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Isoproterenol (CID 5807) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(40)
 
 
Inactive(1065)
 
 
Inconclusive(106)
 
 
Unspecified(27)
 
 
Top Targets:
7TM GPCR Srsx(31)
 
 
 
NR LBD PPAR(26)
 
 
 
7TM GPCR Srx(24)
 
 
 
NR LBD TR(20)
 
 
NR LBD ER(19)
 
 
 
BioAssay Types:
Confirmatory(682)
 
 
 
 
 
Screening(390)
 
 
 
 
Summary(50)
 
 
 
 
Literature(32)
 
 
 
 
BioActivity Types:
Potency(635)
 
 
 
 
 
IC50(31)
 
 
 
EC50(9)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 862    Data Row: 1238   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50085961]
Potency 0.0082qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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2
[SID103676191]
EC50 0.12882Agonist activity at recombinant human beta2 adrenoceptor expressed in DU145 cells assessed as increase in cAMP accumulation [AID637886, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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3
[SID50085961]
Potency 0.1836qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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4
[SID103676191]
EC50 0.24Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting [AID637823, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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5
[SID17388957]
Potency 0.3981qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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6
[SID103676191]
Ki 0.501Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells [AID637822, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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7
[SID56320928]
EC50_MICROM 0.822Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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8
[SID56320927]
EC50_MICROM 0.828Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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9
[SID50085961]
Potency 7.0795qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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10
[SID103676191]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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11
[SID50085961]
Potency 11.2202qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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12
[SID26747558]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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13
[SID50106483]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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14
[SID50106527]
Potency 15.8489qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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15
[SID144210628]
AhR Potency (uM) 61.1306qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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16
[SID144210628]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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17
[SID144210628]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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18
[SID50085961]
IC50 100High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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19
[SID8149393]
Cellular toxicity caused by inducible expressing of N-terminal huntingtin with expanded ployglutamine repeat (Htt-N63-148Q) in PC12 cells (ROSShtt) [AID1590, Type: other]
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20
[SID8149393]
Screen for compounds that suppress mutant SOD1-mediated cell death (mSODtox) [AID1601, Type: other]
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21
[SID50085961]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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22
[SID56320927]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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23
[SID56320928]
HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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24
[SID103676191]
Adrenergic receptor beta agonist [AID742484, Type: other]Beta-3 adrenergic receptor [gi:461604]
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25
[SID56463187]
HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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26
[SID56320927]
HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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27
[SID56320927]
HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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28
[SID50085961]
HTS Assay for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Primary Screen for Potentiators [AID485347, Type: screening]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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29
[SID50085961]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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30
[SID50085961]
qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Enhancers [AID493056, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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31
[SID50085961]
Confirmatory screen for compounds that inhibit the Choline Transporter (CHT) [AID493221, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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32
[SID56320927]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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33
[SID56320927]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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34
[SID50085961]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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35
[SID50085961]
QFRET-based biochemical high throughput confirmation assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2170, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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36
[SID103676191]
Adrenergic receptor beta agonist [AID742484, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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37
[SID26611789]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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38
[SID17405272]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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39
[SID50085961]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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40
[SID103676191]
Adrenergic receptor beta agonist [AID742484, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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41
[SID50106527]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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42
[SID50106483]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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43
[SID103676191]
Reversible inhibition of human AChE using acetylthiocholine as substrate assessed as apparent dissociation constant for enzyme-inhibitor complex [AID698397, Type: Literature]Acetylcholinesterase [gi:113037]
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44
[SID103676191]
Reversible inhibition of human BChE usual homozygous variant using propionylthiocholine as substrate assessed as apparent dissociation constant for enzyme-inhibitor complex [AID698401, Type: Literature]Cholinesterase [gi:116353]
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45
[SID50085961]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID103676191]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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47
[SID103676191]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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48
[SID17388957]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
49
[SID26752241]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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50
[SID103676191]
Binding affinity to human BChE D70G mutant atypical homozygous variant relative to terbutaline [AID698392, Type: Literature]
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