Corticosterone (CID 5753) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(1078)
 
 
Inconclusive(87)
 
 
Unspecified(110)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
NR LBD PPAR(16)
 
 
 
MFS(15)
 
 
alkPPc(14)
 
 
Tryp SPc(12)
 
 
BioAssay Types:
Screening(559)
 
 
 
 
Confirmatory(481)
 
 
 
 
 
Literature(158)
 
 
 
 
 
BioActivity Types:
Potency(377)
 
 
 
 
 
IC50(53)
 
 
 
 
EC50(11)
 
 
Ki(11)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1083    Data Row: 1287   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26751495]
Potency 0.2239qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID26751495]
Potency 0.2239qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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3
[SID17389502]
Potency 0.3162qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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4
[SID17389502]
Potency 0.3162qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID56423132]
Potency 0.4109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID56423132]
Potency 0.4109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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7
[SID56423132]
Potency 0.4109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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8
[SID56423132]
Potency 0.4109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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9
[SID90341091]
Potency 6.5131Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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10
[SID90341091]
Potency 6.5131Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
11
[SID90341091]
Potency 6.5131Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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12
[SID90341091]
Potency 6.5131Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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13
[SID103333099]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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14
[SID103333099]
IC50 10Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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15
[SID103333099]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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16
[SID103333099]
IC50 23.4423Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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17
[SID103333099]
Ki 35.6Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239347, Type: Literature]
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18
[SID855741]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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19
[SID855741]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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20
[SID855741]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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21
[SID855741]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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22
[SID855741]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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23
[SID56423132]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_Activity [AID504775, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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24
[SID103333099]
IC50 0.29TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT3-expressing HEK293 cells [AID682144, Type: other]Solute carrier family 22 member 3 [gi:24212063]
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25
[SID103333099]
Ki 0.39TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells [AID679639, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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26
[SID103333099]
Ki 0.42TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells [AID679641, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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27
[SID103333099]
Ki 0.46TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells [AID679637, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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28
[SID103333099]
Ki 0.605TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells [AID679636, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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29
[SID103333099]
IC50 4TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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30
[SID103333099]
IC50 4.2TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells [AID681591, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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31
[SID103333099]
IC50 4.9TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells [AID678784, Type: other]Solute carrier family 22 member 3 [gi:24212062]
View
32
[SID103333099]
Ki 5.3TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells [AID681147, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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33
[SID103333099]
Ki 7.02TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells [AID681146, Type: other]Solute carrier family 22 member 1 [gi:313104181]
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34
[SID103333099]
Ki 10TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes [AID681157, Type: other]Solute carrier family 22 member 1 [gi:81872095]
View
35
[SID103333099]
IC50 10.7TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytes [AID679293, Type: other]Solute carrier family 22 member 2 [gi:81872789]
View
36
[SID103333099]
IC50 21.7TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT1-expressing HEK293 cells [AID681560, Type: other]Solute carrier family 22 member 1 [gi:313104181]
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37
[SID103333099]
IC50 34.2TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT2-expressing HEK293 cells [AID681561, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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38
[SID103333099]
Ki 72TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells [AID681376, Type: other]Solute carrier family 22 member 1 [gi:81872095]
View
39
[SID103333099]
Ki 100Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand [AID239597, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:17374795]
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40
[SID103333099]
Ki 100Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239296, Type: Literature]
View
41
[SID103333099]
IC50 151TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: other]Solute carrier family 22 member 1 [gi:81872095]
View
42
[SID103333099]
IC50 163.7TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes [AID679317, Type: other]Solute carrier family 22 member 1 [gi:81872095]
View
43
[SID103333099]
 TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Corticosterone: 100 uM) in OCT1-expressing HRPE cells [AID679211, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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44
[SID103333099]
 Relative binding affinity against glucocorticoid receptor in rat liver cystosol extract [AID74246, Type: Literature]Glucocorticoid receptor [gi:1169883]
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45
[SID103333099]
 TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.010? uM, Corticosterone: 500 uM) in OCTN2-expressing HEK293 cells [AID681677, Type: other]Solute carrier family 22 member 5 [gi:8928257]
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46
[SID103333099]
 TP_TRANSPORTER: increase in brain concentration in mdr1a/1b(-/-) mouse [AID682053, Type: other]Multidrug resistance protein 1B [gi:126927]
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47
[SID103333099]
 TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, Corticosterone: 5 uM) in Xenopus laevis oocytes [AID681227, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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48
[SID103333099]
 Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy [AID386623, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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49
[SID103333099]
 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
View
50
[SID56423132]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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