BAS 00665668 (CID 5759184) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(70)
 
 
Inactive(531)
 
 
Inconclusive(22)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
ABCC CFTR1(9)
 
 
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(418)
 
 
 
 
Confirmatory(195)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(123)
 
 
 
 
 
IC50(49)
 
 
 
 
 
AC50(10)
 
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 622    Data Row: 628   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24805492]
IC50 0.607Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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2
[SID24805492]
IC50 0.607Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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3
[SID24805492]
IC50 0.607Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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4
[SID24805492]
Potency 1qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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5
[SID24805492]
IC50 1.25Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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6
[SID24805492]
IC50 1.25Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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7
[SID24805492]
IC50 1.25Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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8
[SID24805492]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24805492]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID24805492]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID24805492]
Potency 2.2387qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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12
[SID24805492]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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13
[SID24805492]
IC50 2.89Dose Response selectivity of uHTS chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation in Jurkat cells using a luminescence assay [AID489006, Type: confirmatory]
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14
[SID24805492]
IC50 3.13Dose response confirmation of uHTS of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489023, Type: confirmatory]
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15
[SID24805492]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID24805492]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID24805492]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID24805492]
AC50 3.27Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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19
[SID24805492]
Potency 4.1078qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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20
[SID24805492]
Potency 4.4668qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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21
[SID24805492]
Potency 4.4668qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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22
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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23
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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24
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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25
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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26
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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27
[SID24805492]
AC50 6.632MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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28
[SID24805492]
AC50 7.23Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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29
[SID24805492]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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30
[SID24805492]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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31
[SID24805492]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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32
[SID24805492]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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33
[SID24805492]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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34
[SID24805492]
IC50 8.391High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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35
[SID24805492]
IC50 8.773Concentration-Response Confirmation Assays for HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules [AID463136, Type: confirmatory]
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36
[SID24805492]
Potency 10.3183qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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37
[SID24805492]
Potency 14.1254qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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38
[SID24805492]
AC50 16.79Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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39
[SID24805492]
Potency 17.7828qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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40
[SID24805492]
Potency 17.7828qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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41
[SID24805492]
Potency 19.9526qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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42
[SID24805492]
AC50 21.859MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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43
[SID24805492]
AC50 21.859MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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44
[SID24805492]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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45
[SID24805492]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules: Confirmation Assay [AID463116, Type: screening]
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46
[SID24805492]
 Single concentration confirmation of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID449746, Type: screening]
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47
[SID24805492]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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48
[SID24805492]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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49
[SID24805492]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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50
[SID24805492]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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