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MLS000043052 (CID 5771498) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(843)
 
 
Inconclusive(13)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(21)
 
 
 
alkPPc(14)
 
 
Tryp SPc(14)
 
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(593)
 
 
 
 
 
Confirmatory(258)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(48)
 
 
EC50(13)
 
 
 
AC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 814    Data Row: 881   Total Pages: 18   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134959047]
AC50_uM 2.96GSK3beta Measured in Biochemical System Using Plate Reader - 2046-01_Inhibitor_Dose_DryPowder_Activity [AID623998, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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2
[SID4251658]
EC50_uM 3.932Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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3
[SID4251658]
Potency 25.1189qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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4
[SID4251658]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID4251658]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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6
[SID4251658]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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7
[SID4251658]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID4251658]
Cell-Free Homogeneous Primary HTS to Identify Inhibitors of GSK3beta Activity [AID2097, Type: screening]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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9
[SID4251658]
Allosteric Modulators of D1 Receptors: Dose-dependent Assay [AID858, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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10
[SID4251658]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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11
[SID4251658]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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12
[SID4251658]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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13
[SID4251658]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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14
[SID4251658]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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15
[SID4251658]
HTS Assay for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Primary Screen for Potentiators [AID485347, Type: screening]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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16
[SID4251658]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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17
[SID4251658]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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18
[SID4251658]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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19
[SID4251658]
Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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20
[SID4251658]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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21
[SID4251658]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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22
[SID4251658]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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23
[SID4251658]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID4251658]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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25
[SID4251658]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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26
[SID4251658]
Potency 0.0029Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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27
[SID4251658]
Potency 5.6234qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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28
[SID4251658]
Potency 63.0957qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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29
[SID4251658]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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30
[SID4251658]
EC50_uM 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo Reagents [AID434947, Type: confirmatory]
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31
[SID4251658]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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32
[SID4251658]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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33
[SID4251658]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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34
[SID4251658]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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35
[SID4251658]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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36
[SID4251658]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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37
[SID4251658]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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38
[SID4251658]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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39
[SID4251658]
qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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40
[SID4251658]
Primary HTS Assay for Inhibitors of Bacterial Quorum Sensing [AID527, Type: screening]
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41
[SID4251658]
Antimicrobial HTS Assay for E. coli BW25113 (wild type) [AID552, Type: screening]
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42
[SID4251658]
Human SK-BR-3 Breast Tumor Cell Growth Inhibition In a 24- Hour Assay (Pilot Screen) [AID572, Type: screening]
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43
[SID4251658]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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44
[SID4251658]
Human Endothelial Cell Proliferation Assay [AID575, Type: screening]
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45
[SID4251658]
Human H69AR Lung Tumor Cell Growth Inhibition Assay [AID580, Type: screening]
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46
[SID4251658]
VCAM-1 Imaging Assay in Pooled HUVECs: Augmentation of TNFa induced VCAM-1 cell surface expression. [AID457, Type: screening]
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47
[SID4251658]
Isolation of Inhibitors of Her-Kinase Expression - 66K library screen [AID645, Type: screening]
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48
[SID4251658]
Allosteric Modulators of D1 Receptors: Secondary Assay 1 [AID646, Type: other]
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49
[SID4251658]
Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance [AID602, Type: screening]
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50
[SID4251658]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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