Aldosterone (CID 5839) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(466)
 
 
Inconclusive(12)
 
 
Unspecified(51)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
NR LBD MR(9)
 
 
 
NR LBD PPAR(8)
 
 
 
 
7TM GPCR Srsx(6)
 
 
NR LBD RXR li..(6)
 
 
 
BioAssay Types:
Screening(360)
 
 
 
 
Confirmatory(119)
 
 
 
 
 
Literature(51)
 
 
 
 
BioActivity Types:
Potency(104)
 
 
 
 
 
IC50(15)
 
 
 
 
EC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 479    Data Row: 553   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174056]
EC50 0.0038Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay [AID469722, Type: Literature]
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2
[SID103174056]
IC50 0.00927Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517034, Type: Literature]Mineralocorticoid receptor [gi:126885]
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3
[SID103174056]
IC50 0.00927Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517034, Type: Literature]Mineralocorticoid receptor [gi:126885]
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4
[SID103174056]
IC50 0.043Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting [AID578356, Type: Literature]Mineralocorticoid receptor [gi:126886]
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5
[SID103174056]
IC50 0.043Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting [AID626477, Type: Literature]Mineralocorticoid receptor [gi:126886]
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6
[SID26757653]
Potency 15.8489qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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7
[SID26757653]
Potency 15.8489qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_41, Type: screening]progesterone receptor isoform B [Homo sapiens] [gi:110611914]
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9
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_41, Type: screening]progesterone receptor isoform B [Homo sapiens] [gi:110611914]
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10
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_8, Type: screening]hepatocyte nuclear factor 4-gamma [Homo sapiens] [gi:115583654]
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11
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_8, Type: screening]hepatocyte nuclear factor 4-gamma [Homo sapiens] [gi:115583654]
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12
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_29, Type: screening]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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13
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_29, Type: screening]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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14
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_19, Type: screening]nuclear receptor subfamily 2 group C member 1 isoform c [Homo sapiens] [gi:189491766]
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15
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_19, Type: screening]nuclear receptor subfamily 2 group C member 1 isoform c [Homo sapiens] [gi:189491766]
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16
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_6, Type: screening]estrogen-related receptor gamma isoform 2 [Homo sapiens] [gi:197209821]
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17
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_6, Type: screening]estrogen-related receptor gamma isoform 2 [Homo sapiens] [gi:197209821]
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18
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277, Type: screening]AR protein [Homo sapiens] [gi:124375976]
View
19
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277, Type: screening]AR protein [Homo sapiens] [gi:124375976]
View
20
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_12, Type: screening]nuclear receptor subfamily 1 group D member 1 [Homo sapiens] [gi:13430848]
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21
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_12, Type: screening]nuclear receptor subfamily 1 group D member 1 [Homo sapiens] [gi:13430848]
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22
[SID48415527]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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23
[SID56320630]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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24
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_53, Type: screening]nuclear receptor ROR-beta [Homo sapiens] [gi:19743907]
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25
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_53, Type: screening]nuclear receptor ROR-beta [Homo sapiens] [gi:19743907]
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26
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_36, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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27
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_36, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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28
[SID103174056]
 Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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29
[SID103174056]
 Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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30
[SID103174056]
 Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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31
[SID103174056]
 Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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32
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_54, Type: screening]nuclear receptor ROR-gamma isoform b [Homo sapiens] [gi:48255918]
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33
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_54, Type: screening]nuclear receptor ROR-gamma isoform b [Homo sapiens] [gi:48255918]
View
34
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_42, Type: screening]peroxisome proliferator-activated receptor alpha [Homo sapiens] [gi:50348666]
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35
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_42, Type: screening]peroxisome proliferator-activated receptor alpha [Homo sapiens] [gi:50348666]
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36
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_30, Type: screening]mineralocorticoid receptor isoform 2 [Homo sapiens] [gi:260656020]
View
37
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_30, Type: screening]mineralocorticoid receptor isoform 2 [Homo sapiens] [gi:260656020]
View
38
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_56, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
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39
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_56, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
View
40
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_57, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
View
41
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_57, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
View
42
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_33, Type: screening]nuclear receptor subfamily 4 group A member 2 [Homo sapiens] [gi:5453822]
View
43
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_33, Type: screening]nuclear receptor subfamily 4 group A member 2 [Homo sapiens] [gi:5453822]
View
44
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_38, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
View
45
[SID87219227]
 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_38, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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46
[SID103174056]
Km 0.015TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681606, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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47
[SID103174056]
IC50 42.6579Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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48
[SID103174056]
 Permeability across porcine brain lipid coated polyvinylidenefluoride membrane by PAMPA [AID349880, Type: Literature]
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49
[SID103174056]
 Permeability coefficient in human skin [AID311367, Type: Literature]
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50
[SID103174056]
 Binding affinity against human monoclonal antibody (mAb)-5C2 [AID127351, Type: Literature]
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