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CHEMBL397570 (CID 579429) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(7)
 
 
Inconclusive(1)
 
 
Unspecified(458)
 
 
Top Targets:
PKc(42)
 
 
PKc like(42)
 
 
STKc AGC(16)
 
 
PTKc Abl(16)
 
 
PTKc Src like(11)
 
 
 
BioAssay Types:
Confirmatory(5)
 
 
 
 
Literature(4)
 
 
 
 
BioActivity Types:
Potency(6)
 
 
 
 
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 469    Data Row: 469   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124349947]
Potency 0.919qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID103534541]
IC50 3.16228Inhibition of human truncated JNK3 [AID298743, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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3
[SID134352847]
A screen for small compounds that change glucocorticoid sensitivity in NFkB suppression [AID624486, Type: other]
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4
[SID103534541]
IC50 10Inhibition of human recombinant full length JNK1alpha1 [AID298742, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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5
[SID103534541]
IC50 15.8489Inhibition of mitogen-activated protein kinase p38alpha [AID298744, Type: Literature]
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6
[SID103534541]
GSK_PKIS: PIP5K1 (Caliper assay) % inhibition at 5 uM [UNC Frye lab] [AID651545, Type: other]
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7
[SID103534541]
GSK_PKIS: CDK3/cyclinE mean inhibition at 0.1 uM [Nanosyn] [AID651168, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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8
[SID103534541]
GSK_PKIS: CDK3/cyclinE mean inhibition at 1 uM [Nanosyn] [AID651169, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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9
[SID103534541]
GSK_PKIS: MAPK3 mean inhibition at 0.1 uM [Nanosyn] [AID651198, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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10
[SID103534541]
GSK_PKIS: MAPK3 mean inhibition at 1 uM [Nanosyn] [AID651199, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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11
[SID103534541]
GSK_PKIS: CDK6/cyclinD3 mean inhibition at 0.1 uM [Nanosyn] [AID651174, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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12
[SID103534541]
GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn] [AID651175, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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13
[SID103534541]
GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] [AID651350, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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14
[SID103534541]
GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] [AID651351, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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15
[SID103534541]
GSK_PKIS: EGFR mean inhibition at 0.1 uM [Nanosyn] [AID651402, Type: other]Epidermal growth factor receptor [gi:2811086]
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16
[SID103534541]
GSK_PKIS: EGFR mean inhibition at 1 uM [Nanosyn] [AID651403, Type: other]Epidermal growth factor receptor [gi:2811086]
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17
[SID103534541]
GSK_PKIS: EGFR (L858R mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651404, Type: other]Epidermal growth factor receptor [gi:2811086]
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18
[SID103534541]
GSK_PKIS: EGFR (L858R mutant) mean inhibition at 1 uM [Nanosyn] [AID651405, Type: other]Epidermal growth factor receptor [gi:2811086]
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19
[SID103534541]
GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651406, Type: other]Epidermal growth factor receptor [gi:2811086]
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20
[SID103534541]
GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 1 uM [Nanosyn] [AID651407, Type: other]Epidermal growth factor receptor [gi:2811086]
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21
[SID103534541]
GSK_PKIS: EGFR (T790M mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651408, Type: other]Epidermal growth factor receptor [gi:2811086]
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22
[SID103534541]
GSK_PKIS: EGFR (T790M mutant) mean inhibition at 1 uM [Nanosyn] [AID651409, Type: other]Epidermal growth factor receptor [gi:2811086]
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23
[SID103534541]
GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651410, Type: other]Epidermal growth factor receptor [gi:2811086]
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24
[SID103534541]
GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 1 uM [Nanosyn] [AID651411, Type: other]Epidermal growth factor receptor [gi:2811086]
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25
[SID103534541]
GSK_PKIS: PHKG1 mean inhibition at 0.1 uM [Nanosyn] [AID651132, Type: other]Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [gi:2833281]
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26
[SID103534541]
GSK_PKIS: PHKG1 mean inhibition at 1 uM [Nanosyn] [AID651133, Type: other]Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [gi:2833281]
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27
[SID103534541]
GSK_PKIS: P38gamma mean inhibition at 0.1 uM [Nanosyn] [AID651208, Type: other]Mitogen-activated protein kinase 12 [gi:2851522]
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28
[SID103534541]
GSK_PKIS: P38gamma mean inhibition at 1 uM [Nanosyn] [AID651209, Type: other]Mitogen-activated protein kinase 12 [gi:2851522]
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29
[SID103534541]
GSK_PKIS: CK1-g2 mean inhibition at 0.1 uM [Nanosyn] [AID651158, Type: other]Casein kinase I isoform gamma-2 [gi:3024060]
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30
[SID103534541]
GSK_PKIS: CK1-g2 mean inhibition at 1 uM [Nanosyn] [AID651159, Type: other]Casein kinase I isoform gamma-2 [gi:3024060]
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31
[SID103534541]
GSK_PKIS: PYK2 mean inhibition at 0.1 uM [Nanosyn] [AID651302, Type: other]Protein-tyrosine kinase 2-beta [gi:3183003]
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32
[SID103534541]
GSK_PKIS: PYK2 mean inhibition at 1 uM [Nanosyn] [AID651303, Type: other]Protein-tyrosine kinase 2-beta [gi:3183003]
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33
[SID103534541]
GSK_PKIS: PDK1 mean inhibition at 0.1 uM [Nanosyn] [AID651038, Type: other][Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [gi:3183117]
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34
[SID103534541]
GSK_PKIS: PDK1 mean inhibition at 1 uM [Nanosyn] [AID651039, Type: other][Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [gi:3183117]
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35
[SID103534541]
GSK_PKIS: DYRK1A mean inhibition at 0.1 uM [Nanosyn] [AID651180, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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36
[SID103534541]
GSK_PKIS: DYRK1A mean inhibition at 1 uM [Nanosyn] [AID651181, Type: other]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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37
[SID103534541]
GSK_PKIS: ERBB4 mean inhibition at 0.1 uM [Nanosyn] [AID651426, Type: other]Receptor tyrosine-protein kinase erbB-4 [gi:3913590]
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38
[SID103534541]
GSK_PKIS: ERBB4 mean inhibition at 1 uM [Nanosyn] [AID651427, Type: other]Receptor tyrosine-protein kinase erbB-4 [gi:3913590]
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39
[SID103534541]
GSK_PKIS: CDK5/p35 mean inhibition at 0.1 uM [Nanosyn] [AID651172, Type: other]Cyclin-dependent kinase 5 [gi:4033704]
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40
[SID103534541]
GSK_PKIS: CDK5/p35 mean inhibition at 1 uM [Nanosyn] [AID651173, Type: other]Cyclin-dependent kinase 5 [gi:4033704]
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41
[SID103534541]
GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn] [AID651164, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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42
[SID103534541]
GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn] [AID651165, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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43
[SID103534541]
GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn] [AID651166, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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44
[SID103534541]
GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn] [AID651167, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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45
[SID103534541]
GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn] [AID651424, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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46
[SID103534541]
GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn] [AID651425, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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47
[SID103534541]
GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn] [AID651196, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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48
[SID103534541]
GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn] [AID651197, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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49
[SID103534541]
GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn] [AID651432, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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50
[SID103534541]
GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn] [AID651433, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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