AG-690/40137176 (CID 5751386) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(42)
 
 
Inactive(520)
 
 
Inconclusive(27)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
alkPPc(16)
 
 
Bcl-2 like(11)
 
 
Peptidase C48(7)
 
 
 
G-alpha(6)
 
 
 
BioAssay Types:
Screening(342)
 
 
 
 
 
Confirmatory(230)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(17)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 592    Data Row: 592   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID844552]
Potency 0.4256qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID844552]
Potency 0.6561qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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3
[SID844552]
Potency 1.2589qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID844552]
EC50 2.45Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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5
[SID844552]
Potency 3.9811qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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6
[SID844552]
Potency 4.4668qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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7
[SID844552]
Potency 6.5104qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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8
[SID844552]
Potency 10qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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9
[SID844552]
Potency 10qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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10
[SID844552]
Potency 10qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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11
[SID844552]
Potency 10qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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12
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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13
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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14
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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15
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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16
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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17
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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18
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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19
[SID844552]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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20
[SID844552]
Potency 11.2202qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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21
[SID844552]
Potency 14.1254qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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22
[SID844552]
Potency 14.1254qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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23
[SID844552]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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24
[SID844552]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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25
[SID844552]
Potency 15.8489qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]
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26
[SID844552]
Potency 15.8489qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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27
[SID844552]
IC50 35.79High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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28
[SID844552]
CC50 40A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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29
[SID844552]
IC50 63.84A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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30
[SID844552]
 Pyruvate Kinase [AID361, Type: confirmatory]pyruvate kinase [Geobacillus stearothermophilus] [gi:285623]
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31
[SID844552]
 Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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32
[SID844552]
 Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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33
[SID844552]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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34
[SID844552]
 Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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35
[SID844552]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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36
[SID844552]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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37
[SID844552]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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38
[SID844552]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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39
[SID844552]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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40
[SID844552]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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41
[SID844552]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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42
[SID844552]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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43
[SID844552]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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44
[SID844552]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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45
[SID844552]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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46
[SID844552]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
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47
[SID844552]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
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48
[SID844552]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
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49
[SID844552]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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50
[SID844552]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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