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Prednisolone (CID 5755) - Compound BioActivity Data
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BioActivity Outcomes:
Active(156)
 
 
Inactive(782)
 
 
Inconclusive(76)
 
 
Unspecified(494)
 
 
Top Targets:
NR LBD GR(130)
 
 
 
 
7TM GPCR Srx(38)
 
 
 
7TM GPCR Srsx(32)
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(25)
 
 
 
 
 
BioAssay Types:
Literature(502)
 
 
 
 
 
Screening(383)
 
 
 
Confirmatory(354)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(366)
 
 
 
 
 
IC50(197)
 
 
 
 
 
EC50(65)
 
 
 
 
 
Ki(31)
 
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1280    Data Row: 1508   Total Pages: 31   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189031]
EC50 2e-06Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assay [AID626803, Type: Literature]Mineralocorticoid receptor [gi:126885]
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2
[SID103189031]
EC50 0.0004Effective concentration of compound for transcriptional activation of collagenase in Human cell native protein assay [AID90421, Type: Literature]
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3
[SID103189031]
Ki 0.0015Displacement of GS-red from GRapha by fluorescence polarization assay [AID604795, Type: Literature]
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4
[SID103189031]
Ki 0.0015Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assay [AID626799, Type: Literature]
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5
[SID103189031]
Ki 0.0015Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assay [AID351941, Type: Literature]Glucocorticoid receptor [gi:121069]
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6
[SID103189031]
EC50 0.002Agonist activity at mineralocorticoid receptor in human A549 cells [AID604856, Type: Literature]Mineralocorticoid receptor [gi:126885]
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7
[SID103189031]
EC50 0.002Effective concentration of compound for transcriptional activation of PGE-2 in Human cell native protein assay [AID90305, Type: Literature]
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8
[SID103189031]
IC50 0.0021Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to Dexamethasone [AID202433, Type: Literature]Glucocorticoid receptor [gi:121069]
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9
[SID103189031]
IC50 0.0021Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptor [AID47369, Type: Literature]Glucocorticoid receptor [gi:121069]
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10
[SID103189031]
EC50 0.0021Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor [AID81558, Type: Literature]Glucocorticoid receptor [gi:121069]
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11
[SID103189031]
Ki 0.0024Binding affinity for glucocorticoid receptor [AID74232, Type: Literature]Glucocorticoid receptor [gi:121069]
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12
[SID103189031]
Ki 0.0024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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13
[SID103189031]
Ki 0.0024Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexamethasone [AID74225, Type: Literature]
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14
[SID103189031]
Ki 0.0024Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cells [AID74226, Type: Literature]
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15
[SID103189031]
EC50 0.0026Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc). [AID86563, Type: Literature]
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16
[SID103189031]
EC50 0.003Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-beta challenge measured after 24 hrs by transrepression assay [AID480396, Type: Literature]Glucocorticoid receptor [gi:121069]
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17
[SID103189031]
EC50 0.0033The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE). [AID47372, Type: Literature]
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18
[SID103189031]
EC50 0.0034Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells [AID240099, Type: Literature]Glucocorticoid receptor [gi:121073]
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19
[SID103189031]
EC50 0.0034Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity [AID296307, Type: Literature]Glucocorticoid receptor [gi:121069]
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20
[SID103189031]
EC50 0.0036Effective concentration of compound for transcriptional activation of IL-6 in Human cell native protein assay [AID90304, Type: Literature]
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21
[SID103189031]
IC50 0.0038Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potency [AID91902, Type: Literature]Glucocorticoid receptor [gi:121069]
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22
[SID103189031]
ED50 0.004Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay [AID330359, Type: Literature]Glucocorticoid receptor [gi:121069]
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23
[SID103189031]
IC50 0.0041Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay [AID552806, Type: Literature]Glucocorticoid receptor [gi:121069]
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24
[SID103189031]
IC50 0.0041Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-selectin repression by luciferase reporter gene assay [AID589653, Type: Literature]Glucocorticoid receptor [gi:121069]
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25
[SID103189031]
IC50 0.0041Activity at GR assessed as repression of TNFalpha and IL 1-beta induced E-selectin response [AID299615, Type: Literature]
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26
[SID103189031]
IC50 0.0041Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression [AID331521, Type: Literature]
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27
[SID103189031]
IC50 0.0041Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay [AID578377, Type: Literature]
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28
[SID103189031]
IC50 0.0041Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay relative to Dexamethasone [AID579571, Type: Literature]
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29
[SID103189031]
EC50 0.0045GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells [AID240069, Type: Literature]Glucocorticoid receptor [gi:121069]
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30
[SID103189031]
EC50 0.0045Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 [AID296301, Type: Literature]Glucocorticoid receptor [gi:121069]
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31
[SID103189031]
EC50 0.0045Ability to induce human IL-6 assay in A549 lung carcinoma cell line. [AID8455, Type: Literature]Glucocorticoid receptor [gi:121069]
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32
[SID103189031]
EC50 0.0053Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assay [AID589660, Type: Literature]Glucocorticoid receptor [gi:121069]
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33
[SID103189031]
EC50 0.0053Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter gene assay [AID552720, Type: Literature]Glucocorticoid receptor [gi:121069]
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34
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from GR [AID579568, Type: Literature]
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35
[SID103189031]
EC50 0.0053Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity relative to Dexamethasone [AID579569, Type: Literature]
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36
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirus [AID552717, Type: Literature]
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37
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from GR [AID578373, Type: Literature]
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38
[SID103189031]
EC50 0.0053Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity [AID578374, Type: Literature]
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39
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from glucocorticoid receptor expressed in baculovirus [AID589652, Type: Literature]
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40
[SID103189031]
EC50 0.0053Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assay [AID331517, Type: Literature]
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41
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from glucocorticoid receptor [AID299616, Type: Literature]
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42
[SID103189031]
Ki 0.0053Displacement of radiolabeled Dexamethasone from glucocorticoid receptor [AID331514, Type: Literature]
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43
[SID103189031]
EC50 0.0053Agonist activity at GR by GRE activation assay [AID299612, Type: Literature]
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44
[SID103189031]
EC50 0.0057Ability to induce mouse macrophage IL-6 assay in peritoneal exudate cells harvested by gavage from C57BI/6 mice. [AID127633, Type: Literature]
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45
[SID103189031]
EC50 0.0057GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice [AID240161, Type: Literature]Glucocorticoid receptor [gi:121073]
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46
[SID103189031]
EC50 0.0057Activity at human glucocorticoid receptor in C57BI/6 mouse peritonial exudate cells assessed as repression of mouse IL6 [AID296305, Type: Literature]Glucocorticoid receptor [gi:121069]
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47
[SID103189031]
IC50 0.0059Inhibition of IL4 and LPS-induced IgE production in BALB/c mouse spleen B cell after 6 days by ELISA [AID394967, Type: Literature]
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48
[SID103189031]
IC50 0.0066Inhibition of IL1-stimulated IL6 production in HFF cells [AID274993, Type: Literature]
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49
[SID103189031]
IC50 0.0066Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA [AID515517, Type: Literature]Glucocorticoid receptor [gi:121069]
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50
[SID103189031]
IC50 0.007Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assay [AID480395, Type: Literature]Glucocorticoid receptor [gi:121069]
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