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Epinephrine (CID 5816) - Compound BioActivity Data
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BioActivity Outcomes:
Active(106)
 
 
Inactive(444)
 
 
Inconclusive(72)
 
 
Unspecified(309)
 
 
Top Targets:
7TM GPCR Srx(38)
 
 
 
 
 
7TM GPCR Srsx(34)
 
 
 
 
p450(21)
 
 
 
 
 
NR LBD PPAR(13)
 
 
 
NR LBD TR(13)
 
 
 
BioAssay Types:
Confirmatory(543)
 
 
 
 
 
Literature(196)
 
 
 
 
 
Summary(24)
 
 
 
Screening(13)
 
 
 
BioActivity Types:
Potency(415)
 
 
 
 
IC50(119)
 
 
 
Ki(22)
 
 
 
EC50(15)
 
 
Kd(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 688    Data Row: 931   Total Pages: 47   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103190535]
Ki 0.005Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidine [AID36054, Type: Literature]
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2
[SID103190535]
IC50 0.008Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes [AID36188, Type: Literature]
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3
[SID103190535]
Ki 0.013Binding of [3H]clonidine to alpha-2-adrenergic receptor of rat cerebral cortical membranes [AID219797, Type: Literature]
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4
[SID103190535]
EC50 0.015Effective dose required to stimulate contractions in isolated guinea pig atrium. [AID42053, Type: Literature]
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5
[SID103190535]
EC50 0.015Effective dose for relaxation of guinea pig trachea. [AID40846, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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6
[SID103190535]
IC50 0.017Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenate [AID33129, Type: Literature]
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7
[SID103190535]
EC50 0.031Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method [AID326592, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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8
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2A adrenergic receptor [gi:231461]
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9
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2C adrenergic receptor [gi:231464]
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10
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2B adrenergic receptor [gi:47117345]
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11
[SID103190535]
EC50 0.049Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay [AID326595, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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12
[SID103190535]
Ki 0.1Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513154, Type: Literature]
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13
[SID103190535]
Ki 0.11Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513146, Type: Literature]
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14
[SID103190535]
Ki 0.16Displacement of radioligand from rat alpha2 adrenergic receptor by liquid scintillation spectrometry [AID401519, Type: Literature]
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15
[SID90341589]
Potency 0.1636HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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16
[SID103190535]
Ki 0.2Compound was evaluated for inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat forebrain homogenate. [AID37468, Type: Literature]
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17
[SID103190535]
EC50 0.23Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells [AID41600, Type: Literature]
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18
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-3 adrenergic receptor [gi:543882]
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19
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-1 adrenergic receptor [gi:114754]
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20
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-2 adrenergic receptor [gi:114768]
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