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Epinephrine (CID 5816) - Compound BioActivity Data
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BioActivity Outcomes:
Active(105)
 
 
Inactive(438)
 
 
Inconclusive(76)
 
 
Unspecified(202)
 
 
Top Targets:
7TM GPCR Srx(38)
 
 
 
 
 
7TM GPCR Srsx(33)
 
 
 
 
p450(21)
 
 
 
 
 
NR LBD PPAR(13)
 
 
 
NR LBD TR(13)
 
 
 
BioAssay Types:
Confirmatory(425)
 
 
 
 
Literature(189)
 
 
 
 
 
Summary(24)
 
 
 
Screening(13)
 
 
 
BioActivity Types:
Potency(413)
 
 
 
 
IC50(119)
 
 
 
Ki(22)
 
 
 
EC50(15)
 
 
Kd(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 579    Data Row: 821   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103190535]
Ki 0.005Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidine [AID36054, Type: Literature]
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2
[SID103190535]
IC50 0.008Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes [AID36188, Type: Literature]
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3
[SID103190535]
Ki 0.013Binding of [3H]clonidine to alpha-2-adrenergic receptor of rat cerebral cortical membranes [AID219797, Type: Literature]
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4
[SID103190535]
EC50 0.015Effective dose required to stimulate contractions in isolated guinea pig atrium. [AID42053, Type: Literature]
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5
[SID103190535]
EC50 0.015Effective dose for relaxation of guinea pig trachea. [AID40846, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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6
[SID103190535]
IC50 0.017Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenate [AID33129, Type: Literature]
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7
[SID103190535]
EC50 0.031Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method [AID326592, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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8
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2A adrenergic receptor [gi:231461]
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9
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2C adrenergic receptor [gi:231464]
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10
[SID103190535]
Ki 0.038Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes [AID32956, Type: Literature]Alpha-2B adrenergic receptor [gi:47117345]
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11
[SID103190535]
EC50 0.049Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay [AID326595, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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12
[SID103190535]
Ki 0.1Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513154, Type: Literature]
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13
[SID103190535]
Ki 0.11Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513146, Type: Literature]
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14
[SID103190535]
Ki 0.16Displacement of radioligand from rat alpha2 adrenergic receptor by liquid scintillation spectrometry [AID401519, Type: Literature]
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15
[SID90341589]
Potency 0.1636HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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16
[SID103190535]
Ki 0.2Compound was evaluated for inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat forebrain homogenate. [AID37468, Type: Literature]
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17
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-1 adrenergic receptor [gi:114754]
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18
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-2 adrenergic receptor [gi:114768]
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19
[SID103190535]
EC50 0.23Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells [AID41600, Type: Literature]
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20
[SID103190535]
EC50 0.23Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor [AID44627, Type: Literature]Beta-3 adrenergic receptor [gi:543882]
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21
[SID103190535]
IC50 0.232DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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22
[SID103190535]
EC50 0.26Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria [AID42049, Type: Literature]
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23
[SID103190535]
IC50 0.284DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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24
[SID103190535]
EC50 0.3Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membranes [AID36352, Type: Literature]Alpha-2A adrenergic receptor [gi:1351829]
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25
[SID103190535]
EC50 0.3Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membranes [AID36352, Type: Literature]Alpha-2C adrenergic receptor [gi:20141211]
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26
[SID103190535]
EC50 0.3Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membranes [AID36352, Type: Literature]Alpha-2B adrenergic receptor [gi:27151763]
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27
[SID103190535]
EC50 0.4Effective concentration for stimulation of [3H]phosphoinositide formation in guinea pig synaptoneurosomes expressing alpha-1 receptor [AID73730, Type: Literature]
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28
[SID103190535]
EC50 0.4Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex [AID35994, Type: Literature]
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29
[SID103190535]
IC50 0.449DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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30
[SID103190535]
IC50 0.628DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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31
[SID103190535]
Kd 0.63Binding affinity to human adrenergic beta2 receptor [AID426242, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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32
[SID103190535]
Ki 0.66Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes [AID41478, Type: Literature]
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33
[SID103190535]
Ki 0.72Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes [AID33079, Type: Literature]Beta-2 adrenergic receptor [gi:114768]
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34
[SID103190535]
IC50 0.737DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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35
[SID11111154]
Potency 0.7943qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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36
[SID11111154]
Potency 0.7943qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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37
[SID103190535]
IC50 0.869DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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38
[SID103190535]
Ki 1.1Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes [AID40408, Type: Literature]
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39
[SID103190535]
Ki 1.2Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes [AID33078, Type: Literature]Beta-1 adrenergic receptor [gi:114754]
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40
[SID11111154]
Potency 1.5849qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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41
[SID103190535]
Ki 1.6Binding of [3H]prazosin to alpha-1 adrenergic receptor of rat cerebral cortical membranes [AID37459, Type: Literature]
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42
[SID103190535]
IC50 1.766DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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43
[SID26754418]
Potency 1.9953qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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44
[SID103190535]
Ki 2Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101 [AID36103, Type: Literature]
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45
[SID103190535]
Ki 2.4Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes [AID32954, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
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46
[SID103190535]
Ki 2.4Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes [AID32954, Type: Literature]Alpha-1D adrenergic receptor [gi:1168244]
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47
[SID103190535]
Ki 2.4Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes [AID32954, Type: Literature]Alpha-1A adrenergic receptor [gi:1168247]
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48
[SID103190535]
IC50 2.449DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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49
[SID90341589]
Potency 2.5119HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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50
[SID26754420]
Potency 2.6679qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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