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Estradiol (CID 5757) - Compound BioActivity Data
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BioActivity Outcomes:
Active(447)
 
 
Inactive(1458)
 
 
Inconclusive(315)
 
 
Unspecified(1182)
 
 
Top Targets:
NR LBD ER(597)
 
 
 
 
 
7TM GPCR Srx(47)
 
 
 
7TM GPCR Srsx(39)
 
 
 
NR LBD PPAR(29)
 
 
 
 
NR LBD AR(27)
 
 
 
 
 
BioAssay Types:
Literature(1236)
 
 
 
 
 
Confirmatory(958)
 
 
 
 
 
Screening(565)
 
 
 
 
Summary(64)
 
 
 
 
BioActivity Types:
Potency(788)
 
 
 
 
 
IC50(315)
 
 
 
 
 
EC50(118)
 
 
 
 
Kd(42)
 
 
Ki(25)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2466    Data Row: 3402   Total Pages: 171   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189263]
EC50 1e-06Estrogenic activity in human ERalpha expressing MCF7:WS8 cells assessed as stimulation of cell proliferation after 7 days [AID473402, Type: Literature]
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2
[SID103189263]
EC50 1.52e-06Growth response in cultures of MCF-7 (human breast cancer cell line) cells [AID103554, Type: Literature]
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3
[SID103189263]
Kd 3e-06Binding affinity for Estrogen receptor alpha [AID238122, Type: Literature]
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4
[SID103189263]
EC50 3.7e-06Estrogenic activity in human MCF7 cells assessed as cell proliferation after 6 days by WST8 assay [AID348700, Type: Literature]
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5
[SID103189263]
EC50 4e-06Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707063, Type: Literature]Estrogen receptor [gi:544257]
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6
[SID103189263]
ED50 4.56e-06Functional ERalpha receptor activity in transcriptional activation assay in MCF-7 cells [AID70194, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID103189263]
EC50 6.4e-06Antiproliferative activity against estrogen-deficient human MCF7 cells after 72 hrs by MTT assay [AID658958, Type: Literature]
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8
[SID103189263]
EC50 7e-06Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alpha [AID70188, Type: Literature]Estrogen receptor [gi:544257]
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9
[SID103189263]
EC50 1e-05Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporter [AID257302, Type: Literature]Estrogen receptor [gi:544257]
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10
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor [gi:544257]
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12
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor beta [gi:6166154]
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14
[SID103189263]
EC50 1e-05Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells [AID91597, Type: Literature]
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15
[SID103189263]
EC50 1e-05Effective concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103375, Type: Literature]
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16
[SID103189263]
EC50 1e-05Activation of human ERbeta expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707072, Type: Literature]Estrogen receptor beta [gi:6166154]
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17
[SID103189263]
EC50 1.8e-05Transcriptional potency (EC50) at Human estrogen receptor alpha [AID223390, Type: Literature]
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18
[SID103189263]
EC50 1.9e-05Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30 mins at RT [AID254648, Type: Literature]Estrogen receptor [gi:544257]
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19
[SID103189263]
EC50 1.96e-05Estrogenic activity at estrogen receptor in human MCF7:D5L cells co-expressing ERE assessed as induction of luciferase gene expression after 16 hrs by microplate reader [AID658955, Type: Literature]
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20
[SID103189263]
EC50 2e-05Effective dose for [3H]- estradiol against proliferation of MCF-7 cells [AID102435, Type: Literature]
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