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Hydrocortisone (CID 5754) - Compound BioActivity Data
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BioActivity Outcomes:
Active(66)
 
 
Inactive(1694)
 
 
Inconclusive(68)
 
 
Unspecified(577)
 
 
Top Targets:
7tm 4(114)
 
 
 
 
NR LBD PPAR(27)
 
 
 
NR LBD ER(22)
 
 
 
 
 
NR LBD GR(21)
 
 
 
 
 
Tryp SPc(19)
 
 
 
BioAssay Types:
Screening(919)
 
 
 
 
Confirmatory(823)
 
 
 
 
 
Literature(356)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(598)
 
 
 
 
 
IC50(196)
 
 
 
 
EC50(11)
 
 
Kd(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1739    Data Row: 2405   Total Pages: 121   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID53813055]
Kd 0.005Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Struture Of Corticosteroid-Binding Globulin In Complex With Cortisol [gi:158431126]
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2
[SID53813055]
Kd 0.005Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Struture Of Corticosteroid-Binding Globulin In Complex With Cortisol [gi:158431126]
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3
[SID104234238]
IC50 0.01Inhibitory activity against production of nitric oxide induced by interferon-gamma in mouse macrophages [AID132692, Type: Literature]
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4
[SID104234238]
IC50 0.0150 percent inhibitory concentration of compound to inhibit nitric oxide production induced by IFN-gamma in mouse macrophages [AID224263, Type: Literature]
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5
[SID104234238]
IC50 0.01Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224269, Type: Literature]
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6
[SID104234238]
IC50 0.01Inhibitory activity against nitric oxide production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224272, Type: Literature]
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7
[SID104234238]
IC50 0.01Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction [AID589396, Type: Literature]
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8
[SID144208013]
Ratio Potency (uM) 0.0102642qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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9
[SID26751520]
Potency 0.0141qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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10
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein, partial [Homo sapiens] [gi:21620132]
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11
[SID104234238]
IC50 0.015Compound was measured for its inhibitory activity on IFN-gamma-induced nitric oxide production in mouse macrophage [AID132492, Type: confirmatory]
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12
[SID144204434]
Potency-Replicate_1 0.0213qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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13
[SID144204434]
Ratio Potency (uM) 0.0230141qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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14
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: confirmatory]Glucocorticoid receptor [gi:121069]
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15
[SID144208013]
Potency-Replicate_1 0.0278qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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17
[SID144208013]
Ratio Potency (uM) 0.0393239qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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18
[SID104234238]
IC50 0.061Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction [AID589397, Type: Literature]
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19
[SID144204434]
Potency-Replicate_1 0.0674qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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20
[SID144208013]
Potency-Replicate_1 0.0693qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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