CHEMBL1950678 (CID 57401346) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(4)
 
 
Unspecified(1)
 
 
BioAssay Types:
Literature(7)
 
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136941525]
 Agonist activity at human P2Y purinoceptor 2 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration at 100 uM by spectrofluorimetry [AID647898, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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2
[SID136941525]
 Agonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration at 100 uM by spectrofluorimetry [AID647897, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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3
[SID136941525]
 Stability of the compound assessed as human e-NPP1-mediated hydrolysis at pH 8.5 after 20 mins by HPLC analysis [AID644880, Type: Literature]
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4
[SID136941525]
 Antagonist activity at human P2Y purinoceptor 2 expressed in human 1321N1 cells assessed as inhibition of UTP-induced increase in intracellular calcium concentration by spectrofluorimetry [AID644877, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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5
[SID136941525]
 Antagonist activity at human P2Y purinoceptor 4 expressed in human 1321N1 cells assessed as inhibition of UTP-induced increase in intracellular calcium concentration by spectrofluorimetry [AID644878, Type: Literature]P2Y purinoceptor 4 [gi:1709524]
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6
[SID136941525]
 Antagonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as inhibition of UDP-induced increase in intracellular calcium concentration by spectrofluorimetry [AID644879, Type: Literature]P2Y purinoceptor 6 [gi:2495019]
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7
[SID136941525]
 Antagonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as inhibition of 2-Sme-ADP-induced increase in intracellular calcium concentration by spectrofluorimetry [AID644876, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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