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Aldosterone (CID 5839) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(539)
 
 
Inconclusive(13)
 
 
Unspecified(51)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(12)
 
 
NR LBD MR(9)
 
 
 
NR LBD PPAR(8)
 
 
 
 
NR LBD RAR(6)
 
 
BioAssay Types:
Screening(410)
 
 
 
 
Confirmatory(143)
 
 
 
 
 
Literature(51)
 
 
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(15)
 
 
 
 
EC50(5)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 517    Data Row: 629   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174056]
EC50 0.000338Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517027, Type: Literature]Mineralocorticoid receptor [gi:126885]
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2
[SID103174056]
EC50 0.0038Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay [AID469722, Type: Literature]
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3
[SID103174056]
IC50 0.00927Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517034, Type: Literature]Mineralocorticoid receptor [gi:126885]
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4
[SID103174056]
IC50 0.043Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting [AID578356, Type: Literature]Mineralocorticoid receptor [gi:126886]
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5
[SID103174056]
IC50 0.043Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting [AID626477, Type: Literature]Mineralocorticoid receptor [gi:126886]
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6
[SID103174056]
Kd 4.7863Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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7
[SID26757653]
Potency 15.8489qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_42, Type: screening]peroxisome proliferator-activated receptor alpha [Homo sapiens] [gi:50348666]
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9
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_19, Type: screening]nuclear receptor subfamily 2 group C member 1 isoform c [Homo sapiens] [gi:189491766]
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10
[SID103174056]
Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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11
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_54, Type: screening]nuclear receptor ROR-gamma isoform b [Homo sapiens] [gi:48255918]
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12
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_41, Type: screening]progesterone receptor isoform B [Homo sapiens] [gi:110611914]
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13
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_8, Type: screening]hepatocyte nuclear factor 4-gamma [Homo sapiens] [gi:115583654]
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14
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_6, Type: screening]estrogen-related receptor gamma isoform 2 [Homo sapiens] [gi:197209821]
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15
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_30, Type: screening]mineralocorticoid receptor isoform 2 [Homo sapiens] [gi:260656020]
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16
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_12, Type: screening]nuclear receptor subfamily 1 group D member 1 [Homo sapiens] [gi:13430848]
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17
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_53, Type: screening]nuclear receptor ROR-beta [Homo sapiens] [gi:19743907]
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18
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_29, Type: screening]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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19
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_38, Type: screening]nuclear receptor subfamily 5 group A member 2 isoform 2 [Homo sapiens] [gi:4504343]
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20
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_56, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
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21
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_57, Type: screening]retinoic acid receptor RXR-alpha [Homo sapiens] [gi:4506755]
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22
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_33, Type: screening]nuclear receptor subfamily 4 group A member 2 [Homo sapiens] [gi:5453822]
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23
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_36, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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24
[SID48415527]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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25
[SID56320630]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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26
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277, Type: screening]
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27
[SID103174056]
Km 0.015TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681606, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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28
[SID103174056]
IC50 42.658Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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29
[SID103174056]
Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr [AID126435, Type: Literature]
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30
[SID103174056]
Ratio of [3H]aldosterone binding with 8*10e-8 M aldosterone to [3H]aldosterone binding with 8*10e-8 M competitor at Mineralocorticoid receptor [AID126437, Type: Literature]
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31
[SID103174056]
Permeability coefficient in human skin [AID311367, Type: Literature]
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32
[SID103174056]
Permeability across porcine brain lipid coated polyvinylidenefluoride membrane by PAMPA [AID349880, Type: Literature]
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33
[SID103174056]
Diffusion constant for permeability of stratum corneum [AID23943, Type: Literature]
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34
[SID103174056]
Relative binding affinity for androgen receptor of prostate of rat at 2 hr [AID39320, Type: Literature]
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35
[SID103174056]
Binding affinity for corticosteroid binding globulin is expressed as log(1/k) [AID51054, Type: Literature]
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36
[SID103174056]
Binding affinity to human CBG receptor (corticosteroid-binding globulins) [AID51055, Type: Literature]
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37
[SID103174056]
Binding affinity towards corticosteroid binding globulin (CBG) [AID51057, Type: Literature]
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38
[SID103174056]
Binding affinity to corticosteroid binding globulin [AID51059, Type: Literature]
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39
[SID103174056]
Binding affinity to the corticosteroid-binding globulin (CBG) receptor. [AID53796, Type: Literature]
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40
[SID103174056]
Displacement of [3H]dexamethasone from Glucocorticoid receptor of rabbit kidney [AID74244, Type: Literature]
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41
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 24 hr [AID74373, Type: Literature]
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42
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 4 hr [AID74374, Type: Literature]
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43
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from liver at 24 hr [AID74375, Type: Literature]
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44
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from liver at 4 hr [AID74376, Type: Literature]
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45
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 24 hr [AID74377, Type: Literature]
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46
[SID103174056]
Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 4 hr [AID74378, Type: Literature]
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47
[SID103174056]
Displacement of [3H]aldosterone from mineralocorticoid receptor of rabbit kidney [AID126285, Type: Literature]
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48
[SID103174056]
Displacement of [3H]aldosterone from mineralocorticoid receptor [AID126297, Type: Literature]
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49
[SID103174056]
Binding affinity against human monoclonal antibody (mAb)-11E6 [AID127349, Type: other]
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50
[SID103174056]
Binding affinity against human monoclonal antibody (mAb)-5C2 [AID127351, Type: Literature]
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