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F0473-0413 (CID 5771440) - Compound BioActivity Data
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BioActivity Outcomes:
Active(36)
 
 
Inactive(805)
 
 
Inconclusive(26)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(568)
 
 
 
 
Confirmatory(262)
 
 
 
 
 
Literature(6)
 
 
BioActivity Types:
Potency(168)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 800    Data Row: 869   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4249140]
Potency 2.8184qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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2
[SID4249140]
Potency 3.1623qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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3
[SID4249140]
IC50_Mean 3.93Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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4
[SID4249140]
IC50_Mean 3.93Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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5
[SID4249140]
Potency 5.0119qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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6
[SID4249140]
Potency 7.5686qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID4249140]
Potency 15.1014qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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8
[SID4249140]
Potency 17.7828qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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9
[SID4249140]
Auto-fluorescence of compounds effecting screening of VLA-4 Integrin [AID576, Type: other]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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10
[SID4249140]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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11
[SID4249140]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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12
[SID4249140]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
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13
[SID4249140]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin beta-2 precursor [Homo sapiens] [gi:89191865]
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14
[SID4249140]
Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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15
[SID4249140]
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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16
[SID4249140]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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17
[SID4249140]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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18
[SID4249140]
Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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19
[SID4249140]
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M1 [gi:113121]
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20
[SID4249140]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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21
[SID4249140]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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22
[SID4249140]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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23
[SID4249140]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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24
[SID4249140]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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25
[SID4249140]
Dose-response cell-based assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID692, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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26
[SID4249140]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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27
[SID4249140]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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28
[SID4249140]
Single concentration confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based assay [AID624504, Type: screening]
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29
[SID4249140]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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30
[SID4249140]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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31
[SID4249140]
Screen for Chemicals that Extend Yeast Lifespan [AID775, Type: screening]
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32
[SID4249140]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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33
[SID4249140]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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34
[SID4249140]
Antimicrobial Assay for E. coli BW25113 ∆tolC::kan - Dose Response [AID617, Type: confirmatory]
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35
[SID4249140]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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36
[SID4249140]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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37
[SID4249140]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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38
[SID4249140]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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39
[SID4249140]
Potency 0.3548qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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40
[SID4249140]
Potency 1.122qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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41
[SID4249140]
Potency 2.0749qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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42
[SID4249140]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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43
[SID4249140]
Potency 3.9811qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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44
[SID4249140]
Potency 7.9433qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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45
[SID4249140]
IC50_Mean 20Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651639, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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46
[SID4249140]
IC50_Mean 20Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651639, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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47
[SID4249140]
EC50_Mean 53Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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48
[SID4249140]
EC50_Mean 53Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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49
[SID4249140]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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50
[SID4249140]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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