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Aldosterone (CID 5839) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(546)
 
 
Inconclusive(13)
 
 
Unspecified(224)
 
 
Top Targets:
7tm 4(32)
 
 
NR LBD MR(9)
 
 
 
NR LBD PPAR(8)
 
 
 
 
NR LBD TR(6)
 
 
 
NR LBD RXR li..(6)
 
 
 
BioAssay Types:
Screening(411)
 
 
 
 
Confirmatory(143)
 
 
 
 
 
Literature(68)
 
 
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(15)
 
 
 
 
EC50(5)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 691    Data Row: 809   Total Pages: 41   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174056]
EC50 0.000338Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517027, Type: Literature]Mineralocorticoid receptor [gi:126885]
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2
[SID103174056]
EC50 0.0038Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay [AID469722, Type: Literature]
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3
[SID103174056]
IC50 0.00927Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517034, Type: Literature]Mineralocorticoid receptor [gi:126885]
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4
[SID103174056]
IC50 0.043Displacement of [3H]aldosterone from Sprague-Dawley rat MR by liquid scintillation counting [AID578356, Type: Literature]Mineralocorticoid receptor [gi:126886]
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5
[SID103174056]
IC50 0.043Displacement of [3H]Aldo from mineralocorticoid receptor in Sprague-Dawley rat kidney after 2 hrs by liquid scintillation counting [AID626477, Type: Literature]Mineralocorticoid receptor [gi:126886]
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6
[SID103174056]
Kd 4.7863Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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7
[SID26757653]
Potency 15.8489qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_6, Type: screening]estrogen-related receptor gamma isoform 2 [Homo sapiens] [gi:197209821]
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9
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_41, Type: screening]progesterone receptor isoform B [Homo sapiens] [gi:110611914]
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10
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_19, Type: screening]nuclear receptor subfamily 2 group C member 1 isoform c [Homo sapiens] [gi:189491766]
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11
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_8, Type: screening]hepatocyte nuclear factor 4-gamma [Homo sapiens] [gi:115583654]
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12
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_30, Type: screening]mineralocorticoid receptor isoform 2 [Homo sapiens] [gi:260656020]
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13
[SID103174056]
Inhibition of MR-mediated transactivation of galactosidase reporter gene in HEK293 cells expressing 11betaHSD1 [AID266004, Type: Literature]Glucocorticoid receptor [gi:121069]
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14
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_38, Type: screening]nuclear receptor subfamily 5 group A member 2 isoform 2 [Homo sapiens] [gi:4504343]
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15
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_56, Type: screening]retinoic acid receptor RXR-alpha isoform a [Homo sapiens] [gi:4506755]
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16
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_57, Type: screening]retinoic acid receptor RXR-alpha isoform a [Homo sapiens] [gi:4506755]
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17
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_33, Type: screening]nuclear receptor subfamily 4 group A member 2 [Homo sapiens] [gi:5453822]
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18
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_36, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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19
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_12, Type: screening]nuclear receptor subfamily 1 group D member 1 [Homo sapiens] [gi:13430848]
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20
[SID87219227]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_53, Type: screening]nuclear receptor ROR-beta [Homo sapiens] [gi:19743907]
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