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Dexamethasone (CID 5743) - Compound BioActivity Data
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BioActivity Outcomes:
Active(306)
 
 
Inactive(1286)
 
 
Inconclusive(114)
 
 
Unspecified(528)
 
 
Top Targets:
NR LBD GR(86)
 
 
 
 
 
7TM GPCR Srx(54)
 
 
 
7TM GPCR Srsx(43)
 
 
 
ABC MTABC3 MD..(23)
 
 
p450(22)
 
 
 
 
 
BioAssay Types:
Screening(610)
 
 
 
 
Literature(606)
 
 
 
 
 
Confirmatory(587)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(483)
 
 
 
 
 
IC50(257)
 
 
 
 
 
EC50(53)
 
 
 
 
Ki(9)
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1575    Data Row: 2234   Total Pages: 45   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234229]
IC50 0.0001Inhibitory activity against production of nitric oxide induced by interferon-gamma in mouse macrophages [AID132692, Type: Literature]
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2
[SID104234229]
IC50 0.0001Inhibitory activity against production of nitric oxide induced by interferon gamma in mouse macrophages [AID140447, Type: Literature]
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3
[SID104234229]
IC50 0.0001Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224269, Type: Literature]
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4
[SID104234229]
ED50 0.0001Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay [AID330359, Type: Literature]Glucocorticoid receptor [gi:121069]
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5
[SID104234229]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature]Glucocorticoid receptor [gi:121069]
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6
[SID104234229]
IC50 0.0003Compound was evaluated for inhibitory activity against production of nitric oxide (NO) induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224258, Type: Literature]
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7
[SID104234229]
IC50 0.000316Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced MMP1 release after 18 hrs by MSD technology [AID483907, Type: Literature]
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8
[SID104234229]
EC50 0.00047Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs [AID724407, Type: Literature]
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9
[SID104234229]
EC50 0.0005Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay [AID300919, Type: Literature]
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10
[SID104234229]
IC50 0.000501Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced IL8 release after 18 hrs by MSD technology [AID483906, Type: Literature]
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11
[SID104234229]
IC50 0.000508Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517033, Type: Literature]Glucocorticoid receptor [gi:121069]
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12
[SID104234229]
IC50 0.00051Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs [AID626146, Type: Literature]Glucocorticoid receptor [gi:121069]
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13
[SID104234229]
IC50 0.00051Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA [AID515517, Type: Literature]Glucocorticoid receptor [gi:121069]
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14
[SID104234229]
IC50 0.00051Inhibition of IL1-stimulated IL6 production in HFF cells [AID274993, Type: Literature]
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15
[SID104234229]
IC50 0.000631Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced IL6 release after 18 hrs by MSD technology [AID483905, Type: Literature]
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16
[SID104234229]
EC50 0.00092Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs [AID724400, Type: Literature]
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17
[SID104234229]
EC50 0.001Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-5 production after 48 hrs [AID724393, Type: Literature]
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18
[SID104234229]
IC50 0.001Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID568216, Type: Literature]Glucocorticoid receptor [gi:121069]
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19
[SID104234229]
EC50 0.001Effective agonist concentration for transcriptional repression of IL-6 production in IL-1 stimulated human foreskin fibroblasts [AID255663, Type: Literature]Glucocorticoid receptor [gi:121069]
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20
[SID104234229]
IC50 0.001Agonist activity at GR in human A549 cells by NF-kappaB transrepression assay [AID429130, Type: Literature]Glucocorticoid receptor [gi:121069]
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21
[SID104234229]
EC50 0.001Activity at glucocorticoid receptor in human A549 cells assessed as effect on GRE promoter response by luciferase reporter assay [AID376629, Type: Literature]Glucocorticoid receptor [gi:121069]
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22
[SID104234229]
Ki 0.0011Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assay [AID351941, Type: Literature]Glucocorticoid receptor [gi:121069]
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23
[SID104234229]
EC50 0.0011Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luciferase reporter gene assay [AID351943, Type: Literature]Glucocorticoid receptor [gi:121069]
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24
[SID104234229]
EC50 0.0011Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay [AID604800, Type: Literature]Glucocorticoid receptor [gi:121069]
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25
[SID104234229]
Ki 0.0011Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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26
[SID104234229]
EC50 0.0011Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-selection promoter activation after 6 hrs by luciferase reporter gene based ELAM assay [AID443588, Type: Literature]
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27
[SID104234229]
Ki 0.0011Displacement of GS-red from GRapha by fluorescence polarization assay [AID604795, Type: Literature]
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28
[SID104234229]
IC50 0.00117Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells [AID267772, Type: Literature]Glucocorticoid receptor [gi:121069]
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29
[SID104234229]
IC50 0.00117Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay [AID304380, Type: Literature]Glucocorticoid receptor [gi:121069]
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30
[SID104234229]
Ki 0.0012Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assay [AID443585, Type: Literature]Glucocorticoid receptor [gi:121069]
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31
[SID104234229]
EC50 0.0012Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-13 production after 24 hrs [AID724398, Type: Literature]
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32
[SID104234229]
IC50 0.0014Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production [AID297839, Type: Literature]Glucocorticoid receptor [gi:121069]
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33
[SID104234229]
IC50 0.00158Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced collagenase promoter activity by luciferase reporter gene assay [AID516377, Type: Literature]Glucocorticoid receptor [gi:121069]
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34
[SID104234229]
EC50 0.0018Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 to 24 hrs by ELISA [AID626200, Type: Literature]Glucocorticoid receptor [gi:121069]
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35
[SID104234229]
EC50 0.0019Induction of aromatase activity in HFF cells assessed as production of beta estradiol by aromatase assay [AID274995, Type: Literature]
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36
[SID104234229]
EC50 0.0019Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced TNFalpha production after 48 hrs [AID724410, Type: Literature]
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37
[SID104234229]
EC50 0.002Antiinflammatory activity assessed as upregulation of aromatase in HFF cells by transactivation assay [AID300921, Type: Literature]
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38
[SID104234229]
Ki 0.0021Binding affinity to GR [AID297845, Type: Literature]
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39
[SID104234229]
EC50 0.0021Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced IL-1beta production after 48 hrs [AID724409, Type: Literature]
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40
[SID104234229]
IC50 0.0023Antinflammatory activity in rat polymorphonuclear leukocytes assessed as inhibition of LPS-stimulated nitric oxide production after 20 mins by Griess method [AID664573, Type: Literature]
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41
[SID104234229]
EC50 0.0024Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IP-10 production after 24 hrs [AID724399, Type: Literature]
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42
[SID104234229]
EC50 0.0025Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay [AID604797, Type: Literature]Glucocorticoid receptor [gi:121069]
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43
[SID104234229]
EC50 0.0025Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene activity [AID351942, Type: Literature]Glucocorticoid receptor [gi:121069]
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44
[SID104234229]
EC50 0.0025Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by luciferase reporter gene assay [AID443586, Type: Literature]
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45
[SID104234229]
IC50 0.00251Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-8 production [AID516375, Type: Literature]Glucocorticoid receptor [gi:121069]
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46
[SID104234229]
IC50 0.003Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant glucocorticoid receptor expressed in baculovirus infected insect cells by fluorescence polarization assay [AID626140, Type: Literature]Glucocorticoid receptor [gi:121069]
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47
[SID104234229]
IC50 0.003Displacement of TAMRA labeled Dexamethasone at human glucocorticoid receptor in insect cell [AID300916, Type: Literature]Glucocorticoid receptor [gi:121069]
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48
[SID104234229]
IC50 0.003Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assay [AID274990, Type: Literature]
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49
[SID104234229]
IC50 0.0034Inhibition of human GR [AID293006, Type: Literature]Glucocorticoid receptor [gi:121069]
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50
[SID104234229]
IC50 0.0034Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluorescence polarization microplate assay [AID515514, Type: Literature]
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