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Estradiol (CID 5757) - Compound BioActivity Data
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BioActivity Outcomes:
Active(435)
 
 
Inactive(1430)
 
 
Inconclusive(321)
 
 
Unspecified(881)
 
 
Top Targets:
NR LBD ER(591)
 
 
 
 
 
7TM GPCR Srx(47)
 
 
 
7TM GPCR Srsx(39)
 
 
 
NR LBD PPAR(29)
 
 
 
 
NR LBD AR(27)
 
 
 
 
 
BioAssay Types:
Literature(1183)
 
 
 
 
 
Confirmatory(840)
 
 
 
 
 
Screening(562)
 
 
 
 
Summary(64)
 
 
 
 
BioActivity Types:
Potency(784)
 
 
 
 
 
IC50(311)
 
 
 
 
 
EC50(115)
 
 
 
 
Kd(35)
 
 
Ki(22)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2153    Data Row: 3067   Total Pages: 62   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189263]
EC50 1e-06Estrogenic activity in human ERalpha expressing MCF7:WS8 cells assessed as stimulation of cell proliferation after 7 days [AID473402, Type: Literature]
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2
[SID103189263]
EC50 1.52e-06Growth response in cultures of MCF-7 (human breast cancer cell line) cells [AID103554, Type: Literature]
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3
[SID103189263]
Kd 3e-06Binding affinity for Estrogen receptor alpha [AID238122, Type: Literature]
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4
[SID103189263]
EC50 3.7e-06Estrogenic activity in human MCF7 cells assessed as cell proliferation after 6 days by WST8 assay [AID348700, Type: Literature]
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5
[SID103189263]
EC50 4e-06Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707063, Type: Literature]Estrogen receptor [gi:544257]
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6
[SID103189263]
ED50 4.56e-06Functional ERalpha receptor activity in transcriptional activation assay in MCF-7 cells [AID70194, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID103189263]
EC50 6.4e-06Antiproliferative activity against estrogen-deficient human MCF7 cells after 72 hrs by MTT assay [AID658958, Type: Literature]
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8
[SID103189263]
EC50 7e-06Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alpha [AID70188, Type: Literature]Estrogen receptor [gi:544257]
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9
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor [gi:544257]
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10
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103189263]
EC50 1e-05Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporter [AID257302, Type: Literature]Estrogen receptor [gi:544257]
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12
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor beta [gi:6166154]
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14
[SID103189263]
EC50 1e-05Activation of human ERbeta expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707072, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID103189263]
EC50 1e-05Effective concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103375, Type: Literature]
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16
[SID103189263]
EC50 1e-05Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells [AID91597, Type: Literature]
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17
[SID103189263]
EC50 1.8e-05Transcriptional potency (EC50) at Human estrogen receptor alpha [AID223390, Type: Literature]
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18
[SID103189263]
EC50 1.9e-05Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30 mins at RT [AID254648, Type: Literature]Estrogen receptor [gi:544257]
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19
[SID103189263]
EC50 1.96e-05Estrogenic activity at estrogen receptor in human MCF7:D5L cells co-expressing ERE assessed as induction of luciferase gene expression after 16 hrs by microplate reader [AID658955, Type: Literature]
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20
[SID103189263]
EC50 2e-05Effective dose for [3H]- estradiol against proliferation of MCF-7 cells [AID102435, Type: Literature]
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21
[SID103189263]
EC50 2e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
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22
[SID103189263]
EC50 2.46e-05Estrogenic activity at estrogen receptor in human Ishikawa cells assessed as induction of alkaline phosphatase expression after 72 hrs by microplate reader [AID658961, Type: Literature]
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23
[SID103189263]
EC50 3.01e-05Induction of pS2 Gene expression in human MCF-7 cells [AID103551, Type: Literature]Estrogen receptor [gi:544257]
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24
[SID103189263]
EC50 3.01e-05Induction of pS2 Gene expression in human MCF-7 cells [AID103551, Type: Literature]Estrogen receptor beta [gi:6166154]
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25
[SID103189263]
EC50 3.6e-05Transcriptional activation of ERbeta receptor expressed in CHO-K1 cells after 24 hrs by luciferase reporter gene assay [AID677857, Type: Literature]
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26
[SID103189263]
EC50 3.9e-05Transcriptional potency (EC50) at Human estrogen receptor Beta [AID70021, Type: Literature]
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27
[SID103189263]
EC50 4.6e-05Agonist activity at ERalpha expressed in HEK cells co-expressing beta-lactamase after 18 hrs by beta-lactamase reporter gene assay [AID622837, Type: Literature]
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28
[SID103189263]
EC50 4.7e-05Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolism of p-nitrophenol phosphatase after 72 hrs [AID333509, Type: Literature]Estrogen receptor [gi:544257]
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29
[SID103189263]
EC50 5e-05Transcriptional activation of ERalpha receptor expressed in CHO-K1 cells after 24 hrs by luciferase reporter gene assay [AID677856, Type: Literature]
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30
[SID103189263]
ED50 6e-05Effective dose in immature rat uterotrophic growth assay [AID246833, Type: Literature]Estrogen receptor [gi:119600]
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31
[SID103189263]
ED50 6e-05Effective dose in immature rat uterotrophic growth assay [AID246833, Type: Literature]Estrogen receptor beta [gi:6166156]
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32
[SID103189263]
EC50 6.17e-05Transactivation of human ERbeta expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay [AID478663, Type: Literature]Estrogen receptor beta [gi:6166154]
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33
[SID103189263]
EC50 6.46e-05Transactivation of human ERalpha expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay [AID478662, Type: Literature]Estrogen receptor [gi:544257]
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34
[SID103189263]
EC50 7e-05Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alpha [AID70190, Type: Literature]Estrogen receptor [gi:544257]
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35
[SID103189263]
EC50 7e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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36
[SID103189263]
EC50 8e-05Concentration required to activate luciferase expression in MCF-7-2a cells [AID103077, Type: Literature]
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37
[SID103189263]
EC50 8e-05Effective concentration against human ER positive MCF-7 breast cancer cell line evaluated by luciferase assay [AID255650, Type: Literature]
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38
[SID103189263]
EC50 9e-05Agonist activity at human full-length ERalpha receptor expressed in human HEC1 cells co-expressing (ERE)2-pS2-luc gene assessed as transcriptional activation after 24 hrs by luciferase reporter gene assay [AID601684, Type: Literature]Estrogen receptor [gi:544257]
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39
[SID103189263]
EC50 9.8e-05Transcriptional activation of estrogen receptor beta in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30 mins at RT [AID254647, Type: Literature]Estrogen receptor beta [gi:6166154]
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40
[SID103189263]
EC50 9.96e-05Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells [AID103552, Type: Literature]Estrogen receptor [gi:544257]
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41
[SID103189263]
EC50 9.96e-05Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells [AID103552, Type: Literature]Estrogen receptor beta [gi:6166154]
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42
[SID103189263]
EC50 0.0001Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control [AID707065, Type: Literature]Estrogen receptor [gi:544257]
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43
[SID103189263]
EC50 0.0001Agonist activity in transcriptional activation assay in SH-SY5Y neuroblastoma cells expressing Estrogen receptor beta [AID70506, Type: Literature]Estrogen receptor beta [gi:6166154]
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44
[SID103189263]
EC50 0.0001Agonist activity at ERalpha expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter gene assay [AID436349, Type: Literature]
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45
[SID103189263]
IC50 0.0001Inhibition of chemoattractant-induced cell migration of human SK-BR-3 cells after 48 hrs by transwell migration assay [AID503166, Type: Literature]
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46
[SID103189263]
Ki 0.000113Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMF [AID68905, Type: Literature]Estrogen receptor beta [gi:6166154]
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47
[SID103189263]
Ki 0.000113Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMF [AID68905, Type: Literature]Estrogen receptor [gi:544257]
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48
[SID103189263]
Ki 0.00012Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
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49
[SID103189263]
Ki 0.00012Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor beta [gi:6166154]
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50
[SID103189263]
EC50 0.000123Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay [AID644928, Type: Literature]Estrogen receptor [gi:544257]
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