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Reserpine (CID 5770) - Compound BioActivity Data
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BioActivity Outcomes:
Active(265)
 
 
Inactive(854)
 
 
Inconclusive(406)
 
 
Unspecified(386)
 
 
Top Targets:
7TM GPCR Srx(43)
 
 
 
 
 
ABC MTABC3 MD..(35)
 
 
 
NR LBD PPAR(34)
 
 
 
7TM GPCR Srsx(33)
 
 
 
NR LBD ER(28)
 
 
 
 
 
BioAssay Types:
Confirmatory(721)
 
 
 
 
 
Literature(363)
 
 
 
 
 
Screening(334)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(671)
 
 
 
 
 
IC50(172)
 
 
 
 
 
Ki(10)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1334    Data Row: 1911   Total Pages: 39   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204244]
Ki 0.001Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts [AID321546, Type: Literature]Synaptic vesicular amine transporter [gi:2499124]
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2
[SID103204244]
Ki 0.1Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model [AID150616, Type: Literature]
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3
[SID50105550]
Potency 0.2818qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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4
[SID103204244]
IC50 0.31623Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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5
[SID103204244]
IC50 0.774DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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6
[SID50105550]
Potency 0.7943qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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7
[SID103204244]
IC50 0.79433Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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8
[SID103204244]
IC50 0.821DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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9
[SID144204658]
Potency-Replicate_1 0.8477qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID50105550]
Potency 0.8913qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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11
[SID50105550]
Potency 0.9285Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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12
[SID144204658]
Ratio Potency (uM) 1.19739qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID50105550]
Potency 1.2589qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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14
[SID103204244]
IC50 1.25893Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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15
[SID50105550]
Potency 1.4716Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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16
[SID56463068]
Potency 1.4716Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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17
[SID103204244]
IC50 1.6Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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18
[SID56463068]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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19
[SID50105550]
Potency 1.7783qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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20
[SID103204244]
IC50 1.99526Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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21
[SID103204244]
IC50 1.99526Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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22
[SID50105550]
Potency 1.9953qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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23
[SID103204244]
IC50 2.05DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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24
[SID50105550]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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25
[SID103204244]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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26
[SID103204244]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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27
[SID50105550]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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28
[SID103204244]
IC50 3.23594Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay [AID364884, Type: Literature]
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29
[SID26752948]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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30
[SID50105550]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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31
[SID50105551]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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32
[SID50105552]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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33
[SID50105553]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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34
[SID17389743]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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35
[SID103204244]
IC50 3.707DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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36
[SID103204244]
IC50 4.152DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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37
[SID144210855]
Potency-Replicate_1 4.4889qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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38
[SID26752948]
Potency 4.7755Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
39
[SID17389743]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
View
40
[SID103204244]
IC50 7Inhibition of NorA in Staphylococcus aureus 1199B assessed as inhibition of ethidium bromide efflux dose response curve based fluorometric assay [AID612622, Type: Literature]Quinolone resistance protein NorA [gi:60392839]
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41
[SID90341213]
Potency 7.3048qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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42
[SID26752948]
Potency 7.5686Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
43
[SID50105550]
Potency 7.9433Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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44
[SID50105550]
Potency 7.9433qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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45
[SID103204244]
IC50 8Inhibition of NorA efflux pump in Staphylococcus aureus K3092 assessed as inhibition of EtBr efflux [AID372221, Type: Literature]
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46
[SID103204244]
IC50 8.2Inhibition of norA-mediated ethidium bromide efflux in methicillin-resistant Staphylococcus aureus SA-1199B by spectrofluorometric analysis [AID695899, Type: Literature]Quinolone resistance protein NorA [gi:60392839]
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47
[SID17389743]
Potency 8.9125qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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48
[SID144210855]
Ratio Potency (uM) 9.67104qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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49
[SID56463068]
Potency 10qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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50
[SID90341213]
Potency 10qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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