Bookmark and Share
Hydrocortisone (CID 5754) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(58)
 
 
Inactive(1660)
 
 
Inconclusive(79)
 
 
Unspecified(386)
 
 
Top Targets:
7TM GPCR Srx(62)
 
 
 
 
7TM GPCR Srsx(51)
 
 
 
NR LBD PPAR(27)
 
 
 
NR LBD ER(22)
 
 
 
 
 
Tryp SPc(19)
 
 
 
BioAssay Types:
Screening(915)
 
 
 
 
Confirmatory(702)
 
 
 
 
 
Literature(286)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(593)
 
 
 
 
 
IC50(195)
 
 
 
 
EC50(11)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1541    Data Row: 2183   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234238]
IC50 0.01Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction [AID589396, Type: Literature]
View
2
[SID104234238]
IC50 0.0150 percent inhibitory concentration of compound to inhibit nitric oxide production induced by IFN-gamma in mouse macrophages [AID224263, Type: Literature]
View
3
[SID104234238]
IC50 0.01Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224269, Type: Literature]
View
4
[SID104234238]
IC50 0.01Inhibitory activity against nitric oxide production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224272, Type: Literature]
View
5
[SID104234238]
IC50 0.01Inhibitory activity against production of nitric oxide induced by interferon-gamma in mouse macrophages [AID132692, Type: Literature]
View
6
[SID144208013]
Ratio Potency (uM) 0.0102642qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
7
[SID26751520]
Potency 0.0141qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
8
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
View
9
[SID104234238]
IC50 0.015Compound was measured for its inhibitory activity on IFN-gamma-induced nitric oxide production in mouse macrophage [AID132492, Type: other]
View
10
[SID144204434]
Potency-Replicate_1 0.0213qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
11
[SID144204434]
Ratio Potency (uM) 0.0230141qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
12
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
View
13
[SID144208013]
Potency-Replicate_1 0.0278qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
14
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
15
[SID144208013]
Ratio Potency (uM) 0.0393239qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
16
[SID104234238]
IC50 0.061Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction [AID589397, Type: Literature]
View
17
[SID144208013]
Potency-Replicate_1 0.0693qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
18
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
19
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory] [geneid:4780]
View
20
[SID144204434]
Ratio Potency (uM) 0.0785827qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
21
[SID26751520]
Potency 0.0794qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
22
[SID144204434]
Potency-Replicate_1 0.1188qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
23
[SID56422453]
Potency 0.1636Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
24
[SID855803]
Potency 0.1995qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
View
25
[SID56422453]
Potency 0.206Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
26
[SID85148352]
Potency 0.2909Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
27
[SID104234238]
Kd 0.63096Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
View
28
[SID144204434]
Potency-Replicate_1 3.7578qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
29
[SID104234238]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View
30
[SID855803]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
31
[SID855803]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
32
[SID104234238]
IC50 40.64Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay [AID527190, Type: Literature]
View
33
[SID104234238]
IC50 40.64Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotmetry [AID617128, Type: Literature]
View
34
[SID104234238]
IC50 40.64Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction [AID716419, Type: Literature]
View
35
[SID75748]
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line [AID113, Type: confirmatory]
View
36
[SID104234238]
Tested for inhibitory activity against B lymphocyte proliferation induced by LPS at 10e-7 M; suppressed the proliferation [AID38027, Type: Literature]
View
37
[SID104234238]
Inhibition of survival rate of SD mouse osteoclasts at 10 umol/L after 48 hrs by TRAP assay [AID305525, Type: Literature]
View
38
[SID104234238]
Inhibition of survival rate of SD mouse osteoclasts at 100 nmol/L to 10 umol/L after 48 hrs by TRAP assay [AID305526, Type: Literature]
View
39
[SID104234238]
Increase in survival rate of SD mouse osteoclasts at 10 pmol/L to 100 nmol/L after 48 hrs by TRAP assay [AID305527, Type: Literature]
View
40
[SID104234238]
Tested for inhibitory activity against T lymphocyte proliferation induced by Con A at 10e-7 M; showed potent suppressive effect [AID209947, Type: Literature]
View
41
[SID104234238]
Tested for inhibitory activity against T lymphocyte proliferation induced by PHA at 10e-7 M; showed potent suppressive effect [AID209948, Type: Literature]
View
42
[SID104234238]
Effect on modulation in uptake of [3H]progesterone in Escherichia coli AG102 with marR1 mutation [AID283561, Type: Literature]
View
43
[SID104234238]
Antiinflammatory activity against croton oil-induced ear inflammation in BALB/c mouse at 200 ug/ear after 6 to 24 hrs [AID354573, Type: Literature]
View
44
[SID104234238]
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
View
45
[SID104234238]
Antiinflammatory effect in CD1 mouse ear dermatitis model assessed as reduction in vascular changes at 0.04 umol administered topically per cm'2 of ear measured after 6 hrs post dermatitis induction relative to control [AID688472, Type: Literature]
View
46
[SID104234238]
Antiinflammatory effect in CD1 mouse ear dermatitis model assessed as reduction in cellular changes at 0.04 umol administered topically per cm'2 of ear measured after 6 hrs post dermatitis induction relative to control [AID688473, Type: Literature]
View
47
[SID104234238]
Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL-10 production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595632, Type: Literature]
View
48
[SID104234238]
Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL-6 production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595633, Type: Literature]
View
49
[SID104234238]
Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL1-beta production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595634, Type: Literature]
View
50
[SID104234238]
Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of TNFalpha production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595635, Type: Literature]
View