2uzo (CID 5828196) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(433)
 
 
Inconclusive(19)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(6)
 
 
alkPPc(6)
 
 
 
PKc like(5)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(319)
 
 
 
 
Confirmatory(141)
 
 
 
 
 
Literature(8)
 
 
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(26)
 
 
 
EC50(9)
 
 
 
AC50(6)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 471    Data Row: 471   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50085448]
EC50 0.23715Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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2
[SID50085448]
EC50 0.23715Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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3
[SID50085448]
EC50 0.23715Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
4
[SID50085448]
AC50 5.292Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha [AID463203, Type: confirmatory]GSK3A gene product [Homo sapiens] [gi:49574532]
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5
[SID50085448]
AC50 5.292Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha [AID463203, Type: confirmatory]GSK3A gene product [Homo sapiens] [gi:49574532]
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6
[SID50085448]
Potency 11.5821Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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7
[SID50085448]
Potency 13.4591qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID103535070]
IC50 27Inhibition of CDK2 [AID299679, Type: Literature]
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9
[SID50085448]
EC50 33.379Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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10
[SID50085448]
EC50 33.379Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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11
[SID50085448]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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12
[SID50085448]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
View
13
[SID50085448]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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14
[SID50085448]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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15
[SID50085448]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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16
[SID50085448]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
17
[SID50085448]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
18
[SID50085448]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
19
[SID50085448]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
20
[SID50085448]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
21
[SID50085448]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
22
[SID50085448]
 Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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23
[SID53813040]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Human Cdk2 Complexed With A Thiazolidinone Inhibitor [gi:151568095]
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24
[SID50085448]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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25
[SID50085448]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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26
[SID50085448]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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27
[SID50085448]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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28
[SID50085448]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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29
[SID50085448]
 uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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30
[SID50085448]
 Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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31
[SID50085448]
 Single concentration confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID434971, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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32
[SID103535070]
GI50 80Antiproliferative activity against HCT116 cells by SRB assay after 72 hrs [AID299684, Type: Literature]
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33
[SID50085448]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID50085448]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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35
[SID50085448]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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36
[SID50085448]
Potency 31.6228qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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37
[SID50085448]
Potency 31.6228Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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38
[SID50085448]
Potency 31.6228Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
39
[SID50085448]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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40
[SID50085448]
EC50 110Luminescence-based Microorganism Dose Response HTS to Identify Inhibitors of E. Coli Growth [AID1959, Type: confirmatory]
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41
[SID50085448]
EC50 116.217Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) [AID463086, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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42
[SID50085448]
EC50 116.217Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) [AID463086, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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43
[SID50085448]
EC50 300Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA [AID1964, Type: confirmatory]POsterior Segregation family member (pos-1) [Caenorhabditis elegans] [gi:17562800]
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44
[SID50085448]
AC50 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo [AID463205, Type: confirmatory]
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45
[SID50085448]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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46
[SID50085448]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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47
[SID50085448]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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48
[SID50085448]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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49
[SID50085448]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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50
[SID50085448]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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