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Prednisolone (CID 5755) - Compound BioActivity Data
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BioActivity Outcomes:
Active(163)
 
 
Inactive(803)
 
 
Inconclusive(64)
 
 
Unspecified(690)
 
 
Top Targets:
NR LBD GR(134)
 
 
 
 
7tm 4(70)
 
 
 
NR LBD AR(26)
 
 
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD PPAR(24)
 
 
 
BioAssay Types:
Literature(577)
 
 
 
 
 
Confirmatory(471)
 
 
 
 
 
Screening(384)
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(367)
 
 
 
 
 
IC50(199)
 
 
 
 
 
EC50(65)
 
 
 
 
 
Ki(35)
 
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1485    Data Row: 1720   Total Pages: 86   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189031]
EC50 2e-06Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assay [AID626803, Type: Literature]Mineralocorticoid receptor [gi:126885]
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2
[SID103189031]
Ki 0.00029Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells [AID1071639, Type: Literature]Mineralocorticoid receptor [gi:126885]
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3
[SID103189031]
EC50 0.0004Effective concentration of compound for transcriptional activation of collagenase in Human cell native protein assay [AID90421, Type: Literature]
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4
[SID103189031]
Ki 0.00114Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cells [AID1071638, Type: Literature]Glucocorticoid receptor [gi:121069]
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5
[SID103189031]
Ki 0.0015Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assay [AID351941, Type: Literature]Glucocorticoid receptor [gi:121069]
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6
[SID103189031]
Ki 0.0015Displacement of GS-red from GRapha by fluorescence polarization assay [AID604795, Type: Literature]
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7
[SID103189031]
Ki 0.0015Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assay [AID626799, Type: Literature]
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8
[SID103189031]
EC50 0.002Effective concentration of compound for transcriptional activation of PGE-2 in Human cell native protein assay [AID90305, Type: Literature]
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9
[SID103189031]
EC50 0.002Agonist activity at mineralocorticoid receptor in human A549 cells [AID604856, Type: Literature]Mineralocorticoid receptor [gi:126885]
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10
[SID103189031]
IC50 0.0021Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptor [AID47369, Type: Literature]Glucocorticoid receptor [gi:121069]
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11
[SID103189031]
EC50 0.0021Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor [AID81558, Type: Literature]Glucocorticoid receptor [gi:121069]
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12
[SID103189031]
IC50 0.0021Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to Dexamethasone [AID202433, Type: Literature]Glucocorticoid receptor [gi:121069]
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13
[SID103189031]
Ki 0.0024Binding affinity for glucocorticoid receptor [AID74232, Type: Literature]Glucocorticoid receptor [gi:121069]
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14
[SID103189031]
Ki 0.0024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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15
[SID103189031]
Ki 0.0024Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexamethasone [AID74225, Type: Literature]
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16
[SID103189031]
Ki 0.0024Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cells [AID74226, Type: Literature]
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17
[SID103189031]
EC50 0.0026Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc). [AID86563, Type: Literature]
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18
[SID103189031]
EC50 0.003Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-beta challenge measured after 24 hrs by transrepression assay [AID480396, Type: Literature]Glucocorticoid receptor [gi:121069]
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19
[SID103189031]
EC50 0.0033The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE). [AID47372, Type: Literature]
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20
[SID103189031]
EC50 0.0034Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity [AID296307, Type: Literature]Glucocorticoid receptor [gi:121069]
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