Reserpine (CID 5770) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(210)
 
 
Inactive(661)
 
 
Inconclusive(282)
 
 
Unspecified(369)
 
 
Top Targets:
ABC MTABC3 MD..(34)
 
 
 
7TM GPCR Srx(31)
 
 
 
 
MFS(19)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
NR LBD TR(10)
 
 
 
BioAssay Types:
Confirmatory(480)
 
 
 
 
 
Literature(342)
 
 
 
 
 
Screening(284)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(379)
 
 
 
 
 
IC50(167)
 
 
 
 
 
Ki(10)
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1175    Data Row: 1522   Total Pages: 31   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204244]
Ki 0.001Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts [AID321546, Type: Literature]Synaptic vesicular amine transporter [gi:2499124]
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2
[SID103204244]
Ki 0.1Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model [AID150616, Type: Literature]
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3
[SID50105550]
Potency 0.2818qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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4
[SID103204244]
IC50 0.31623Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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5
[SID103204244]
IC50 0.774DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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6
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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7
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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8
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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9
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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10
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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11
[SID103204244]
IC50 0.79433Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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12
[SID103204244]
IC50 0.821DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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13
[SID50105550]
Potency 0.8913qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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14
[SID50105550]
Potency 0.9285Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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15
[SID50105550]
Potency 1.2589qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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16
[SID103204244]
IC50 1.25893Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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17
[SID50105550]
Potency 1.4716Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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18
[SID56463068]
Potency 1.4716Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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19
[SID103204244]
IC50 1.6Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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20
[SID56463068]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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21
[SID50105550]
Potency 1.7783qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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22
[SID103204244]
IC50 1.99526Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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23
[SID103204244]
IC50 1.99526Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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24
[SID50105550]
Potency 1.9953qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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25
[SID103204244]
IC50 2.05DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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26
[SID50105550]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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27
[SID103204244]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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28
[SID103204244]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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29
[SID50105550]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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30
[SID103204244]
IC50 3.23594Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay [AID364884, Type: Literature]
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31
[SID50105551]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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32
[SID50105552]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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33
[SID50105553]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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34
[SID50105550]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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35
[SID17389743]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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36
[SID26752948]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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37
[SID103204244]
IC50 3.707DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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38
[SID103204244]
IC50 4.152DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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39
[SID103204244]
IC50 4.152DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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40
[SID103204244]
IC50 4.152DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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41
[SID103204244]
IC50 4.152DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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42
[SID26752948]
Potency 4.7755Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
43
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
44
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
45
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
46
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
47
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
48
[SID103204244]
IC50 7Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux dose response curve based fluorometric assay [AID612622, Type: Literature]Quinolone resistance protein Nor [gi:60392839]
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49
[SID90341213]
Potency 7.3048qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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50
[SID26752948]
Potency 7.5686Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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