cytotoxic activity against HeLa cells [AID299461, Type: Literature]
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11
[SID103224626]
Ki 59Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation counting [AID456220, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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12
[SID103224626]
IC50 63Inhibition of Eg5 assessed as inhibition ATP hydrolysis by ATPase assay [AID299460, Type: Literature]
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13
[SID103224626]
IC50 116Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting [AID456221, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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14
[SID103224626]
IC50 322Inhibition of desert banana tyrosinase using p-cresol as substrate [AID657488, Type: Literature]
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15
[SID103224626]
Ki 350Inhibition of bovine carboxypeptidase A (CPA) using hippuryl-L-phenylalanine (Hipp-L-Phe) as a substrate. [AID48474, Type: Literature]
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16
[SID103224626]
IC50 748Inhibition of phosphodiesterase-1 [AID378146, Type: Literature]
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17
[SID103224626]
Ki 46000Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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18
[SID103224626]
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake at 500 uM after 24 hrs by liquid scintillation counting [AID475771, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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19
[SID103224626]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: other]Monocarboxylate transporter 10 [gi:81871541]
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20
[SID103224626]
Antioxidant activity assessed as reducing capacity of DTNB at 20 uM after 30 mins in presence of Cu2++ [AID390209, Type: Literature]
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21
[SID103224626]
Antioxidant activity assessed as reducing capacity of Iodine solution at 0.25mM after 30 mins in presence of Cu2++ [AID390210, Type: Literature]
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22
[SID103224626]
Antioxidant activity assessed as ABTS radical scavenging activity at 4 uM after 30 mins in presence of Cu2++ [AID390211, Type: Literature]
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23
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 36 uM after 30 mins in presence of Cu2++ [AID390212, Type: Literature]
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24
[SID103224626]
Induction of ascorbic acid oxidation preincubated for 3 mins in presence of Cu2++ [AID390216, Type: Literature]
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25
[SID103224626]
Induction of ascorbic acid oxidation preincubated for 30 mins in presence of Cu2++ [AID390217, Type: Literature]
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26
[SID103224626]
Induction of ascorbic acid oxidation preincubated for 60 mins in presence of Cu2++ [AID390218, Type: Literature]
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27
[SID103224626]
Induction of ascorbic acid oxidation preincubated for 300 mins in presence of Cu2++ [AID390219, Type: Literature]
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28
[SID103224626]
Evaluated for its intraperitoneally to mice [AID117055, Type: Literature]
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29
[SID103224626]
Bitter threshold value of the compound; S denotes 'Sulfurous' [AID233322, Type: Literature]
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30
[SID103224626]
Effect of compound on gelation time of human serum induced by dithiothreitol (DTT) [AID7789, Type: other]
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31
[SID103224626]
pKa value was determined [AID26336, Type: Literature]
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32
[SID103224626]
Partition coefficient (logP) [AID26797, Type: Literature]
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33
[SID103224626]
Antioxidant activity assessed as ABTS radical scavenging activity after 30 mins in absence of Cu2+ [AID390224, Type: Literature]
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34
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity after 40 mins in absence of Cu2+ [AID390225, Type: Literature]
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35
[SID103224626]
Inhibition of cystine/glutamate transporter in human SNB19 cells assessed as [3H]glutamate uptake at 500 uM [AID628028, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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36
[SID103224626]
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake at 500 uM by liquid scintillation counting [AID456218, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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37
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 20 uM after 30 mins [AID376397, Type: Literature]
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38
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 40 uM after 30 mins [AID376398, Type: Literature]
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39
[SID103224626]
Antioxidant activity assessed as DPPH radical scavenging activity at 80 uM after 30 mins [AID376399, Type: Literature]
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40
[SID103224626]
Dissociation constant, pKa of the compound [AID410195, Type: Literature]
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41
[SID103224626]
Inhibition of alpha-dicarbonyls-induced advanced glycation endproduct formation assessed as protection against 50 eq. MG-induced insulin degradation at 3.75 mM after 24 hrs by RP-HPLC [AID450158, Type: Literature]
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42
[SID103224626]
Inhibition of VGLUT in rat synaptic vesicles assessed as glutamate uptake at 5 mM relative to control [AID628027, Type: Literature]
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43
[SID103224626]
Activity at amino acid transport system xc- in human SNB19 cells assessed as induction of L-glutamate efflux at 500 uM by fluorometric assay [AID456224, Type: Literature]Cystine/glutamate transporter [gi:12585385]
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