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Estriol (CID 5756) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(888)
 
 
Inconclusive(29)
 
 
Unspecified(379)
 
 
Top Targets:
7tm 4(77)
 
 
 
NR LBD ER(28)
 
 
 
 
 
NR LBD PPAR(22)
 
 
p450(18)
 
 
 
 
GT1 Gtf like(15)
 
 
BioAssay Types:
Screening(506)
 
 
 
 
Confirmatory(445)
 
 
 
 
 
Literature(70)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(311)
 
 
 
 
 
IC50(156)
 
 
 
 
 
EC50(9)
 
 
 
Kd(2)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1160    Data Row: 1322   Total Pages: 67   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103469357]
EC50 0.000126Agonist activity at ER-beta (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay [AID1077858, Type: confirmatory]Estrogen receptor beta [gi:6166154]
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2
[SID144205873]
Potency-Replicate_1 0.0007qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144211921]
Potency-Replicate_1 0.0015qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID103469357]
IC50 0.00169DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: confirmatory]Estrogen receptor [gi:544257]
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5
[SID103469357]
EC50 0.002Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay [AID1077859, Type: confirmatory]Estrogen receptor [gi:544257]
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6
[SID144211921]
Ratio Potency (uM) 0.00206539qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID144205873]
Potency-Replicate_1 0.0024qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID144205873]
Ratio Potency (uM) 0.00408854qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID103469357]
Kd 0.23442Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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10
[SID144211921]
Potency-Replicate_1 6.9167qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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11
[SID103469357]
IC50 8.635DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: confirmatory]Arachidonate 15-lipoxygenase [gi:126397]
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12
[SID103469357]
IC50 10.336DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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13
[SID144205873]
Potency-Replicate_1 11.9856qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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14
[SID144211921]
Ratio Potency (uM) 13.8006qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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15
[SID144205873]
Potency-Replicate_1 18.9959qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144205873]
Ratio Potency (uM) 20.1215qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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17
[SID144211921]
Potency-Replicate_1 38.8952qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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18
[SID103469357]
IC50 39.345DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: confirmatory]Glucocorticoid receptor [gi:121069]
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19
[SID144211921]
AR Potency (uM) 54.4827qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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20
[SID144211921]
TR Potency (uM) 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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