SB-347804 (CID 579429) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(2)
 
 
Inconclusive(1)
 
 
Unspecified(456)
 
 
Top Targets:
PKc(48)
 
 
PKc like(40)
 
 
STKc AGC(28)
 
 
PTKc Abl(16)
 
 
PTKc EGFR(10)
 
 
BioAssay Types:
Literature(3)
 
 
 
Confirmatory(3)
 
 
 
 
BioActivity Types:
IC50(3)
 
 
 
Potency(3)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 461    Data Row: 461   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124349947]
Potency 0.919qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID103534541]
IC50 3.16228Inhibition of human truncated JNK3 [AID298743, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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3
[SID103534541]
IC50 3.16228Inhibition of human truncated JNK3 [AID298743, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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4
[SID103534541]
IC50 10Inhibition of human recombinant full length JNK1alpha1 [AID298742, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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5
[SID103534541]
IC50 10Inhibition of human recombinant full length JNK1alpha1 [AID298742, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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6
[SID103534541]
IC50 15.8489Inhibition of mitogen-activated protein kinase p38alpha [AID298744, Type: Literature]
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7
[SID103534541]
 GSK_PKIS: PIP5K1 (Caliper assay) % inhibition at 5 uM [UNC Frye lab] [AID651545, Type: other]
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8
[SID103534541]
 GSK_PKIS: P38beta mean inhibition at 0.1 uM [Nanosyn] [AID651204, Type: other]Mitogen-activated protein kinase 11 [gi:134047835]
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9
[SID103534541]
 GSK_PKIS: P38beta mean inhibition at 0.1 uM [Nanosyn] [AID651204, Type: other]Mitogen-activated protein kinase 11 [gi:134047835]
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10
[SID103534541]
 GSK_PKIS: P38beta mean inhibition at 1 uM [Nanosyn] [AID651205, Type: other]Mitogen-activated protein kinase 11 [gi:134047835]
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11
[SID103534541]
 GSK_PKIS: P38beta mean inhibition at 1 uM [Nanosyn] [AID651205, Type: other]Mitogen-activated protein kinase 11 [gi:134047835]
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12
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn] [AID651194, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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13
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn] [AID651194, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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14
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn] [AID651194, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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15
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn] [AID651195, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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16
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn] [AID651195, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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17
[SID103534541]
 GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn] [AID651195, Type: other]Mitogen-activated protein kinase 9 [gi:85700366]
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18
[SID103534541]
 GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] [AID651206, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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19
[SID103534541]
 GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] [AID651206, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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20
[SID103534541]
 GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] [AID651207, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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21
[SID103534541]
 GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] [AID651207, Type: other]Mitogen-activated protein kinase 13 [gi:6685642]
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22
[SID103534541]
 GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] [AID651350, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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23
[SID103534541]
 GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] [AID651350, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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24
[SID103534541]
 GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] [AID651351, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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25
[SID103534541]
 GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] [AID651351, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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26
[SID103534541]
 GSK_PKIS: PRKX mean inhibition at 0.1 uM [Nanosyn] [AID651066, Type: other]cAMP-dependent protein kinase catalytic subunit PRKX [gi:1709648]
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27
[SID103534541]
 GSK_PKIS: PRKX mean inhibition at 0.1 uM [Nanosyn] [AID651066, Type: other]cAMP-dependent protein kinase catalytic subunit PRKX [gi:1709648]
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28
[SID103534541]
 GSK_PKIS: PRKX mean inhibition at 1 uM [Nanosyn] [AID651067, Type: other]cAMP-dependent protein kinase catalytic subunit PRKX [gi:1709648]
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29
[SID103534541]
 GSK_PKIS: PRKX mean inhibition at 1 uM [Nanosyn] [AID651067, Type: other]cAMP-dependent protein kinase catalytic subunit PRKX [gi:1709648]
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30
[SID103534541]
 GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] [AID651394, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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31
[SID103534541]
 GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] [AID651394, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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32
[SID103534541]
 GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] [AID651395, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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33
[SID103534541]
 GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] [AID651395, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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34
[SID103534541]
 GSK_PKIS: MAP4K2 mean inhibition at 0.1 uM [Nanosyn] [AID651346, Type: other]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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35
[SID103534541]
 GSK_PKIS: MAP4K2 mean inhibition at 0.1 uM [Nanosyn] [AID651346, Type: other]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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36
[SID103534541]
 GSK_PKIS: MAP4K2 mean inhibition at 1 uM [Nanosyn] [AID651347, Type: other]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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37
[SID103534541]
 GSK_PKIS: MAP4K2 mean inhibition at 1 uM [Nanosyn] [AID651347, Type: other]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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38
[SID103534541]
 GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn] [AID651458, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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39
[SID103534541]
 GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn] [AID651458, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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40
[SID103534541]
 GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn] [AID651459, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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41
[SID103534541]
 GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn] [AID651459, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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42
[SID103534541]
 GSK_PKIS: RET mean inhibition at 0.1 uM [Nanosyn] [AID651304, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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43
[SID103534541]
 GSK_PKIS: RET mean inhibition at 0.1 uM [Nanosyn] [AID651304, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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44
[SID103534541]
 GSK_PKIS: RET mean inhibition at 1 uM [Nanosyn] [AID651305, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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45
[SID103534541]
 GSK_PKIS: RET mean inhibition at 1 uM [Nanosyn] [AID651305, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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46
[SID103534541]
 GSK_PKIS: RET (V804L mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651306, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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47
[SID103534541]
 GSK_PKIS: RET (V804L mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651306, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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48
[SID103534541]
 GSK_PKIS: RET (V804L mutant) mean inhibition at 1 uM [Nanosyn] [AID651307, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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49
[SID103534541]
 GSK_PKIS: RET (V804L mutant) mean inhibition at 1 uM [Nanosyn] [AID651307, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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50
[SID103534541]
 GSK_PKIS: RET (Y791F mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651308, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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