Hydrocortisone (CID 5754) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(39)
 
 
Inactive(1426)
 
 
Inconclusive(37)
 
 
Unspecified(374)
 
 
Top Targets:
7TM GPCR Srx(45)
 
 
 
7TM GPCR Srsx(27)
 
 
 
alkPPc(18)
 
 
Tryp SPc(16)
 
 
 
ABC MTABC3 MD..(13)
 
 
 
 
BioAssay Types:
Screening(798)
 
 
 
 
Confirmatory(527)
 
 
 
 
 
Literature(328)
 
 
 
 
 
BioActivity Types:
Potency(387)
 
 
 
 
 
IC50(187)
 
 
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1387    Data Row: 1876   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234238]
IC50 0.01Inhibitory activity against production of nitric oxide induced by interferon-gamma in mouse macrophages [AID132692, Type: Literature]
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2
[SID104234238]
IC50 0.0150 percent inhibitory concentration of compound to inhibit nitric oxide production induced by IFN-gamma in mouse macrophages [AID224263, Type: Literature]
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3
[SID104234238]
IC50 0.01Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224269, Type: Literature]
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4
[SID104234238]
IC50 0.01Inhibitory activity against nitric oxide production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224272, Type: Literature]
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5
[SID104234238]
IC50 0.01Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction [AID589396, Type: Literature]
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6
[SID26751520]
Potency 0.0141qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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7
[SID26751520]
Potency 0.0141qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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9
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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10
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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11
[SID855803]
Potency 0.0141qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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12
[SID104234238]
IC50 0.015Compound was measured for its inhibitory activity on IFN-gamma-induced nitric oxide production in mouse macrophage [AID132492, Type: other]
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13
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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14
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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15
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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16
[SID104234238]
IC50 0.026DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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17
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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18
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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19
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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20
[SID85148352]
Potency 0.0291Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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21
[SID104234238]
IC50 0.061Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction [AID589397, Type: Literature]
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22
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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23
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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24
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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25
[SID90341326]
Potency 0.0731Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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26
[SID26751520]
Potency 0.0794qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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27
[SID26751520]
Potency 0.0794qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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28
[SID26751520]
Potency 0.0794qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
29
[SID26751520]
Potency 0.0794qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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30
[SID56422453]
Potency 0.1636Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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31
[SID56422453]
Potency 0.1636Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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32
[SID56422453]
Potency 0.1636Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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33
[SID56422453]
Potency 0.1636Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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34
[SID855803]
Potency 0.1995qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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35
[SID855803]
Potency 0.1995qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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36
[SID855803]
Potency 0.1995qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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37
[SID104234238]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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38
[SID855803]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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39
[SID104234238]
IC50 40.64Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay [AID527190, Type: Literature]
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40
[SID104234238]
IC50 40.64Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotmetry [AID617128, Type: Literature]
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41
[SID104234238]
 Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL-10 production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595632, Type: Literature]
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42
[SID104234238]
 Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL-6 production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595633, Type: Literature]
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43
[SID104234238]
 Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of IL1-beta production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595634, Type: Literature]
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44
[SID104234238]
 Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of TNFalpha production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by ELISA relative to control [AID595635, Type: Literature]
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45
[SID104234238]
 Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production at 0.5 to 50 ug/ml pretreated for 4 hrs followed by challenge with 1 ug/mL LPS for 48 hrs by Griess reaction method relative to control [AID595637, Type: Literature]
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46
[SID104234238]
 Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
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47
[SID104234238]
 Antiinflammatory activity against croton oil-induced ear inflammation in BALB/c mouse at 200 ug/ear after 6 to 24 hrs [AID354573, Type: Literature]
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48
[SID104234238]
 Tested for inhibitory activity against T lymphocyte proliferation induced by Con A at 10e-7 M; showed potent suppressive effect [AID209947, Type: Literature]
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49
[SID104234238]
 Tested for inhibitory activity against T lymphocyte proliferation induced by PHA at 10e-7 M; showed potent suppressive effect [AID209948, Type: Literature]
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50
[SID104234238]
 Effect on modulation in uptake of [3H]progesterone in Escherichia coli AG102 with marR1 mutation [AID283561, Type: Literature]
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