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BioActivity Data for Compound Dexamethasone (CID 5743)

BioActivity Outcomes:
Active(347)
 
 
Inactive(1340)
 
 
Inconclusive(109)
 
 
Unspecified(1323)
 
 
Top Targets:
NR LBD GR(110)
 
 
 
 
 
7tm 4(97)
 
 
 
ABC MTABC3 MD..(23)
 
 
p450(22)
 
 
 
 
 
NR LBD PPAR(18)
 
 
 
BioAssay Types:
Literature(751)
 
 
 
 
 
Confirmatory(728)
 
 
 
 
 
Screening(624)
 
 
 
 
Summary(26)
 
 
 
 
BioAssay Categories:
In vitro(189)
 
 
 
In vivo(759)
 
 
 
 
 
Biochemical(469)
 
 
 
 
 
Toxicity(814)
 
 
 
 
 
ADME(147)
 
 
 
 
 
Cell-based(582)
 
 
 
 
 
Organism-base..(19)
 
 
BioActivity Types:
Potency(492)
 
 
 
 
 
IC50(276)
 
 
 
 
 
EC50(61)
 
 
 
 
AC50(17)
 
 
Ki(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2444    Data Row: 3119   Total Pages: 156   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234229]
IC50 0.0001Inhibitory activity against production of nitric oxide induced by interferon-gamma in mouse macrophages [AID132692, Type: Literature]
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2
[SID104234229]
IC50 0.0001Inhibitory activity against production of nitric oxide induced by interferon gamma in mouse macrophages [AID140447, Type: Literature]
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3
[SID104234229]
IC50 0.0001Inhibition of nitric oxide (NO) production induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224269, Type: Literature]
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4
[SID104234229]
ED50 0.0001Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay [AID330359, Type: Literature]Glucocorticoid receptor [gi:121069]
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5
[SID104234229]
EC50 0.0002Agonist activity at human GR expressed in CV1 cells by GRE activation assay [AID297837, Type: Literature]Glucocorticoid receptor [gi:121069]
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6
[SID104234229]
IC50 0.0003Compound was evaluated for inhibitory activity against production of nitric oxide (NO) induced by interferon-gamma (IFN-gamma) in mouse macrophages [AID224258, Type: Literature]
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7
[SID104234229]
IC50 0.000316Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced MMP1 release after 18 hrs by MSD technology [AID483907, Type: Literature]
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8
[SID104234229]
Ki 0.00036Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells [AID1071639, Type: Literature]Mineralocorticoid receptor [gi:126885]
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9
[SID104234229]
EC50 0.00047Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs [AID724407, Type: Literature]
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10
[SID104234229]
IC50 0.0005Agonist activity at glucocorticoid receptor in human foreskin fibroblasts assessed as inhibition of IL-1-induced IL-6 production by trans-repression assay [AID1125610, Type: Literature]Glucocorticoid receptor [gi:121069]
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11
[SID104234229]
IC50 0.0005Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs [AID1058574, Type: Literature]Glucocorticoid receptor [gi:121069]
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12
[SID104234229]
EC50 0.0005Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay [AID300919, Type: Literature]
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13
[SID104234229]
IC50 0.000501Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced IL8 release after 18 hrs by MSD technology [AID483906, Type: Literature]
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14
[SID104234229]
IC50 0.000508Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by luciferase reporter gene assay [AID517033, Type: Literature]Glucocorticoid receptor [gi:121069]
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15
[SID104234229]
IC50 0.00051Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs [AID626146, Type: Literature]Glucocorticoid receptor [gi:121069]
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16
[SID104234229]
IC50 0.00051Inhibition of IL1-stimulated IL6 production in HFF cells [AID274993, Type: Literature]
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17
[SID104234229]
IC50 0.00051Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA [AID515517, Type: Literature]Glucocorticoid receptor [gi:121069]
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18
[SID104234229]
IC50 0.000631Antiinflammatory activity in human primary synovial fibroblasts assessed as inhibition of IL1-induced IL6 release after 18 hrs by MSD technology [AID483905, Type: Literature]
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19
[SID104234229]
Ki 0.00069Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cells [AID1071638, Type: Literature]Glucocorticoid receptor [gi:121069]
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20
[SID104234229]
EC50 0.00092Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs [AID724400, Type: Literature]
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